Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Drug Delivery
  4. Volume 22, Issue 4
  5. Article
Volume 22, Issue 4
  • ISSN: 1567-2018
  • E-ISSN: 1875-5704

Abstract

Conjugated Linoleic Acid (CLA) is a polyunsaturated dietary fatty acid. Probiotics can biohydrogenate CLA with multiple health benefits, especially in cancer treatment. , and clinical studies have confirmed CLA isomers to possess anti-cancer activity. CLA has demonstrated its potential as an alternative treatment for cancer and also used as an adjuvant to reduce the side effects of existing treatment methods. The mechanism of the anticancer activity of CLA is still not clear; however, it may involve intervention with the cell cycle and modulation of gene expression. A greater potential of CLA for cancer treatment has been supported by more and more clinical trials to evaluate its potential. Some advanced technologies are in progress to overcome the flaws of current methods and enhance the microbial production of CLA. In conclusion, nutritional enrichment as a functional food and direct consumption of CLA may contribute to cancer management.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cdd/10.2174/0115672018325362240811164655
2024-08-15
2025-05-02

  • From This Site

    /content/journals/cdd/10.2174/0115672018325362240811164655
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. LeeJ. LeeH. KangS. ParkW. Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances.Nutrients2016812310.3390/nu801002326742061
     [Google Scholar]
  2. ShokryazdanP. RajionM.A. MengG.Y. BooL.J. EbrahimiM. RoyanM. SahebiM. AziziP. AbiriR. JahromiM.F. Conjugated linoleic acid: A potent fatty acid linked to animal and human health.Crit. Rev. Food Sci. Nutr.201757132737274810.1080/10408398.2015.106019026252346
     [Google Scholar]
  3. SalsinhaA.S. PimentelL.L. FontesA.L. GomesA.M. Rodríguez-AlcaláL.M. Microbial production of conjugated linoleic acid and conjugated linolenic acid relies on a multienzymatic system.Microbiol. Mol. Biol. Rev.2018824e00019-1810.1128/MMBR.00019‑1830158254
     [Google Scholar]
  4. YangY. TuR. SunW. ZhuZ. ZhangY. Silver perchlorate in the mobile phase for rapid separation and determination of a pair of positional isomers in Inula racemosa Hook.f. with RP-HPLC.J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.20171063253010.1016/j.jchromb.2017.08.01328837869
     [Google Scholar]
  5. TsiafoulisC.G. SkarlasT. TzamaloukasO. MiltiadouD. GerothanassisI.P. Direct nuclear magnetic resonance identification and quantification of geometric isomers of conjugated linoleic acid in milk lipid fraction without derivatization steps: Overcoming sensitivity and resolution barriers.Anal. Chim. Acta2014821627110.1016/j.aca.2014.03.01024703215
     [Google Scholar]
  6. KeplerC.R. HironsK.P. McNeillJ.J. ToveS.B. Intermediates and products of the biohydrogenation of linoleic acid by Butyrinvibrio fibrisolvens.J. Biol. Chem.196624161350135410.1016/S0021‑9258(18)96781‑55936712
     [Google Scholar]
  7. YangB. ChenH. GuZ. TianF. RossR.P. StantonC. ChenY.Q. ChenW. ZhangH. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli.J. Appl. Microbiol.2014117243043910.1111/jam.1252424750362
     [Google Scholar]
  8. PessioneE. Lactic acid bacteria contribution to gut microbiota complexity: Lights and shadows.Front. Cell. Infect. Microbiol.201228610.3389/fcimb.2012.0008622919677
     [Google Scholar]
