Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Drug Discovery Technologies
  4. Volume 22, Issue 1
  5. Article
Volume 22, Issue 1
  • ISSN: 1570-1638
  • E-ISSN: 1875-6220

Abstract

, commonly known as Elephant Apple, is a significant medicinal plant found in Assam, North-East India. This evergreen shrub or small to medium-sized tree possesses not only tasty components but also a plethora of beneficial therapeutic characteristics. This review article aims to explore the potential use of in the treatment of diabetes and other diseases, as well as discuss various patents associated with this plant. The study focuses on identifying different formulations derived from various parts of . These formulations encompass a range of dosage forms, including mucoadhesive buccal dosage forms, buccal patches, microbeads, emulgel, and mucoadhesive nasal gel. Each of these dosage forms offers unique advantages and applications. Mucoadhesive buccal dosage forms are designed to adhere to the oral mucosa, allowing for controlled drug release and enhanced absorption. Buccal patches provide a convenient and localized delivery system for specific therapeutic agents. Microbeads offer a versatile approach for encapsulating drugs and facilitating their controlled release. Emulgels combine the benefits of both emulsions and gels, providing improved drug delivery and stability. Mucoadhesive nasal gels offer a non-invasive route for drug administration, allowing for rapid absorption through the nasal mucosa. By exploring these different formulations, researchers aim to harness the therapeutic potential of in a variety of diseases, including diabetes. The study also highlights the importance of patents associated with , indicating the growing interest in its medicinal properties and potential commercial applications. holds promise as a valuable medicinal plant, with its diverse therapeutic characteristics and tasty components. The study discussed various formulations derived from different parts of the plant, showcasing their potential applications in the treatment of diseases. Further research and development in this field may lead to the discovery of novel treatments and contribute to the advancement of pharmaceutical science.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cddt/10.2174/0115701638292980240407135246
2025-01-01
2024-11-01

  • From This Site

    /content/journals/cddt/10.2174/0115701638292980240407135246
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. BaruaC.C. YasminN. BuragohainL. A review update on Dillenia indica, its morphology, phytochemistry and pharmacological activity with reference to its anticancer activity.MOJ Bioequivalence & Bioavailability.20185524425410.15406/mojbb.2018.05.0011
     [Google Scholar]
  2. RaiH. SajwanS.U.A. An overview of Dillenia indica and their properties.Pharma Innovation Journal2020964144
     [Google Scholar]
  3. MetiaP.K. BandyopadhyayA.K. In vitro and in vivo evaluation of a novel mucoadhesive buccal oxytocin tablet prepared with Dillenia indica fruit mucilage.Pharmazie200863427027418468385
     [Google Scholar]
  4. DeD. ChowdhuryP. PandaS.K. GhoshU. Leaf Extract and Active Fractions of Dillenia pentagyna Roxb. Reduce In Vitro Human Cancer Cell Migration Via NF-κB Pathway.Integr. Cancer Ther.20222110.1177/1534735422112883236419372
     [Google Scholar]
  5. LimaC.C. LemosR.P.L. ConservaL.M. Dilleniaceae family: an overview of its ethnomedicinal uses, biological and phytochemical profile.J. Pharmacogn. Phytochem.20143181204
     [Google Scholar]
  6. NayakS. BhatM.P. UdayashankarA.C. LakshmeeshaT.R. GeethaN. JogaiahS. Biosynthesis and characterization of Dillenia indica -mediated silver nanoparticles and their biological activity.Appl. Organomet. Chem.2020344e556710.1002/aoc.5567
