Current Drug Discovery Technologies - Volume 18, Issue 6, 2021

Background: Obesity is a common health concern among all populations and age groups worldwide and is a risk factor that leads to a significant increase in mortality and cardiovascular diseases, type 2 diabetes, metabolic syndrome, stroke, and cancer. Disappointing results and weight regain after stopping lifestyle modification or drug therapy indicate the need for other methods of treatment to achieve better and longer effec Read More

Micro-RNAs (miRNA) are short non-coding sequences involved in the biological regulatory process. The miRNAs show a unique expression in diseases, resulting in pathogenesis. Identifying the novel compounds is interesting during this process. The miRNA is a biomarker that helps to detect cancer at an early stage through pathogenesis. Azobenzene and pyrazole are novel compounds, having a cytotoxic effect on can Read More

Medicinal plants and dietary supplements may provide an effective and safe treatment for pain relief. Green tea is one of the most common beverages with many several pharmacological activities. The results of various studies have indicated that green tea possesses antinociceptive effects. Many of the protective effects of green tea in terms of pain relief are attributed to its antioxidant and anti-inflammatory properti Read More

A novel coronavirus termed nCoV-2019 that caused an epidemic of acute respiratory syndrome in humans was first detected in Wuhan, China, in December 2019. nCoV-2019 resulted in thousands of cases of lethal disease all around the world. Unfortunately, there is no specific treatment yet, so a better understanding of the pathobiology of the disease can be helpful. The renin-angiotensin system and its products have several Read More

Background: Sexual health plays an important role in women’s health and quality of life. Sexual health management is a prerequisite for physical and psychological health of women. Sexual desire, arousal, and orgasm are three factors of female sexual response. Objectives: This study aimed at the evaluation of the studies focusing on herbal medicine on women's sexual function and the assessment of its effectiveness. Metho Read More

Aims and Objectives: The biological dataset was retrieved from two series of α-glucosidase inhibitors synthesized by Rahim et al. and Taha et al. and consisted of a total of 46 (forty-six) α- glucosidase inhibitors. Methods: The α-glucosidase inhibitory IC50 values (μM; performed against α-glucosidase from Saccharomyces cerevisiae) were converted into negative logarithmic units (pIC50). The CoMFA and CoMSIA models we Read More

Objectives: The present study was conducted to evaluate the antimicrobial effects of the recombinant chimer present in the lactoferrampin-lactoferricin [LFA-LFC] derived from the camel milk on some oral bacteria responsible for dental caries and endodontic failures. Methods and Material: The antimicrobial activity was assessed on the Streptococcus mutans [ATCC 35668], Streptococcus salivarius [ATCC 9222], Stre Read More

Background: The anticancer properties of natural products calactin, calotropin and calotoxin are well established. However, the mechanisms of their action are unclear and the molecular targets pertinent to them are not detailed. In this study, potential anti-cancer targets of these compounds have been identified using reverse screening approaches that may provide valuable insights into anticancer drug developm Read More

Background & Objective: A facile and efficient method for the synthesis of novel derivatives of FQ citrate conjugates with 1,2,4-triazoles and 1,3,4-oxadiazole scaffolds 8-11 using conventional, as well as microwave irradiation methods, was reported. Based on these original building blocks, the new derivatives of 3, 7-disubstituted fluoroquinolones bearing the oxadiazolyl-triazole groups were obtained. These invaluable derivative Read More

Background: Anti-apoptotic protein BCL-XL plays a vital role in tumorigenesis and cancer chemotherapy resistance, resulting in a good target for cancer treatment. Understanding the function of BCL-XL has driven the progression of a new class of cancer drugs that can mimic its natural inhibitors, BH3-only proteins, to trigger apoptosis. This mimicking is initiated through acetogenins due to their excellent biological proper Read More