  9. DachevM. BryndováJ. JakubekM. MoučkaZ. UrbanM. The effects of conjugated linoleic acids on cancer.Processes (Basel)20219345410.3390/pr9030454
     [Google Scholar]
  10. YanaiH. TadaN. Effects of consumption of various fatty acids on serum HDL-cholesterol levels.J. Endocrinol. Metab.201885949910.14740/jem534
     [Google Scholar]
  11. SongK. SongI.B. GuH.J. NaJ.Y. KimS. YangH.S. LeeS.C. HuhC.K. KwonJ. Anti-diabetic effect of fermented milk containing conjugated linoleic acid on Type II diabetes mellitus.Korean J Food Sci Anim Resour201636217017710.5851/kosfa.2016.36.2.17027194924
     [Google Scholar]
  12. DahiyaD.K. PuniyaA.K. Evaluation of survival, free radical scavenging and human enterocyte adherence potential of lactobacilli with anti-obesity and anti-inflammatory CLA isomer-producing attributes.J. Food Process. Preserv.20153962866287710.1111/jfpp.12538
     [Google Scholar]
  13. ViladomiuM. HontecillasR. Bassaganya-RieraJ. Modulation of inflammation and immunity by dietary conjugated linoleic acid.Eur. J. Pharmacol.2016785879510.1016/j.ejphar.2015.03.09525987426
     [Google Scholar]
  14. KimJ. ParkY. LeeS.H. ParkY. trans-10,cis-12 Conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells.J. Nutr. Biochem.201324467267910.1016/j.jnutbio.2012.03.01722832076
     [Google Scholar]
  15. MonacoA. FerrandinoI. BoscainoF. CoccaE. CiglianoL. MauranoF. LuongoD. SpagnuoloM.S. RossiM. BergamoP. Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response.J. Lipid Res.2018591485710.1194/jlr.M07940029167408
     [Google Scholar]
  16. DubeyV. GhoshA.R. BishayeeK. Khuda-BukhshA.R. Appraisal of the anti-cancer potential of probiotic Pediococcus pentosaceus GS4 against colon cancer: In vitro and in vivo approaches.J. Funct. Foods201623667910.1016/j.jff.2016.02.032
     [Google Scholar]
  17. StawarskaA. BiałekA. StanimirovaI. StawarskiT. TokarzA. The effect of conjugated linoleic acids (CLA) supplementation on the activity of enzymes participating in the formation of arachidonic acid in liver microsomes of rats--probable mechanism of CLA anticancer activity.Nutr. Cancer201567114515510.1080/01635581.2015.96787525412117
     [Google Scholar]
  18. ThuillierP. PandeN.T. GhenaA. SongS. LawrenceY. ShridharV. AkkariY. PejovicT. OlsonS. Dietary conjugated linoleic acids arrest cell cycle progression and prevent ovarian cancer xenografts growth suggesting a Trans-10 Cis-12 isoform specific activity.J. Cancer Ther.201345334210.4236/jct.2013.45A006
     [Google Scholar]
  19. BiałekA. ZagrodzkiP. TokarzA. Chemometric analysis of the interactions among different parameters describing health conditions, breast cancer risk and fatty acids profile in serum of rats supplemented with conjugated linoleic acids.Prostaglandins Leukot. Essent. Fatty Acids201610611010.1016/j.plefa.2015.12.00626926361
     [Google Scholar]
  20. HeinzeV.M. ActisA.B. Dietary conjugated linoleic acid and long-chain n -3 fatty acids in mammary and prostate cancer protection: A review.Int. J. Food Sci. Nutr.2012631667810.3109/09637486.2011.59884921762028
     [Google Scholar]
  21. Food and Agricultural Organization of the United Nations and World Health OrganizationHealth and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria.World Health Organization2001
     [Google Scholar]
  22. Legesse BedadaT. FetoT.K. AwokeK.S. GaredewA.D. YifatF.T. BirriD.J. Probiotics for cancer alternative prevention and treatment.Biomed. Pharmacother.202012911040910.1016/j.biopha.2020.11040932563987
