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Volume 10, Issue 6
  • ISSN: 1566-5232
  • E-ISSN: 1875-5631

Abstract

Replication deficient adenovirus vectors are frequently used tools for the delivery of transgenes in vitro and in vivo. In addition, several therapeutic products based on adenovirus are under clinical development. This review outlines adenovirus vector production discussing different vector types, available production cell lines and state of the art of production process development and purification.

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/content/journals/cgt/10.2174/156652310793797694
2010-12-01
2024-12-23

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  • Article Type:     Research Article
Keyword(s): (HC-Ad) vector; 293; 911; A549 cells; Ac51 Ac139; Adenovirus; Adenovirus Reference Material Working Group (ARMWG); adenovirus vector; AEX (Fractogel DEAE; AEX (Toyopearl SuperQ; Aventis; Canji; cell concentration at infection (CCI); Cytodex-1; Cytodex-3 microcarriers; DNA-binding protein; DO; E1, E2, E3 and E4; E1/pIX genes; E1Ad; E2A; E2B (polymerase and preterminal protein; EM; FLPe; GFP-expressing AdV; GH329; hAd5; HDAd; helper-dependent E1-positive particles (HDEPs); hepatocytes; high performance liquid chromatography (HPLC); human embryonic kidney (HEK) cells; human embryonic retinoblasts; immobilized metal affinity chromatography (IMAC); Introgen; keratinocytes; Merck; Metabolic flux analysis; multiplicity of infection (MOI); N52.E6; NCL; oncolytic Ad vectors; pCO2; PER.C6; phosphoglycerate kinase (pgk) promoter; plaque-forming unit (PFU); plasmid expressing; Pluronic-F68; pol; polysorbate-80; process development; production; production cell lines; pTP; purification; RCA; Schering; SL0003; TCA cycle; time of harvest (TOH); tissue culture infectious dose 50 (TCID50); TOI; urothelial cells

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