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Volume 27, Issue 19
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Background

Dragon's blood is widely consumed in China, Vietnam and Laos to promote blood circulation. A Compound Dragon's blood capsule (CDC) is a patented medicine composed of dragon’s blood, notoginseng, and borneol. This combination is purported to stabilize coronary heart disease and myocardial ischemia. However, the possible mechanisms and the characterization of its drug targets’ relevance at the systemic level remain unclear.

Aim

The present study aims to reveal the potential mechanisms of CDC’s anti-myocardial ischemia effect.

Materials and Methods

The potential mechanisms were investigated by network pharmacology and qRT-PCR was used to verify the expression levels of key genes of PI3k-Akt pathway.

Results

S1PR2 and AGTR1 were the common targets, which involved 6 biological processes annotated by KEGG and GO analysis. The qRT-PCR results showed a remarkable increase in the expression of and . Results also showed a decline in the expression of and after CDC intervention.

Conclusion

CDC has a significant anti-myocardial ischemia effect through the PI3k/Akt pathway, which demonstrates that CDC is a suitable adjuvant to treat CHD and provides a theoretical basis for its further clinical application.

© 2024 Bentham Science Publishers
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2024-12-01
2024-11-22

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Investigation of the Potential Mechanism of Compound Dragon's Blood Capsule against Myocardial Ischemia Based on Network Pharmacology
Comb Chem High Throughput Screen 27, 2940 (2024); https://doi.org/10.2174/0113862073264485240102064653
/content/journals/cchts/10.2174/0113862073264485240102064653
/content/journals/cchts/10.2174/0113862073264485240102064653
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  • Article Type:     Research Article
Keyword(s): Compound dragon's blood capsule; mTOR; myocardial ischemia; network pharmacology; Pi3k-akt pathway; ROS

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