     [Google Scholar]
  23. GhoshS. WhitleyC.S. HaribabuB. JalaV.R. Regulation of intestinal barrier function by microbial metabolites.Cell. Mol. Gastroenterol. Hepatol.20211151463148210.1016/j.jcmgh.2021.02.00733610769
     [Google Scholar]
  24. Van NieuwenhoveC.P. OliszewskiR. GonzálezS.N. Pérez ChaiaA.B. Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk.Lett. Appl. Microbiol.200744546747410.1111/j.1472‑765X.2007.02135.x17451511
     [Google Scholar]
  25. GorissenL. RaesK. WeckxS. DannenbergerD. LeroyF. De VuystL. De SmetS. Production of conjugated linoleic acid and conjugated linolenic acid isomers by Bifidobacterium species.Appl. Microbiol. Biotechnol.20108762257226610.1007/s00253‑010‑2713‑120556602
     [Google Scholar]
  26. RaimondiS. AmarettiA. LeonardiA. QuartieriA. GozzoliC. RossiM. Conjugated linoleic acid production by bifidobacteria: Screening, kinetic, and composition.BioMed Res. Int.201620161810.1155/2016/865431727429985
     [Google Scholar]
  27. PallaM. ConteG. GrassiA. EsinS. SerraA. MeleM. GiovannettiM. AgnolucciM. Novel yeasts producing high levels of conjugated linoleic acid and organic acids in fermented doughs.Foods2021109208710.3390/foods1009208734574197
     [Google Scholar]
  28. GorissenL. LeroyF. De VuystL. De SmetS. RaesK. Bacterial production of conjugated linoleic and linolenic acid in foods: A technological challenge.Crit. Rev. Food Sci. Nutr.201555111561157410.1080/10408398.2012.70624324915316
     [Google Scholar]
  29. KuhlG. De Dea LindnerJ. Biohydrogenation of linoleic acid by lactic acid bacteria for the production of functional cultured dairy products: A review.Foods2016511310.3390/foods501001328231108
     [Google Scholar]
  30. HaladeG.V. RahmanM.M. FernandesG. Effect of CLA isomers and their mixture on aging C57Bl/6J mice.Eur. J. Nutr.200948740941810.1007/s00394‑009‑0029‑719424653
     [Google Scholar]
  31. OnakpoyaI.J. PosadzkiP.P. WatsonL.K. DaviesL.A. ErnstE. The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: A systematic review and meta-analysis of randomized clinical trials.Eur. J. Nutr.201251212713410.1007/s00394‑011‑0253‑921990002
     [Google Scholar]
  32. KoronowiczA.A. BanksP. Antitumor properties of CLA-enriched food products.Nutr. Cancer201870452954510.1080/01635581.2018.146068429697270
     [Google Scholar]
  33. BegumJ. BuyamayumB. LingarajuM.C. DevK. BiswasA. Probiotics: Role in immunomodulation and consequent effects.Letters In Animal Biology202111010610.62310/liab.v1i1.53
     [Google Scholar]
  34. LoscherC.E. DraperE. LeavyO. KelleherD. MillsK.H.G. RocheH.M. Conjugated linoleic acid suppresses NF-κ B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction.J. Immunol.200517584990499810.4049/jimmunol.175.8.499016210601
     [Google Scholar]
  35. TangL. LiX.L. DengZ.X. XiaoY. ChengY.H. LiJ. DingH. Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling.J. Nutr. Biochem.20208110837910.1016/j.jnutbio.2020.10837932330842
     [Google Scholar]
  36. TanJ. WanL. ChenX. LiX. HaoX. LiX. LiJ. DingH. Conjugated linoleic acid ameliorates high fructose‐induced hyperuricemia and renal inflammation in rats via nlrp3 inflammasome and TLR4 signaling pathway.Mol. Nutr. Food Res.20196312180140210.1002/mnfr.20180140230913372
     [Google Scholar]