     [Google Scholar]
  7. HasnainM.S. GuruP.R. RishishwarP. AliS. AnsariM.T. NayakA.K. Atenolol-releasing buccal patches made of Dillenia indica L. fruit gum: preparation and ex vivo evaluations.SN Applied Sciences2020215710.1007/s42452‑019‑1756‑x
     [Google Scholar]
  8. ParvinM.N. RahmanM.S. IslamM.S. RashidM.A. Chemical and biological investigations of Dillenia indica Linn. |||.Bangladesh J. Pharmacol.200942122125
     [Google Scholar]
  9. GandhiD. MehtaP. Dillenia indica Linn. and Dillenia pentagyna Roxb.: Pharmacognostic, phytochemical and therapeutic aspects.J. Appl. Pharm. Sci.2013311134142
     [Google Scholar]
  10. AjalaT. SilvaB. The design of ibuprofen-loaded microbeads using polymers obtained from Xanthosoma sagittifolium and Dillenia indica.Polim. Med.2020501213110.17219/pim/12201532975053
     [Google Scholar]
  11. AjalaT.O. EragaS.O. Akin-AjaniO.D. The gelling properties of Dillenia indica mucilage in benzyl benzoate emulgel formulations.Brazil. J. Pharmaceut. Sci.20225810.1590/s2175‑97902022e20263
     [Google Scholar]
  12. SaikiaD. KesavanR. Stephen InbarajB. DikkalaP.K. NayakP.K. SridharK. Bioactive compounds and health-promoting properties of elephant apple (dillenia indica l.): a comprehensive review.Foods20231216299310.3390/foods1216299337627992
     [Google Scholar]
  13. OuB. HuangD. Hampsch-WoodillM. FlanaganJ.A. DeemerE.K. Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative study.J. Agric. Food Chem.200250113122312810.1021/jf011660612009973
     [Google Scholar]
  14. SaikumarA. NickhilC. BadwaikL.S. Physicochemical characterization of elephant apple (Dillenia indica L.) fruit and its mass and volume modeling using computer vision.Sci. Hortic.202331411194710.1016/j.scienta.2023.111947
     [Google Scholar]
  15. KrishnanK.R. RayaguruK. NayakP.K. Ultra-sonicated vacuum drying’s effect on antioxidant activity, TPC, TFC and color of elephant apple slices.Food Biosci.20203610062910.1016/j.fbio.2020.100629
     [Google Scholar]
  16. ShiojimaK. AraiY. MasudaK. TakaseY. AgetaT. AgetaH. Mass spectra of pentacyclic triterpenoids.Chem. Pharm. Bull.19924071683169010.1248/cpb.40.1683
     [Google Scholar]
  17. SaikiaD. NayakP.K. BoruhaB. KrishnanK.R. DashU. BalL.M. Effect of pre-drying and microwave-assisted vacuum frying on elephant apple.J. Sci. Ind. Res.20228109989994
     [Google Scholar]
  18. BorahU. BaruahR. KalitaS. DuttaF. BorahA. Das PurkayasthaM. Core-shell structured α-tocopherol acetate encapsulation using elephant apple mucilage-alginate matrix: In vitro digestion and thermal degradation kinetics.Food Biosci.20225010218910.1016/j.fbio.2022.102189
     [Google Scholar]
  19. KhanM.A. AhamadT. SaquibM. HussainM.K. KhanM.F. Unmodified household coffee maker assisted extraction and purification of anticancer agents from Dillenia indica fruits.Nat. Prod. Res.20193569848731134812
     [Google Scholar]
  20. KhanS. BhowmikA. RhamanS.B. GanS.H. RokeyaB. Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects.bioRxiv201980481510.1101/804815
     [Google Scholar]
  21. Nutritional Contents and Medicinal Potential of Dillenia indica: A Review.Nairobi J. Food Sci. Technol.202011Available from: https://www.royalliteglobal.com/njfst/article/view/307
    [Google Scholar]
  22. KumarS. KumarV. PrakashO. Enzymes inhibition and antidiabetic effect of isolated constituents from Dillenia indica. BioMed Res. Int.201320131710.1155/2013/38206324307994
     [Google Scholar]
  23. SuleR.O. CondonL. GomesA.V. A common feature of pesticides: oxidative stress—the role of oxidative stress in pesticide-induced toxicity.Oxid. Med. Cell. Longev.2022202213110.1155/2022/556375935096268
