Effect of Geraniol against the Toxicity Induced by Paracetamol in the Third Instar Larvae of Transgenic Drosophila Melanogaster (hsp70-lac Z)Bg⁹

Background: Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants. It is commercially used as a fragrance compound in cosmetics and several products of a household. It possesses a number of biological properties. Objective: To study the effect of geraniol on the toxicity induced by paracetamol. Methods: In the present study, geraniol at the final concentration of 0.0005, 0.0025, 0.0050 and 0.0075 M was mixed in the diet along with the 0.0075 M of paracetamol and the third instar larvae of transgenic Drosophila melanogaster (hsp70-lac Z)Bg9 were allowed to feed on it for 24 hrs. Results: Larvae exposed to paracetamol along with the various doses of geraniol showed a dosedependent decrease in the activity of β-galactosidase, tissue damage, oxidative stress markers, DNA damage and apoptosis. The results suggest that geraniol is potent in reducing the toxicity induced by paracetamol in the third instar larvae of transgenic Drosophila. Conclusion: Hence, it is concluded that paracetamol showed toxic effects in the third instar larvae of transgenic Drosophila, and geraniol is potent in reducing the toxic effects induced by paracetamol.