  37. YangC. ZhuB. YeS. FuZ. LiJ. Isomer-Specific Effects of cis-9,trans-11- and trans-10,cis-12-CLA on immune regulation in ruminal epithelial cells.Animals (Basel)2021114116910.3390/ani1104116933921651
     [Google Scholar]
  38. DubeyV. MishraA.K. GhoshA.R. Appraisal of the possible role of PPARγ upregulation by CLA of probiotic Pediococcus pentosaceus GS4 in colon cancer mitigation.PPAR Res.2023202311510.1155/2023/945830836875279
     [Google Scholar]
  39. KimK.J. LeeJ. ParkY. LeeS.H. ATF3 mediates anti-cancer activity of trans-10, cis-12-conjugated linoleic acid in human colon cancer cells.Biomol. Ther. (Seoul)201523213414010.4062/biomolther.2014.10725767681
     [Google Scholar]
  40. BeldaB.J. ThompsonJ.T. SinhaR. PrabhuK.S. HeuvelJ.P.V. The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF2α synthesis in adipocytes.Prostaglandins Other Lipid Mediat.2012991-2303710.1016/j.prostaglandins.2012.05.00122583689
     [Google Scholar]
  41. FlowersM. ThompsonP.A. t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: Possible role of COX2.PLoS One200944e534210.1371/journal.pone.000534219399184
     [Google Scholar]
  42. GrayC. VickersM.H. SegoviaS.A. ZhangX.D. ReynoldsC.M. A maternal high fat diet programmes endothelial function and cardiovascular status in adult male offspring independent of body weight, which is reversed by maternal conjugated linoleic acid (CLA) supplementation.PLoS One2015102e011599410.1371/journal.pone.011599425695432
     [Google Scholar]
  43. MarquesT.M. WallR. O’SullivanO. FitzgeraldG.F. ShanahanF. QuigleyE.M. CotterP.D. CryanJ.F. DinanT.G. RossR.P. StantonC. Dietary trans -10, cis -12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice.Br. J. Nutr.2015113572873810.1017/S000711451400420625697178
     [Google Scholar]
  44. BeluryM.A. Conjugated linoleic acids in Type 2 diabetes mellitus: Implications and potential mechanisms.Advances in Conjugated Linoleic Acid Research.AOCS Publishing202030231510.4324/9780429270703‑19
     [Google Scholar]
  45. Cordoba-ChaconJ. SugasiniD. YalagalaP.C.R. TummalaA. WhiteZ.C. NagaoT. KinemanR.D. SubbaiahP.V. Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice.J. Nutr. Biochem.2019679010010.1016/j.jnutbio.2019.01.02030856468
     [Google Scholar]
  46. Garibay-NietoN. Queipo-GarcíaG. AlvarezF. BustosM. VillanuevaE. RamírezF. LeónM. Laresgoiti-ServitjeE. DuggiralaR. MacíasT. CuevasS. JalifeA. Fonseca-SánchezM. SerratosF. López-AlvarengaJ.C. Effects of conjugated linoleic acid and metformin on insulin sensitivity in obese children: Randomized clinical trial.J. Clin. Endocrinol. Metab.2017102113214010.1210/jc.2016‑270127778642
     [Google Scholar]
  47. MazidiM. KarimiE. RezaieP. FernsG. A. Effects of conjugated linoleic acid supplementation on serum C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.Cardiovasc Ther.201735610.1111/1755‑5922.12275
     [Google Scholar]
  48. KarczewskiJ. Begier-KrasińskaB. StaszewskiR. PopławskaE. Gulczynska-ElhadiK. DobrowolskaA. Obesity and the risk of gastrointestinal cancers.Dig. Dis. Sci.201964102740274910.1007/s10620‑019‑05603‑930968228
     [Google Scholar]
  49. SilveiraE.A. da Silva FilhoR.R. SpexotoM.C.B. HaghighatdoostF. SarrafzadeganN. de OliveiraC. The role of sarcopenic obesity in cancer and cardiovascular disease: A synthesis of the evidence on pathophysiological aspects and clinical implications.Int. J. Mol. Sci.2021229433910.3390/ijms2209433933919368
     [Google Scholar]
