Cardiovascular & Haematological Disorders - Drug Targets - Volume 22, Issue 1, 2022

Background: Patients with hemophilia have a hypocoagulable state and less chances of thrombus formation. Therefore, they are expected to have a lower cardiovascular mortality than the general population. The lower cardiovascular mortality can be explained by less chances of thrombus formation due to hypocoagulability. Case Presentation: Here, we present a case of a 42-year-old male patient who presented with sever Read More

Background: Haematological manifestations in Hepatitis C virus (HCV) infection have been uncommon since the advent of direct-acting antiviral drugs (DAAs). However, primary HCV infection can cause significant haematological disease in the form of various autoimmune cytopenias. Case Presentation: We herein discuss a 68-years-old female with chronic HCV infection for the last 15 years (not on the treatment), who pres Read More

Background: Direct oral anticoagulants (DOACs) carry a lower potential risk of food/herb and drug interactions compared to oral vitamin K antagonists. However, as a new class of medications, drug interactions of DOACs have not been fully known. Case Presentation: We herein present the case of a 64-year old male with the complaint of acute onset epistaxis and bleeding gums following the concomitant use of rivaroxa Read More

Introduction: Parotid swellings are commonly encountered in ENT clinics, the cause of which could range from neural conditions, endocrine problems, vitamin deficiencies, and sialadenitis, which may even be a manifestation of an underlying systemic disease. Multiple myeloma represents a clonal proliferation of plasma cells and is a condition in which a parotid swelling might be present, although very uncommo Read More

Aims: The study aimed to assess the antihyperglycemic activity of Pelargonium graveolens. Background: Pelargonium graveolens (P. graveolens) (Geraniaceae) is a medicinal plant frequently used in traditional medicine in Morocco and Algeria as a remedy against a multitude of illnesses. Interestingly, it is also used in the Moroccan pharmacopeia for managing diabetes. Objective: The current study was carried out in order Read More

Aims: The aim of the study was to assess the antihypertensive activity of Hibiscus rosasinensis. Background: Hibiscus rosa-sinensis is used traditionally to treat hypertension. Objective: The goal of the study was to investigate the effect of the aqueous extract of Hibiscus rosa- sinensis flowers (AEHRS) on resting blood pressure in rats. Methods: In the present study, AEHRS was prepared, and its antihypertensive activity Read More

Background: Sacubitril/valsartan has revealed superior glycemic and blood pressure control compared with enalapril and irbesartan in patients with heart failure and type 2 diabetes and in individuals with chronic kidney disease. However, whether the effects of sacubitril/valsartan remain the same in those without heart failure is unknown. Methods: A multicenter randomized double-blinded trial will be carried out in five militar Read More

Aims: The study aimed to assess the antidiabetic effect of oakmoss. Background: Lichens species are dual organisms consisting of a mycobiont (Fungi) and a photoautotrophic partner (Algae). They are widely used in traditional medicine as a treatment for diabetes. Objective: This study was designed to assess the antihyperglycemic activity as well as the antihyperlipidemic capacity of oakmoss (Evernia prunastri (L.)) in norma Read More

Background: A better identification of the role of vitamin D in the thrombotic process of the acute coronary syndrome (ACS) will help increase the therapeutic options for this important clinical condition. There is little published evidence that 25-hydroxy vitamin D (25(OH)D) serum levels can associate with platelet function and risk of thrombosis. Methods: This prospective study was conducted on 200 patients with a diagnosis Read More

Aims: The present work aimed to assess the antihyperglycemic and antihyperlipidemic effects of Moricandia suffruticosa. Background: Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine. Objective: The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats. Methods: The effect of the aqueo Read More

Aims: The aim of the study was to assess the antihypertensive activity of Rumex vesicarius. Background: The genus Rumex (sorrel, Polygonaceae), containing approximately 200 species, is distributed worldwide (African, European, Asian, and American countries). It is widely used in traditional medicine as analgesic, diuretic, antispasmodic, and antihypertensive plant. Objectives: This study aimed to assess the possible antihyper Read More