Combinatorial Chemistry & High Throughput Screening - Volume 22, Issue 10, 2019

Background: Human rhinovirus has different identified serotypes and is the most common cause of cold in humans. To date, many genes have been discovered to be related to rhinovirus infection. However, the pathogenic mechanism of rhinovirus is difficult to elucidate through experimental approaches due to the high cost and consuming time. Methods and Results: In this study, we presented a novel approach that relies on Read More

Background and Objective: Blue rubber bleb nevus syndrome (BRBN) or Bean syndrome is a rare Venous Malformation (VM)-associated disorder, which mostly affects the skin and gastrointestinal tract in early childhood. Somatic mutations in TEK have been identified from BRBN patients; however, the etiology of TEK mutation-negative patients of BRBN need further investigation. Methods: Two unrelated sporadic BRBNs an Read More

Background: Genes are known as functional patterns in the genome and are presumed to have biological significance. They can indicate binding sites for transcription factors and they encode certain proteins. Finding genes from biological sequences is a major task in computational biology for unraveling the mechanisms of gene expression. Objective: Planted motif finding problems are a class of mathematical models abstr Read More

Aims and Objective: Cancer is one of the deadliest diseases, taking the lives of millions every year. Traditional methods of treating cancer are expensive and toxic to normal cells. Fortunately, anti-cancer peptides (ACPs) can eliminate this side effect. However, the identification and development of new anti-cancer peptides through experiments take a lot of time and money, therefore, it is necessary to develop a fast Read More

Background: Citrullination, an important post-translational modification of proteins, alters the molecular weight and electrostatic charge of the protein side chains. Citrulline, in protein sequences, is catalyzed by a class of Peptidyl Arginine Deiminases (PADs). Dependent on Ca2+, PADs include five isozymes: PAD 1, 2, 3, 4/5, and 6. Citrullinated proteins have been identified in many biological and pathological processes. A Read More

Aims and Objective: The magic scaffolds rhodanine and thiazolidine are very important heterocyclic compounds in drug design and discovery. Those are important heterocyclic compounds that have attracted a great deal of attention due to the fact that they exhibit a variety of bioactivities including antibacterial, antifungal, antiviral, antimalarial, and anti-inflammatory activities. These agents often exhibit selective toxicity. T Read More

Objective: KF/Clinoptilolite nanoparticles are employed as a heterogeneous catalyst for the preparation of pyrido[2,1-a]isoquinoline derivatives through a four-component reaction of isoquinoline, two different alkyl bromides and an electron deficient internal alkynes at ambient temperature in water as green solvent. Methods: In this research, (2,2-Diphenyl-1-picrylhydrazyl) radical trapping and reducing potential of ferric ion Read More