- Home
- A-Z Publications
- Current Drug Research Reviews
- Fast Track Listing
Current Drug Research Reviews - Online First
Description text for Online First listing goes here...
-
-
Harnessing Hyaluronic Acid: A Promising Avenue for Dry Eye Relief
Available online: 04 December 2024More Less
-
-
-
A Narrative Overview of Retinoid X Receptor Inhibitors in Chronic Disease Management
Authors: Calvin R. Wei, Muhammad Osama and Saleha TahirAvailable online: 02 December 2024More LessThe Retinoid X Receptor (RXR) is a member of the nuclear receptor superfamily and regulates gene transcription as well as diverse cellular processes like metabolism, inflammation, and cell differentiation. As an attractive therapeutic target, RXR inhibitors have garnered attention for their potential in alleviating chronic diseases. RXR inhibitors have the potential to modulate inflammation and immune responses and manage diseases like rheumatoid arthritis, inflammatory diseases, metabolic disorders such as diabetes and dyslipidemia, cancer progression, solid tumors, and hematologic malignancies. Understanding the molecular mechanisms behind their therapeutic effects is crucial for optimizing their use in different disease contexts. While RXR inhibitors hold promise, some challenges and questions necessitate further research. Future directions include refining the understanding of specific pathways affected by RXR inhibition and addressing potential side effects along with tailoring treatment approaches based on individual patient characteristics, as this would improve outcomes. Exploring the potential synergies of RXR inhibitors with other therapeutic agents could enhance their efficacy and broaden their applicability.
-
-
-
Platelet-rich Plasma for the Treatment of Neuropathic Pain: A Systematic Review
Available online: 14 October 2024More LessBackgroundNeuropathic pain (NP) presents a significant actual public health challenge. Traditional treatments primarily involve medications, but these approaches frequently yield unsatisfactory results, highlighting the need to explore alternative therapies, such as platelet-rich plasma (PRP), an autologous plasma derivative enriched with platelets.
ObjectiveThis article aims to systematically review the literature and provide an updated assessment of the efficacy and safety of PRP treatment for NP.
MethodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched databases, including Web of Science, Embase, PubMed, Scopus, and Cochrane Library. We assessed bias risk using the Cochrane Risk of Bias 2 tool (RoB2).
ResultsAmong 1230 studies identified, 12 randomized trials meeting eligibility criteria were included. Due to substantial heterogeneity, pairwise meta-analysis and intervention ranking were found to be unfeasible. Most trials suggest PRP is effective in relieving NP, with no reported serious complications or significant PRP-related adverse effects. However, these findings were compromised by methodological heterogeneity and study inconsistency.
ConclusionPRP has shown to be promising as a safe therapeutic option for managing NP. Future studies should prioritize improved rigor and reproducibility for more stringent conclusions.
-