Current Drug Discovery Technologies - Volume 5, Issue 2, 2008

One of the prerequisite processes in living cells is the ability to maintain the simultaneous, hierarchical and selective transmembrane transport of ions, molecules and waste products employing highly evolved proteins, self-organized in the form of specific and sophisticated ion channels or biomolecule nanocarriers. The examples of synthetic approach to the preparation of such supramolecular transporters include natural p Read More

Anion transport across phospholipid membrane is a typical supramolecular function involving dynamic recognition of the substrate during the whole translocation process. Supramolecular chemists, taking inspiration by the natural anion transporters, have designed artificial systems able to mimic, at the functional level, several features of the natural ion channels. The scope of this research is twofold: on one hand to get insi Read More

The present minireview summarizes some potential applications of calix[n]arenes family in binding and transport through liquid membranes of various biological compounds. In this respect, some specific aspects of their applications as carriers through liquid membrane are discussed in view of their potential for development of new drug formulation. The place of calix[n]arenes in the interesting and challenging field of transm Read More

The permanent world-wide increase in therapeutic administration of racemic profens as easy available non-prescribed analgesic drugs and a common first-choice anti-inflammatory agents was recently linked with renewed interest in their beneficial use, also as enantiopure formulations, to treat and/or prevent a variety of human malignancies including its four major types as colorectal, breast, lung, and prostate cancer. This Read More

The paper gives a short review of the most important research results published recently in the field of the applications of supramolecular nanocarriers in modern pharmaceutical and analytical chemistry. The main attention has been paid to the fast developing technology of chemical sensors, ion-selective electrodes and separation methods, in particular to newly designed packing in highperformance liquid chromatogr Read More

This study reports the use of para-sulphonato calix[8]arene to produce stable complexes with improved bioavailability for nifedipine, a calcium-channel blocker that is practically insoluble in water. Thermal analysis and electrospray ionisation mass spectroscopy confirmed that nifedipine formed complexes with the calixarenes in a size dependent way. The most stable, soluble complexes was formed with para-sulphonato c Read More

The aim of this work is to analyze the effect of cyclodextrin (CD) complexation on the solubilization and stabilization of sodium dicloxacillin in acid aqueous solutions. The effect of four cyclodextrins α-, β-,γ- and hydroxypropyl-β-CD was studied. Phase solubility diagrams obtained are AL or BS type, depending on the cyclodextrin used and on the pH of the solution. The highest stability constants of the inclusion complexes are ob Read More

The main purpose of this work was to accomplish a comparative study about cyclodextrins complexation equilibria with three benzimidazolic antihelmintics: albendazole (Alb), mebendazole (Meb) and thiabendazole (Thiab).The complexation process with four different cyclodextrins (α-, β-, γ-, and HP-β-CDs) was investigated under various temperatures and different reaction media (aqueous solution buffered at pH 7.5, dime Read More

The complexation of carboxylic acid Monensin A (MonH, 1a) with CoCl2.6H2O and MnCl2.4H2O leads to the formation of mononuclear complexes [Co(Mon)2(H2O)2], 2a and [Mn(Mon)2(H2O)2], 2b, respectively. The unique crystal structures of 2a and 2b were determined by X-ray crystallography. The complexes crystallize in the monoclinic space group P21 with an octahedrally coordinated transition metal center fo Read More

Complex molecular ensembles are frequently considered an element of new pharmacological formulations. This is especially evident in the therapies based on genetic information. In order to obtain an effective drug, it is necessary to associate a nucleic acid molecule with the components to ensure the desired aggregate structure and properties. To evaluate the progress of the supromolecular aggregate form Read More

The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interaction Read More

β-Cyclodextrin (β-CD) forms a series of supramolecular complexes with aromatic or aliphatic guest molecules such as benzaldehyde, butyl acrylate, etc. Remarkable blue shifts (λmax) of the UV-vis absorption peaks of the guest molecules are observed after the formation of inclusion complexes. The congestion lines appearing in the guest molecules are reduced in a remarkable extent accordingly. The mechanisms of the blue shif Read More

Retention profiles in series of the neutral and highly hydrophobic 1,3,4-oxadiazoles containing chlorophenylurea and halogenobenzamide moiety and indicating analgesic activity were determined in the isocratic standard- and narrow-bore HPLC systems employing, respectively, various octadecylsilica and different calixarene bonded stationary phases. When acetonitrile - 2.65 mM phosphoric acid (55 : 45, %, v/v), pH* 3.2 Read More