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Volume 21, Issue 3
  • ISSN: 1573-3998
  • E-ISSN: 1875-6417

Abstract

Background

Diabetes mellitus remains a global health challenge, demanding innovative therapeutic strategies. Herbal remedies have garnered attention for their potential in diabetes management, and recent advancements in nanotechnology have enabled the development of herbal nanoformulations with enhanced efficacy and bioavailability.

Objective

This review aimed to comprehensively analyze the mechanisms, formulations, and clinical impact of herbal nanoformulations in managing diabetes mellitus.

Methods

A systematic literature search was conducted to identify relevant studies exploring the mechanisms of action, various formulations, and clinical outcomes of herbal nanoformulations in diabetes management.

Results

Herbal nanoformulations exert their anti-diabetic effects through multiple mechanisms, including enhanced bioavailability, improved tissue targeting, and potentiation of insulin signaling pathways. Various herbal ingredients, such as bitter melon, fenugreek, and Gymnema sylvestre, have been encapsulated into nanocarriers, like liposomes, polymeric nanoparticles, and solid lipid nanoparticles, to enhance their therapeutic potential. Clinical studies have demonstrated promising results, showing improvements in glycemic control, lipid profile, and antioxidant status with minimal adverse effects.

Conclusion

Herbal nanoformulations represent a promising avenue for the management of diabetes mellitus, offering improved therapeutic outcomes compared to conventional herbal preparations. Further research is warranted to optimize formulation strategies, elucidate long-term safety profiles, and explore the potential synergistic effects of herbal nanoformulations in combination therapies for diabetes management.

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2024-11-22

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/content/journals/cdr/10.2174/0115733998288592240308073925
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Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact
Curr. Diabetes Rev. 21, E180324228072 (2025); https://doi.org/10.2174/0115733998288592240308073925
/content/journals/cdr/10.2174/0115733998288592240308073925
/content/journals/cdr/10.2174/0115733998288592240308073925
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  • Article Type:     Review Article
Keyword(s): clinical efficacy; diabetes mellitus; Herbal nanoformulations; nanoparticles; nanosuspension; nanosystem

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