  50. AryaeianN. ShahramF. DjalaliM. CLA has a useful effect on bone markers in patients with rheumatoid arthritis.Lipids201651121397140510.1007/s11745‑016‑4201‑627815799
     [Google Scholar]
  51. ChenY. YangB. RossR.P. JinY. StantonC. ZhaoJ. ZhangH. ChenW. Orally administered cla ameliorates dss-induced colitis in mice via intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokine and gut microbiota modulation.J. Agric. Food Chem.20196748132821329810.1021/acs.jafc.9b0574431690068
     [Google Scholar]
  52. SunX. ZhangJ. MacGibbonA.K.H. BlackP. KrissansenG.W. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic dermatitis in mice.Clin. Exp. Allergy201141572973810.1111/j.1365‑2222.2011.03723.x21429050
     [Google Scholar]
  53. PetersonK.M. O’SheaM. StamW. MohedeI.C.M. PatrieJ.T. HaydenF.G. Effects of dietary supplementation with conjugated linoleic acid on experimental human rhinovirus infection and illness.Antivir. Ther.2009141334310.1177/13596535090140011119320235
     [Google Scholar]
  54. TangL. CaoX. LiX. DingH. Topical application with conjugated linoleic acid ameliorates 2, 4‐dinitrofluorobenzene‐induced atopic dermatitis‐like lesions in BALB/c mice.Exp. Dermatol.202130223724810.1111/exd.1424233206422
     [Google Scholar]
  55. KimY. KimJ. WhangKY. ParkY. Impact of Conjugated Linoleic Acid (CLA) on skeletal muscle metabolism.Lipids.20165121597810.1007/s11745‑015‑4115‑8.
     [Google Scholar]
  56. KimY. ParkY. Conjugated linoleic acid (CLA) stimulates mitochondrial biogenesis signaling by the upregulation of PPARγ coactivator 1α (PGC-1α) in C2C12 cells.Lipids201550432933810.1007/s11745‑015‑4000‑525720738
     [Google Scholar]
  57. CucinielloR. LuongoD. MauranoF. CrispiS. BergamoP. Dietary conjugated linoleic acid downregulates the AlCl3-induced hyperactivation of compensatory and maladaptive signalling in the mouse brain cortex.Free Radic. Biol. Med.202421310211210.1016/j.freeradbiomed.2024.01.00638218550
     [Google Scholar]
  58. MurruE. CartaG. MancaC. SogosV. PistisM. MelisM. BanniS. Conjugated linoleic acid and brain metabolism: A possible anti-neuroinflammatory role mediated by PPARα activation.Front. Pharmacol.20211158714010.3389/fphar.2020.58714033505308
     [Google Scholar]
  59. HossainM.S. KaruniawatiH. JairounA.A. UrbiZ. OoiD.J. JohnA. LimY.C. KibriaK.M.K. MohiuddinA.K.M. MingL.C. GohK.W. HadiM.A. Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies.Cancers (Basel)2022147173210.3390/cancers1407173235406504
     [Google Scholar]
  60. ChattopadhyayI. DharR. PethusamyK. SeethyA. SrivastavaT. SahR. SharmaJ. KarmakarS. Exploring the role of gut microbiome in colon cancer.Appl. Biochem. Biotechnol.202119361780179910.1007/s12010‑021‑03498‑933492552
     [Google Scholar]
  61. EvansN.P. MisyakS.A. SchmelzE.M. GuriA.J. HontecillasR. Bassaganya-RieraJ. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.J. Nutr.2010140351552110.3945/jn.109.11564220089779
     [Google Scholar]
  62. DubeyV. GhoshA.R. Probiotics cross talk with multi cell signaling in colon carcinogenesis.J. Probiotics Health2013132510.4172/2329‑8901.1000109
     [Google Scholar]
  63. ParkS.J. KimB.H. KimH.G. KimS.Y. ahC.K. ChoY.U. KimG.S. HaY.L. Anti-proliferative efficacy comparison of conjugated linoleic acid on human cancer cell lines.J. Biomed. Res. (Cheongju)201314424024810.12729/jbr.2013.14.4.240
     [Google Scholar]
