Combinatorial Chemistry & High Throughput Screening - Volume 15, Issue 2, 2012

As populations increase and economic growth, industrialization, and modernization spread throughout the world, Green Chemistry is emerging as a subject of utmost importance. Some of its most significant and diverse applications include the development of chemical processes that are more energy efficient and environmentally sound, save valuable raw materials, control emissions, and produce less hazardous byproducts. Wo Read More

Effects of different catalyst components on the catalytic performance in steam reforming of ethanol have been investigated by means of Artificial Neural Networks (ANNs) and Partial Least Square regression (PLSR). The data base consisted of ca. 400 items (catalysts with varied composition), which were obtained from a former catalyst optimization procedure. Marten's uncertainty (jackknife) test showed that simultaneous add Read More

The Temkin reactor concept was successfully extended to the high throughput operation mode and it could be considerably improved as compared to the original design with respect to an optimized gas flow pattern over the full size beads. This improved parallel reactor design was successfully used for the high throughput optimization of an innovative new class of physically coated VAM shell catalysts. Exploiting this novel, impro Read More

Renewable feedstocks have been in the spotlight of intensive research activities over the past 10 years. Glycerol is one of the feedstock molecules which has been the target of numerous research efforts, for a number of reasons. First of all glycerol is currently readily available due to the fact that it is a couple product of the first generation biodiesel production. Secondly glycerol can be taken as a representative model substrat Read More

The oxidation of o-xylene and/or naphthalene to phthalic anhydride is one of the important industrial processes based on catalytic selective oxidation reactions. Vanadia - titania catalysts have been used in the industrial phthalic anyhdride process for the last 50 years. The operation parameters like the temperature range of operation, reactor inlet pressures, contact times, o-xylene loadings, etc. were constantly impr Read More

Transition-metal-free oxides were studied as heterogeneous catalysts for the sustainable epoxidation of alkenes with aqueous H2O2 by means of high throughput experimentation (HTE) techniques. A full-factorial HTE approach was applied in the various stages of the development of the catalysts: the synthesis of the materials, their screening as heterogeneous catalysts in liquid-phase epoxidation and the optimisation of t Read More

Combinatorial screening using precipitation methods at room temperature can lead to a great diversity of carboxylate based Metal Organic Frameworks (MOFs) including already known or original porous solids. The investigation of the synthesis of MOFs in different solvent and solvent mixtures includes the use of solvents such as alcohols and tetrahydrofuran (THF) which would greatly facilitate large scale production. W Read More

Technically relevant partial oxidation reactions represent complex reaction networks. Establishing a kinetic model for a system of multiple consecutive and parallel reaction steps is a challenging goal. The synthesis of acrylic acid by oxidation of propane using MoVTeNb mixed oxide as catalyst is such a reaction network. In an on-going study, a 10- fold parallel reactor set-up is used to vary systematically reaction conditi Read More

Supported Ionic Liquid Phase (SILP) catalysts have been prepared by effective immobilization of [Cu(TMEDA)(OH)]Cl in a nano-metric film of an ionic liquid on various oxidic support materials. The catalysts were tested for the oxidative homocoupling of 1-alkynes to the corresponding diynes in in a combined high throughput and conventional batch reaction approach. Among the screened support materials silica based materials per Read More

High Throughput experimentation has been well established as a tool in early stage catalyst development and catalyst and process scale-up today. One of the more challenging areas of catalytic research is polymer catalysis. The main difference with most non-polymer catalytic conversions is the fact that the product is not a well defined molecule and the catalytic performance cannot be easily expressed only in terms of cataly Read More

Successful implementation of High throughput Experimentation (EE) tools has resulted in their increased acceptance as essential tools in chemical, petrochemical and polymer R&D laboratories. This article provides a number of concrete examples of EE systems, which have been designed and successfully implemented in studies, which focus on deriving reaction kinetic data. The implementation of high throughput EE tools for p Read More

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