     [Google Scholar]
  24. SinghK.D. MoboladeA.J. BharaliR. SahooD. RajashekarY. Main plant volatiles as stored grain pest management approach: A review.J. Agricult. Food Res.2021410012710.1016/j.jafr.2021.100127
     [Google Scholar]
  25. MarklundS. MarklundG. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.Eur. J. Biochem.197447346947410.1111/j.1432‑1033.1974.tb03714.x4215654
     [Google Scholar]
  26. NandipatiS. LitvanI. Environmental exposures and Parkinson’s disease.Int. J. Environ. Res. Public Health201613988110.3390/ijerph1309088127598189
     [Google Scholar]
  27. SinghK.D. JenaS. PatraB. DeviT.B. ChawlaS. BharaliR. ParidaA. MukherjeeP.K. RajashekarY. Safety evaluation of enriched fraction from leaves of Dillenia indica L. in BALB/c mice.Toxicol. Rep.202291142114910.1016/j.toxrep.2022.05.00736518394
     [Google Scholar]
  28. LowryO. RosebroughN. FarrA.L. RandallR. Protein measurement with the Folin phenol reagent.J. Biol. Chem.1951193126527510.1016/S0021‑9258(19)52451‑614907713
     [Google Scholar]
  29. SabarwalA. KumarK. SinghR.P. Hazardous effects of chemical pesticides on human health–Cancer and other associated disorders.Environ. Toxicol. Pharmacol.20186310311410.1016/j.etap.2018.08.01830199797
     [Google Scholar]
  30. SinghK.D. KoijamA.S. BharaliR. RajashekarY. Insecticidal and biochemical effects of Dillenia indica L. leaves against three major stored grain insect pests.Front. Plant Sci.202314113594610.3389/fpls.2023.113594636890902
     [Google Scholar]
  31. AnsareyS.H. Inflammation and JNK’s role in niacin-gpr109a diminished flushed effect in microglial and neuronal cells with relevance to schizophrenia.Front. Psychiatry20211277114410.3389/fpsyt.2021.77114434916973
     [Google Scholar]
  32. KumarS. KumarV. PrakashO. Microscopic evaluation and physiochemical analysis of Dillenia indica leaf.Asian Pac. J. Trop. Biomed.20111533734010.1016/S2221‑1691(11)60076‑223569789
     [Google Scholar]
  33. HasnainM.S. RishishwarP. AliS. AlkahtaniS. TabishM. MilivojevicM. AnsariM.T. NayakA.K. Formulation and ex vivo skin permeation of lidocaine HCl topical gels using dillenia (Dillenia indica L.) fruit gum.Rev. Mex. Ing. Quim.20201931465147610.24275/rmiq/Mat1185
     [Google Scholar]
  34. KambojP. TalukdarN.C. BanerjeeS.K. Therapeutic benefit of Dillenia indica in diabetes and its associated complications.J. Diabetes Res.201920191710.1155/2019/463249131871947
     [Google Scholar]
  35. SahuB.P. SharmaH.K. DasM.K. Development and evaluation of a mucoadhesive nasal gel of felodipine prepared with mucoadhesive substance of Dillenia indica L.Asian J Pharm Sci.20115175187
     [Google Scholar]
  36. ApuA.S. MuhitM.A. TareqS.M. PathanA.H. JamaluddinA.T.M. AhmedM. Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of dillenia indica linn.J. Young Pharm.201021505310.4103/0975‑1483.6221321331191
     [Google Scholar]
  37. TalukdarA. TalukdarN. DekaS. SahariahB.J. Dillenia indica (OUTENGA) as anti-diabetic herb found in Assam: A review.Int. J. Pharm. Sci. Res.2012382482
     [Google Scholar]
  38. FuC. YangD. PehW.Y.E. LaiS. FengX. YangH. Structure and antioxidant activities of proanthocyanidins from elephant apple (Dillenia indica Linn.).J. Food Sci.20158010C2191C219910.1111/1750‑3841.1300526416622
     [Google Scholar]
  39. HandaS.S. An overview of extraction techniques for medicinal and aromatic plants. HandaS.S. KhanujaS.P.S. LongoG. RakeshD.D. Extraction technologies for medicinal and aromatic plants.Trieste, ItalyInternational Centre for Science and High technology20082152
     [Google Scholar]
  40. Yunnan Agricultural University “Extraction technology of flavonoid pigments from Dillenia indica fruits.CN 107969610 A2018
