Combinatorial Chemistry & High Throughput Screening - Volume 10, Issue 9, 2007

Microwave irradiation has become a widely accepted unconventional energy source for performing organic reactions. Microwave heating is very attractive for chemical applications as it produces a rapid and volumetric heating of samples that depends strongly on the properties of the material. In contrast, conventional heating is slow, superficial and less dependent on the properties of the material. In the period followi Read More

Microwave-assisted organic synthesis is an enabling technology that has been exploited for a variety of applications including medicinal chemistry/drug discovery projects where speed is often a critical factor. In this review, applications of microwave-assisted organic synthesis employing a parallel processing regime are summarized. Examples include parallel synthesis in domestic microwave ovens, the use of s Read More

Biotechnology has recently celebrated 30 years both as a science and as a multi-billion dollar industry. One application of biotechnology is to use human genetic information to discover, develop, manufacture, and commercialize biotherapeutics. Recombinant proteins can be produced in large quantities at high purity. High-throughput proteomic analysis is at the heart of the biotechnology research and development process, an Read More

Microwave irradiation is an important tool in the functionalization of fullerenes and carbon nanotubes. These are compounds with excellent properties that make them useful for the development of optoelectronic organic devices. The applications of microwaves in the chemistry of these materials are reviewed.

A microwave-enhanced, palladium-catalyzed protocol for the α-arylation of a protected glycine in neat water is described. This reaction proceeds rapidly, under non-inert conditions, to afford a range of phenylglycine derivatives in moderate to good yields. Based on this α-arylation, a number of aryl L-methionine-SR-sulfoximine (MSO) analogues were prepared and evaluated for their Mycobacterium tuberculosis glutamine synt Read More

Microwave-assisted Suzuki-Miyaura and Stille cross-coupling reactions for the synthesis of highly electronrich and diversely functionalized biaryl intermediates are presented. Microwave-irradiation has been demonstrated to be a very powerful tool for performing difficult transition metal-catalyzed cross-coupling reactions with unfavorably substituted coupling partners. The key biaryl intermediates were used for the micro Read More