Current Drug Targets - Volume 23, Issue 1, 2022

Meet the editorial board member page has been retracted at the request of editorial board member of the journal “Current Drug Targets”. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of Read More

Abstract: Parkinson’s disease (PD) is one of the most common types of neurological disorder prevailing worldwide and is rapidly increasing in the elderly population across the globe. The cause of PD is still unknown, but a number of genetic as well as environmental factors contributing to the pathogenesis of Parkinson’s disease have been identified. The hallmark of PD includes dopamine deficiency (neurotransmitter imbalanc Read More

Background: Molecular therapy with sorafenib remains the mainstay for advancedstage hepatocellular carcinoma. Notwithstanding, treatment efficacy is low, with few patients obtaining long-lasting benefits due to the high chemoresistance rate. Objective: To perform, for the first time, an overview of the literature concerning the role of adenosine triphosphate-binding cassette (ABC) transporters in sorafenib therapy for he Read More

Background: Chagas disease is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi and is transmitted to humans through the excreta of infected blood-sucking triatomine bugs. According to the World Health Organization, 6 to 7 million people are infected with T. cruzi worldwide, mainly in Latin America, with more than 10000 deaths annually. Aim of the Study: The present study ai Read More

Abstract: Tumors are made up of different types of cancer cells that contribute to tumor heterogeneity. Among these cells, cancer stem cells (CSCs) have a significant role in the onset of cancer and development. Like other stem cells, CSCs are characterized by the capacity for differentiation and self-renewal. A specific population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into mesoderm-specific ce Read More

Background: Antiviral resistance and inefficiency of available antiviral drugs to effectively treat viral infections have prompted many researchers worldwide to explore medicinal plants and their isolated compounds as alternative antivirals. The rich flora from the Mascarene Islands has also been thoroughly studied for their wide therapeutic activities, including their antiviral properties. Objective: The aim of this review is to hi Read More

Abstract: Wound healing is a complex and never-ending process that involves numerous mediators, enzymatic cascades that are directly or indirectly involved in the mechanism. So, it becomes necessary to closely examine critical factors such as gaseous exchange, a moist environment, anti- microbial activity, and exudation liquids' absorption while designing wound dressings. There is a heap of wound dressings available Read More

Abstract: The Angiotensin II type 2 Receptor (AT2R) is one of the critical components of the renin- angiotensin system (RAS), which performs diverse functions like inhibiting cell differentiation, cell proliferation, vasodilatation, reduces oxidative stress and inflammation. AT2R is relatively less studied in comparison to other components of RAS despite its uniqueness (sex-linked) and diverse functions. The AT2R is differentially ex Read More