  41. BruzeM. IsakssonM. Dooms-GoossensA. The influence of patch tests with clobetasol propionate on adjacent patch test reactions.Contact Dermat.199532316717010.1111/j.1600‑0536.1995.tb00809.x7774190
     [Google Scholar]
  42. GeethaR. AshokkumarT. TamilselvanS. GovindarajuK. SadiqM. SingaraveluG. Green synthesis of gold nanoparticles and their anticancer activity.Cancer Nanotechnol.201344-5919810.1007/s12645‑013‑0040‑926069504
     [Google Scholar]
  43. ArmaniaN. YazanL.S. MusaS.N. IsmailI.S. FooJ.B. ChanK.W. NoreenH. HisyamA.H. ZulfahmiS. IsmailM. Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest.J. Ethnopharmacol.2013146252553510.1016/j.jep.2013.01.01723353897
     [Google Scholar]
  44. SudipM. SushmaV. SujataP. Ayan KumarB. Manika PalB. BojjaS. Chitta RanjanP. Green chemistry approach for the synthesis and stabilization of biocompatible gold nanoparticles and their potential applications in cancer therapyNanotechnology2012234545510310.1088/0957‑4484/23/45/45510323064012
     [Google Scholar]
  45. BadrulA.M. SaifurR.M. HasanM. Maruf KhanM. KamrunN. SheemaS. Antinociceptive and Antioxidant Activities of the Dillenia indica Bark.Int. J. Pharmacol.201284243251
     [Google Scholar]
  46. YoanitaR. Formula for tea made from Simpur leaves (Dillenia indica) for anti-cholesterol.SID201805246,2018
  47. DeepaN. JenaB.S. Antioxidant fraction from bark of Dillenia indica.Int. J. Food Prop.20111451152115910.1080/10942911003592779
     [Google Scholar]
  48. OtaM. Composition containing Dillenia indica.JP19971473281998
  49. ChawiratA. Ingredient formula for capsules that contain Shan Chang, Shan Shan, Matad as ingredients.JP15010027032016
  50. A process for the preparation of antioxidants from dillenia indicaWO2004050109A12004
  51. BirenK. A herbal composition for prevention and treatment of retention of placenta and process thereof.WO2012131716A32023
  52. MohamedS. HasanZ. Extraction and characterisation of pectin from various tropical agrowastes.ASEAN Food J.19951024350
     [Google Scholar]
  53. KrishnanM. RanganathanK. MaadhuP. ThangaveluP. KundanS. ArjunanN. Leaf extract of Dillenia indica as a source of selenium nanoparticles with larvicidal and antimicrobial potential toward vector mosquitoes and pathogenic microbes.Coatings202010762610.3390/coatings10070626
     [Google Scholar]
  54. JyotiG.B. A process for the preparation of herbal health drink.EP3509430B12009
  55. KrugerM.J. DaviesN. MyburghK.H. LecourS. Proanthocyanidins, anthocyanins and cardiovascular diseases.Food Res. Int.201459415210.1016/j.foodres.2014.01.046
     [Google Scholar]
  56. PorterL.J. HrstichL.N. ChanB.G. The conversion of procyanidins and prodelphinidins to cyanidin and delphinidin.Phytochemistry198525122323010.1016/S0031‑9422(00)94533‑3
     [Google Scholar]
  57. LiangHeng A natural food antioxidant.US20090048332A12015
  58. KaurN. KishoreL. SinghR. Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy.J. Ethnopharmacol.2017206193010.1016/j.jep.2017.05.01828506898
     [Google Scholar]
  59. AmeamsriU. ChaveerachA. SudmoonR. TaneeT. PeigneurS. TytgatJ. Oleamide in Ipomoea and Dillenia species and inflammatory activity investigated through ion channel inhibition.Curr. Pharm. Biotechnol.202122225426110.2174/138920102166620060718525032515307
     [Google Scholar]
  60. SongB.R. AlamM.B. LeeS.H. Terpenoid-rich extract of Dillenia indica L. bark displays antidiabetic action in insulin-resistant C2C12 cells and STZ-induced diabetic mice by attenuation of oxidative stress.Antioxidants2022117122710.3390/antiox1107122735883721
     [Google Scholar]
  61. Ronda VioletaS. Process of producing fruit wine. Intellectual property office of philippinesCN1288946A2013
