Combinatorial Chemistry & High Throughput Screening - Volume 14, Issue 3, 2011

Nanotechnology refers to the creation of functional materials, devices, and systems through the control of matter at the nanometer scale, and the exploitation of novel phenomena and properties at that scale. Advances in nanotechnology will have tremendous impacts on every aspect of our society. The discovery and optimization of novel functional nanomaterials with unique properties require a time-consuming research eff Read More

Catalyst investigation is a typical “trial and error” process. In order to discover a good catalyst, people usually test a huge number of potential catalyst candidates. High throughput experimentation (HTE) is an efficient methodology for catalyst discovery and optimization. HTE is capable of synthesizing and testing hundreds of catalysts in a short period of time. And it is now becoming a widely applied tool in catalyst discover Read More

The last decade has seen significant progresses in the application of combinatorial approaches and high throughput screening in photocatalyst discovery. This paper aims at providing a comprehensive review on the parallel synthesis and high throughput characterization of photocatalysts, including the development of instrumentation, strategy of experiment, preparation of libraries, high throughput screening technique and Read More

Over the past two decades, glycosylated nanoparticles (i.e., glyconanoparticles having sugar residues on the surface) received much attention for biomedical applications such as bioassays and targeted drug delivery. This minireview focuses on three aspects: (1) glycosylated gold nanoparticles, (2) glycosylated quantum dots, and (3) glyconanoparticles self-assembled from amphiphilic glycopolymers. The synthetic methods and t Read More

Due to the unique properties, such as their large surface to volume ratio and easy modification, nanomaterials have recently been studied as effective sorbents in the field of separation science. It has proven to be more effective and efficient to use nanoparticles (NPs) as a stationary phase in solid-phase extraction separation. In addition, NPs can be also used as buffer additives in capillary electrophoresis separation. T Read More

Chemical modifications of nanoparticle's (NP's) surfaces can be used to regulate their activities, remove their toxic effects, and enable them to perform desired functions. Similar to SPS samples, modified NPs also have smallmolecules on the surface of a solid support. The need to monitor synthesis, optimize reaction conditions, and characterize the products is quite similar in both situations. FTIR, NMR, MS and other analyti Read More

The objective of this paper is to examine the challenges and opportunities in high throughput screening of atomic scale chemistry via a technique known as atom probe tomography. While there are numerous methods that exist in the field of throughput screening, even at the nanoscale, most of the effort is on screening properties, rather than chemistry and/or structure. In this overview, we discuss the role atom probe tomogr Read More

The aim of this review is to describe and to analyze the ingredients that are necessary in order to develop a robust and effective experimental approach for the high throughput characterization of protein-nanostructured surface interaction. In the first part of this paper we review the nanostructured surface synthesis methods that are potentially able to create nanostructured inorganic surface libraries. In the second p Read More

Evaluation of desired and undesired, biological effects of Manufactured NanoParticles (MNPs) is of critical importance for the future of nanotechnology. Experimental studies, especially toxicological, are time-consuming and costly, calling for the development of efficient computational tools capable of predicting biological events caused by MNPs from their structures and physical chemical properties. This Read More

Bing Yan got his Ph.D. from Columbia University in 1990 and carried out postdoctoral research at University of Cambridge, U.K. and University of Texas Medical School in Houston from 1990 to 1993. From 1993 to 2005, he worked at Novartis in New Jersey, Discovery Partners International in South San Francisco, and Bristol-Myers Squibb in Connecticut. Now he is a Full Member at Department of Chemical Biology and Therape Read More