  64. OraldiM. MaggioraM. PaiuzziE. CanutoR.A. MuzioG. CLA reduces inflammatory mediators from A427 human lung cancer cells and A427 conditioned medium promotes differentiation of C2C12 murine muscle cells.Lipids2013481293810.1007/s11745‑012‑3734‑623129255
     [Google Scholar]
  65. IslamM.A. KimY.S. OhT.W. KimG.S. WonC.K. KimH.G. ChoiM.S. KimJ.O. HaY.L. Superior anticarcinogenic activity of trans,trans-conjugated linoleic acid in N-methyl-N-nitrosourea-induced rat mammary tumorigenesis.J. Agric. Food Chem.20105895670567810.1021/jf100117a20373764
     [Google Scholar]
  66. KimD.I. KimK.H. KangJ.H. JungE.M. KimS.S. JeungE.B. YangM.P. Trans -10, cis -12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway.Br. J. Nutr.201110591329133610.1017/S000711451000499X21205430
     [Google Scholar]
  67. DegenC. EckerJ. PiegholdtS. LiebischG. SchmitzG. JahreisG. Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA.Biochim. Biophys. Acta Mol. Cell Biol. Lipids20111811121070108010.1016/j.bbalip.2011.08.00521889998
     [Google Scholar]
  68. ZhongX.F. LuoT. HuangG.D. DengZ.Y. LeiL. Equimolar mixture of c9,t11 and t9,t11 CLA inhibits the growth and induces apoptosis in Caco‐2 cells.Eur. J. Lipid Sci. Technol.2012114447948510.1002/ejlt.201100338
     [Google Scholar]
  69. El RozA. BardJ.M. HuvelinJ.M. NazihH. The anti-proliferative and pro-apoptotic effects of the trans9,trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation.Prostaglandins Leukot. Essent. Fatty Acids201388426527210.1016/j.plefa.2012.12.00623375583
     [Google Scholar]
  70. BoniC. SorioC. The role of the tumor suppressor gene protein tyrosine phosphatase gamma in cancer.Front. Cell Dev. Biol.2022976896910.3389/fcell.2021.76896935071225
     [Google Scholar]
  71. PierreA.S. Minville-WalzM. FèvreC. HichamiA. GrestiJ. PichonL. BellengerS. BellengerJ. GhiringhelliF. NarceM. RiallandM. Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.Biochim. Biophys. Acta Mol. Cell Biol. Lipids20131831475976810.1016/j.bbalip.2013.01.00523333652
     [Google Scholar]
  72. KoronowiczA.A. DrozdowskaM. BanksP. Piasna-SłupeckaE. DomagałaD. LeszczyńskaT. Fatty acids of CLA-enriched egg yolks can induce mitochondrial pathway of apoptosis in MCF-7 breast cancer cells.Anticancer Res.20183852861287010.21873/anticanres.1253129715109
     [Google Scholar]
  73. KadirareddyR.H. VemuriS.G. PalempalliU.M. Probiotic conjugated linoleic acid mediated apoptosis in breast cancer cells by downregulation of NFκB.Asian Pac. J. Cancer Prev.20161773395340327509982
     [Google Scholar]
  74. LuG. ZhangG. ZhengX. ZengY. XuZ. ZengW. WangK. c9, t11- conjugated linoleic acid induces HCC cell apoptosis and correlation with PPAR-γ signaling pathway.Am. J. Transl. Res.20157122752276326885272
     [Google Scholar]
  75. ThavasurajS. NithyaV. Evaluation on efficacy of fatty acids and conjugated linoleic acid [CLA] derived from indegenous cow milk against hepato cellular carcinoma: A key and novel approach.Biochem. Cell. Arch.202020
     [Google Scholar]
  76. LiuY. BianY. LuoX. WangC. MuD. PanG. WuJ. ShiH. Synergistic effect of docosahexaenoic acid or conjugated linoleic acid with caffeic acid on ameliorating oxidative stress of HepG2 cells.J. Food Sci.20218673240325110.1111/1750‑3841.1577534118075
     [Google Scholar]
  77. ShahzadM.M.K. FelderM. LudwigK. Van GalderH.R. AndersonM.L. KimJ. CookM.E. KapurA.K. PatankarM.S. Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src.PLoS One2018131e018952410.1371/journal.pone.018952429324748
     [Google Scholar]