  62. TeneK. KumarK. PemmarajuD.B. KumarJ. ShantanuP.A. GogoiR. NaiduV.G.M. Ameliorative effect of Dillenia indica fruits against doxorubicin-induced cardiomyocyte toxicity.Advances in Traditional Medicine202121480581410.1007/s13596‑020‑00510‑1
     [Google Scholar]
  63. NishimuraKoichiro Cyclic amp (camp) production inhibitor.2003157577, Japan Patent Office2003
  64. AlamM.B. ChowdhuryN.S. MazumderM.E.H. HaqueM.E. Antimicrobial and toxicity study of different fractions of Dillenia indica Linn. bark extract.Int. J. Pharm. Sci. Res.201124860
     [Google Scholar]
  65. KaurN. KishoreL. SinghR. Antidiabetic effect of new chromane isolated from Dillenia indica L. leaves in streptozotocin induced diabetic rats.J. Funct. Foods20162254755510.1016/j.jff.2016.02.016
     [Google Scholar]
  66. ShangA. LiuH.Y. LuoM. XiaY. YangX. LiH.Y. WuD.T. SunQ. GengF. GanR.Y. Sweet tea ( Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits.Crit. Rev. Food Sci. Nutr.202262491793410.1080/10408398.2020.183036333030031
     [Google Scholar]
  67. KumarS. KumarV. PrakashO. Antidiabetic and hypolipidemic activities of Dillenia indica extract in diabetic rats.J. Chin. Integr. Med.20119557057410.3736/jcim2011051721565146
     [Google Scholar]
  68. Jong-AnurakkunN. BhandariM.R. KawabataJ. α-Glucosidase inhibitors from Devil tree (Alstonia scholaris).Food Chem.200710341319132310.1016/j.foodchem.2006.10.043
     [Google Scholar]
  69. Espitia-HernándezP. Chávez GonzálezM.L. Ascacio-ValdésJ.A. Dávila-MedinaD. Flores-NavedaA. SilvaT. Ruelas ChacónX. SepúlvedaL. Sorghum ( Sorghum bicolor L.) as a potential source of bioactive substances and their biological properties.Crit. Rev. Food Sci. Nutr.20226282269228010.1080/10408398.2020.185238933280412
     [Google Scholar]
  70. PotteratO. Antioxidants and free radical scavengers of natural origin.Curr. Org. Chem.19971441544010.2174/1385272801666220126162734
     [Google Scholar]
  71. JaiswalS. MansaN. PrasadM.S.P. JenaB.S. NegiP.S. Antibacterial and antimutagenic activities of Dillenia indica extracts.Food Biosci.20145475310.1016/j.fbio.2013.11.005
     [Google Scholar]
  72. Jean BaptisteS. LeT.H.Y. LeT.K.V. VuD.N. NguyenD.D. Anti-cancer immune-modulatory activities of panax genus extracts and bioactive compounds.Food Rev. Int.20223871461148410.1080/87559129.2020.1817065
     [Google Scholar]
  73. AkterR. UddinS.J. GriceI.D. TiralongoE. Cytotoxic activity screening of Bangladeshi medicinal plant extracts.J. Nat. Med.201468124625210.1007/s11418‑013‑0789‑523846168
     [Google Scholar]
  74. YeshwanteS.B. JuvekarA.R. NagmotiD.M. WankhedeS.S. ShahA.S. PimprikarR.B. SaindaneD.S. Anti-inflammatory activity of methanolic extracts of Dillenia indica L. leaves.J. Young Pharm.2009116310.4103/0975‑1483.51885
     [Google Scholar]
  75. ParasuramanS. Anand DavidA.V. ArulmoliR. Overviews of biological importance of quercetin: A bioactive flavonoid.Pharmacogn. Rev.20161020848910.4103/0973‑7847.19404428082789
     [Google Scholar]
  76. YeshwanteS.B. JuvekarA.R. PimprikarR.B. KakadeR.T. TabrejM. KaleM.K. FirkeS.D. Anti-diarrheal activity of methanolic and aqueous extracts of dillenia indica L.Res. J. Pharmacol. Pharmacodyn.20091140142
     [Google Scholar]
  77. RahmanM.S. Shams-Ud-DohaK.M. RahmanR. Antidiarroheal activity of the leaf and fruit extracts of Dillenia indica. Int. J. Biosci.201113946
     [Google Scholar]
  78. ShobaF.G. ThomasM. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea.J. Ethnopharmacol.2001761737610.1016/S0378‑8741(00)00379‑211378284
     [Google Scholar]
  79. BoseU. GunasekaraK. BalaV. RahmanA.A. Evaluation of phytochemical and pharmacological properties of dillenia indica linn. leaves.J. Pharmacol. Toxicol.20105522222810.3923/jpt.2010.222.228
