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Volume 26, Issue 2
  • ISSN: 1389-2029
  • E-ISSN: 1875-5488

Abstract

Introduction

The gut microbiota plays a crucial role in maintaining human health, and probiotics have gained significant attention for their potential benefits. Among the diverse array of gut bacteria, and spp. have emerged as promising candidates for their putative probiotic properties.

Methods

In this study, we conducted a comprehensive comparative analysis of the genomes of and to decipher their probiotic potential. Utilizing a range of bioinformatics tools, we evaluated various genomic attributes, including functional gene content, metabolic pathways, antimicrobial peptide production, adhesion factors, and stress response elements. These findings revealed distinctive genomic signatures between the two genera. genomes exhibited a high prevalence of mucin-degrading enzymes, suggesting a specialized adaptation for mucin utilization in the gut environment.

Results

Additionally, the presence of specific pathways for short-chain fatty acid production highlighted its potential impact on host health. genomes, on the other hand, demonstrated a diverse repertoire of functional genes associated with probiotic attributes, including the production of antimicrobial peptides and adhesion factors, indicating potential for host-microbe interactions and immune modulation. Furthermore, this analysis unveiled the genetic basis of stress tolerance in both genera, revealing conserved mechanisms for surviving the dynamic conditions of the gut ecosystem.

Conclusion

This study also shed light on the distribution of antibiotic-resistance genes, allowing us to assess safety concerns associated with their potential use as probiotics. Overall, this comparative exploration provides valuable insights into the genomic foundation of and probiotic potential. These findings contribute to the understanding of their respective roles within the gut microbiota and offer a foundation for further experimental investigations. As probiotic applications continue to expand, this study advances our knowledge of the genetic underpinnings that govern their functionality and highlights promising avenues for future therapeutic interventions and personalized health strategies.

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Genomic Face-off: An In Silico Comparison of the Probiotic Potential of Lactobacillus spp. and Akkermansia muciniphila
Curr. Genomics 26, 129 (2025); https://doi.org/10.2174/0113892029317403240815044408
/content/journals/cg/10.2174/0113892029317403240815044408
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  • Article Type:     Research Article
Keyword(s): Akkermansia muciniphila; genome; In silico; Lactobacillus; probiotic; sequence

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