  78. DomagałaD. LeszczyńskaT. KoronowiczA. DomagałaB. DrozdowskaM. Piasna-SłupeckaE. Mechanisms of anticancer activity of a fatty acid mixture extracted from hen egg yolks enriched in conjugated linoleic acid diene (CLA) against WM793 melanoma cells.Nutrients2021137234810.3390/nu1307234834371857
     [Google Scholar]
  79. GrishinaA. KulikovaI. AlievaL. DodsonA. RowlandI. JinJ. Antigenotoxic effect of kefir and ayran supernatants on fecal water-induced DNA damage in human colon cells.Nutr. Cancer2010631110.1080/01635581.2010.51687321161824
     [Google Scholar]
  80. SukumarG. GhoshA.R. Pediococcus spp. A potential probiotic isolated from khadi (an Indian fermented food) and identified by 16S rDNA sequence analysis.Afr. J. Food Sci.20104959760210.5897/ajfs.9000216
     [Google Scholar]
  81. DubeyV. GhoshA.R. MandalB.K. Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4.Appl. Biochem. Biotechnol.201216851265127610.1007/s12010‑012‑9855‑922971829
     [Google Scholar]
  82. MoreiraT.G. HortaL.S. Gomes-SantosA.C. OliveiraR.P. QueirozN.M.G.P. ManganiD. DanielB. VieiraA.T. LiuS. RodriguesA.M. GomesD.A. GabrielyG. FerreiraE. WeinerH.L. RezendeR.M. NagyL. FariaA.M.C. CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells.Mucosal Immunol.201912118819910.1038/s41385‑018‑0090‑830279515
     [Google Scholar]
  83. PengJ. HanS. ChenZ. YangJ. PeiY. BaoC. QiaoL. ChenW. LiuB. Chaperone-mediated autophagy regulates apoptosis and the proliferation of colon carcinoma cells.Biochem. Biophys. Res. Commun.2020522234835410.1016/j.bbrc.2019.11.08131761324
     [Google Scholar]
  84. Bassaganya-RieraJ. ViladomiuM. PedragosaM. De SimoneC. HontecillasR. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria.PLoS One201274e3467610.1371/journal.pone.003467622511958
     [Google Scholar]
  85. JelińskaM. BiałekA. GielecińskaI. MojskaH. TokarzA. Impact of conjugated linoleic acid administered to rats prior and after carcinogenic agent on arachidonic and linoleic acid metabolites in serum and tumors.Prostaglandins Leukot. Essent. Fatty Acids20171261810.1016/j.plefa.2017.08.01329031386
     [Google Scholar]
  86. BiałekM. BiałekA. CzaudernaM. Conjugated linoleic acid isomers affect profile of lipid compounds and intensity of their oxidation in heart of rats with chemically-induced mammary tumors—preliminary study.Nutrients2019119203210.3390/nu1109203231480307
     [Google Scholar]
  87. ZengY. LiuP. YangX. LiH. LiH. GuoY. MengX. LiuX. The dietary c 9, t 11-conjugated linoleic acid enriched from butter reduces breast cancer progression in vivo.J. Food Biochem.2020444e1316310.1111/jfbc.1316332030801
     [Google Scholar]
  88. Abd El-GawadA.M. Abo El-HassanD.G. Aboul-EneinA.M. AbdelgayedS.S. AlyS.A. EsmatG. MostafaA.A. BakrM.H. AliR.A. AyoubM.A. Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice.Vet. World202114369670810.14202/vetworld.2021.696‑70833935416
     [Google Scholar]
  89. LarssonS.C. BergkvistL. WolkA. High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish mammography cohort.Am. J. Clin. Nutr.200582489490010.1093/ajcn/82.4.89416210722
     [Google Scholar]
  90. MohammadzadehM. FaramarziE. MahdaviR. NasirimotlaghB. Asghari JafarabadiM. Effect of conjugated linoleic acid supplementation on inflammatory factors and matrix metalloproteinase enzymes in rectal cancer patients undergoing chemoradiotherapy.Integr. Cancer Ther.201312649650210.1177/153473541348541723632235
     [Google Scholar]
