Combinatorial Chemistry & High Throughput Screening - Volume 23, Issue 5, 2020

Aim and Objective: In the last decades, cancer has become a major problem in public health all around the globe. Chimeric chemical structures have been established as an important trend on medicinal chemistry in the last years. Thiazacridines are hybrid molecules composed of a thiazolidine and acridine nucleus, both pharmacophores that act on important biological targets for cancer. By the fact it is a serious dis Read More

Background: Neonatal sepsis is a serious and difficult-to-diagnose systemic infectious disease occurring during the neonatal period. Objective: This study aimed to identify potential biomarkers of neonatal sepsis and explore its underlying mechanisms. Methods: We downloaded the neonatal sepsis-related gene profile GSE25504 from the NCBI Gene Expression Omnibus (GEO) database. The differentially expressed RNAs (DERs Read More

Background: Tumor microenvironment (TME) cells play important roles in tumor progression. Accumulating evidence show that they can be exploited to predict the clinical outcomes and therapeutic responses of the tumor. However, the role of immune genes of TME in small cell lung cancer (SCLC) is currently unknown. Objective: To determine the role of immune genes in SCLC. Methods: We downloaded the expressio Read More

Background: Since the last few decades, the healthcare sector is facing the problem of the development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections all over the world. Regardless of the current healthcare progress for the treatment of mycobacterial infections, we are still unable to control addition of every year 9 million new cases of tuberculosis (TB). Objective: We had Read More

Aim and Objective: The Dendrobium officinalis flower (DOF) is popular in China due to common belief in its anti-aging properties and positive effects on “nourish yin”. However, there have been relatively few confirmatory pharmacological experiments conducted to date. The aim of this work was to evaluate whether DOF has beneficial effects on learning and memory in senescent rats, and, if so, to determine its potential mechani Read More

Background: Osteosarcoma is one of the most serious primary malignant bone tumors that threaten the lives of children and adolescents. However, the mechanism underlying and how to prevent or treat the disease have not been well understood. Aims and Objective: This aim of the present study was to identify the key genes and explore novel insights into the molecular mechanism of miR-542-3p over-expressed Ost Read More

Aims and Objective: The common disease of insomnia has complex and diverse clinical manifestations. Lavender represents an effective treatment of insomnia, but the molecular mechanism underlying the effectiveness of this treatment is not clear. The purpose of this study is to investigate the active components, target proteins and molecular pathways of lavender in the treatment of insomnia, thus explaining its possible mech Read More

Aims and Objective: This paper aims to reveal the useful industrial aspects of kandite and montmorillonite group of clays using as a catalyst after acid activation. A comparative study of modified characteristics of clay samples has been explored based on industrial requirements. Materials and Methods: In this study sodium bentonite and kaolin clay have been focused. The modified characteristics of clay samples are investigate Read More

Aims and Objective: In this work, pyran derivatives were synthesized via a multicomponent reaction of ninhydrin, α-haloketones, dialkyl acetylenedicarboxylate, and triphenylphosphine in the presence of iron oxide magnetic nanoparticles (Fe3O4-MNPs) as efficient nanocatalyst in ethanol at room temperature. Materials and Methods: The biosynthesis of Fe3O4-MNPs was performed by Clover Leaf water extract. In Read More