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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 16, Issue 10, Dec 2013, p. 858 - 864
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- 01 Dec 2013
Abstract
A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.
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