     [Google Scholar]
  80. YeshwanteS.B. JuvekarA.R. NagmotiD.M. WankhedeS. In vivo analgesic activity of methanolic extract of Dillenia indica (L)leaves.Pharmacol.2011310841096
     [Google Scholar]
  81. (a KulkarniSG MehendaleHM Anxiolytics Encycl Toxicol200521513
     [Google Scholar]
  82. (b KhareRK PrasadAK KumarS IyerSV VaidyaSK BigoniyaP Flavonoid and triterpene rich fraction of dillenia indicalinn. leaves: as anti-inflammatory & anti-arthritic activity.Indo Am J Pharm Res2013346539
     [Google Scholar]
  83. RosangkimaG. RongpiT. PrasadS.B. Ethno-medicinal value of some anticancer medicinal plants from north-east India: an in vivo screening in murine tumor model.Sci. Vis.2010104123132
     [Google Scholar]
  84. KviecinskiM.R. DavidI.M.B. FernandesF.S. CorreaM.R. ClarindaM.M. FreitasA.F. SilvaJ. GavaM. MüllerS.D. FlorentinoD. PetronilhoF. MoterleD. KanisL.A. PedrosaR.C. Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats.Pharm. Biol.201755164164810.1080/13880209.2016.126667227951742
     [Google Scholar]
  85. AswathyM. BanikK. ParamaD. SasikumarP. HarshaC. JosephA.G. SherinD.R. ThanathuM.K. KunnumakkaraA.B. VasuR.K. Exploring the cytotoxic effects of the extracts and bioactive triterpenoids from dillenia indica against oral squamous cell carcinoma: a scientific interpretation and validation of indigenous knowledge.ACS Pharmacol. Transl. Sci.20214283484710.1021/acsptsci.1c0001133860206
     [Google Scholar]
  86. AlamM.B. AhmedA. IslamS. ChoiH.J. MotinM.A. KimS. LeeS.H. Phytochemical Characterization of Dillenia indica L. bark by paper spray ionization-mass spectrometry and evaluation of its antioxidant potential against t-BHP-induced oxidative stress in RAW 264.7 cells.Antioxidants2020911109910.3390/antiox911109933182315
     [Google Scholar]
  87. KumarD. MallickS. VedasiromoniJ.R. PalB.C. Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.Phytomedicine201017643143510.1016/j.phymed.2009.07.01019679456
     [Google Scholar]
  88. KumarS. KumarV. PrakashO. Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract.Braz. J. Pharm. Sci.201147237337810.1590/S1984‑82502011000200018
     [Google Scholar]
  89. SenS. ChakrabortyR. KalitaP. Dillenia indica fruit prevents cisplatin-induced kidney injury in experimental rats through modulation of oxidative stress, marker enzyme, and biochemical changes.Nutrire20184311510.1186/s41110‑018‑0074‑1
     [Google Scholar]
  90. AbdilleM. SinghR. JayaprakashaG. JenaB. Antioxidant activity of the extracts from fruits.Food Chem.200590489189610.1016/j.foodchem.2004.09.002
     [Google Scholar]
  91. PadhyaI.P. ChoudharyN.S.K. PadhyS.K. DashS. Effect of Dillenia indica leaves against carbon tetrachloride induced hepatotoxicity.J Pharm Chem200824190193
     [Google Scholar]
  92. ReddyK.H. TharanathV. ReddyK.B.N. SharmaP.V.G.K. ReddyO.V.S. Studies on hepatoprotective effect of hexane extract of Dillenia indica against CCl4 induced toxicity and its safety evaluation in wistar albino rats.Res. J. Pharm. Biol. Chem. Sci.201013441450
     [Google Scholar]
/content/journals/cddt/10.2174/0115701638292980240407135246
Loading
Harnessing the Therapeutic Potential of Dillenia indica: An Overview of Recent Dosage Form Developments
Current Drug Discovery Technologies 22, E170424229033 (2025); https://doi.org/10.2174/0115701638292980240407135246
/content/journals/cddt/10.2174/0115701638292980240407135246
/content/journals/cddt/10.2174/0115701638292980240407135246
Loading

Data & Media loading...

  • Article Type: Review Article
Keyword(s): emugeland patents; medicinal herbs; microbeads; Mucoadhesive; nasal mucosa; patches

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test