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Volume 25, Issue 12
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

Corticosteroids are widely utilized for their anti-inflammatory and immunosuppressive properties but often lead to ocular complications, including ocular hypertension. If untreated, ocular hypertension can progress to optic nerve atrophy and eventually result in steroid-induced glaucoma, which poses a risk of irreversible visual damage. Approximately 40% of individuals experience increased intraocular pressure after steroid use, and around 6% develop glaucoma. Although steroid-induced glaucoma is usually temporary and reversible if the treatment duration is under a year, prolonged exposure can cause permanent vision impairment. The pathogenesis of steroid-induced glaucoma is suggested to arise from increased outflow resistance of aqueous humor, primarily due to decreased expression of matrix metalloproteinases. This deficiency promotes the deposition of extracellular matrix and the dysfunction of trabecular meshwork cells. Additionally, modifications in the actin cytoskeleton increase the stiffness and alter the morphology of trabecular meshwork, further impeding aqueous humor outflow. Molecular changes, such as elevated expression of the MYOC gene, have also been implicated in restricting aqueous outflow. Various animal models, including rats, mice, primates, rabbits, cattle, sheep, cats, and dogs, have been developed to study steroid-induced glaucoma. These models exhibit pathological, pathophysiological, and molecular similarities to human disease, making them valuable for research. This review aims to summarize common animal models of steroid-induced ocular hypertension, discussing their advantages and limitations. The goal is to help researchers select appropriate models for future studies, thereby advancing the understanding of disease mechanisms and developing preventive strategies.

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/content/journals/cdt/10.2174/0113894501333936240801053620
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In Vivo Models of Steroid-Induced Intraocular Hypertension
Curr Drug Targets 25, 775 (2024); https://doi.org/10.2174/0113894501333936240801053620
/content/journals/cdt/10.2174/0113894501333936240801053620
/content/journals/cdt/10.2174/0113894501333936240801053620
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  • Article Type:     Review Article
Keyword(s): Corticosteroids; in vivo model, ocular hypertension, steroids; intraocular hypertension; intraocular pressure

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