  91. ChajèsV. LavillonnièreF. FerrariP. JourdanM.L. PinaultM. MaillardV. SébédioJ.L. BougnouxP. Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients.Cancer Epidemiol. Biomarkers Prev.200211767267312101117
     [Google Scholar]
  92. VoorripsL.E. BrantsH.A.M. KardinaalA.F.M. HiddinkG.J. van den BrandtP.A. GoldbohmR.A. Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: The Netherlands cohort study on diet and cancer.Am. J. Clin. Nutr.200276487388210.1093/ajcn/76.4.87312324303
     [Google Scholar]
  93. McCannS.E. IpC. IpM.M. McGuireM.K. MutiP. EdgeS.B. TrevisanM. FreudenheimJ.L. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study).Cancer Epidemiol. Biomarkers Prev.20041391480148410.1158/1055‑9965.1480.13.915342449
     [Google Scholar]
  94. ChajèsV. LavillonnièreF. MaillardV. GiraudeauB. JourdanM.L. SébédioJ.L. BougnouxP. Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis.Nutr. Cancer2003451172310.1207/S15327914NC4501_212791500
     [Google Scholar]
  95. AroA. MännistöS. SalminenI. OvaskainenM.L. KatajaV. UusitupaM. Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women.Nutr. Cancer200038215115710.1207/S15327914NC382_211525591
     [Google Scholar]
  96. McGowanM.M. EisenbergB.L. LewisL.D. FroehlichH.M. WellsW.A. EastmanA. KuemmerleN.B. RosenkrantzK.M. BarthR.J.Jr SchwartzG.N. LiZ. TostesonT.D. BeaulieuB.B.Jr KinlawW.B. A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue.Breast Cancer Res. Treat.2013138117518310.1007/s10549‑013‑2446‑923417336
     [Google Scholar]
  97. MármolI. Sánchez-de-DiegoC. Pradilla DiesteA. CerradaE. Rodriguez YoldiM. Colorectal carcinoma: A general overview and future perspectives in colorectal cancer.Int. J. Mol. Sci.201718119710.3390/ijms1801019728106826
     [Google Scholar]
  98. SahB.N.P. VasiljevicT. McKechnieS. DonkorO.N. Effect of probiotics on antioxidant and antimutagenic activities of crude peptide extract from yogurt.Food Chem.201415626427010.1016/j.foodchem.2014.01.10524629967
     [Google Scholar]
  99. BenjaminS. PrakasanP. SreedharanS. WrightA.D.G. SpenerF. Pros and cons of CLA consumption: An insight from clinical evidences.Nutr. Metab. (Lond.)2015121410.1186/1743‑7075‑12‑425972911
     [Google Scholar]
  100. WatkinsB.A. LiY. CLA in functional food: Enrichment of animal products.Advances in Conjugated Linoleic Acid Research.AOCS Publishing202017418810.4324/9780429270703‑11
     [Google Scholar]
  101. ShinnS.E. RuanC.M. ProctorA. Strategies for producing and incorporating conjugated linoleic acid–rich oils in foods.Annu. Rev. Food Sci. Technol.20178118120410.1146/annurev‑food‑030216‑02570328245153
     [Google Scholar]
  102. ImatoukeneN. VerbekeJ. BeopoulosA. Idrissi TaghkiA. ThomassetB. SardeC.O. NonusM. NicaudJ.M. A metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast Yarrowia lipolytica.Appl. Microbiol. Biotechnol.2017101114605461610.1007/s00253‑017‑8240‑628357546
     [Google Scholar]
/content/journals/cdd/10.2174/0115672018325362240811164655
Loading
Conjugated Linoleic Acid in Cancer Therapy
Curr. Drug Deliv. 22, 450 (2025); https://doi.org/10.2174/0115672018325362240811164655
/content/journals/cdd/10.2174/0115672018325362240811164655
/content/journals/cdd/10.2174/0115672018325362240811164655
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): biohydrogenation; cancer; CLA; functional food; prevention; Probiotics

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test