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Volume 28, Issue 1
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Objective

To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the postoperative nutritional status and recovery of gastrointestinal function in colorectal cancer patients.

Methods

Sixty-five patients with ASA grade I-II, undergoing laparoscopic radical colorectal cancer surgery under elective general anesthesia were selected. They were divided into two groups according to the random number table method: the TEAS group (T group) and the sham stimulation group (S group). Two groups of patients were given separate transcutaneous electrical acupoint stimulation and sham stimulation for 30 min at the Hegu (LI4), Neiguan (PC6), Zusanli (ST36), Shangjuxu (ST37), Xiajuxu (ST39), and Sanyinjiao (SP6) points. The intervention time point from the day before surgery, 30 minutes before the start of anesthesia induction, at the start of skin incision, and at the end of surgery to the first, second, and third postoperative days. Changes in serum total protein (TP), albumin (ALB), prealbumin (PA), and transferrin (TRF) were observed, postoperative recovery of gastrointestinal function, and the incidence of postoperative complications were observed.

Results

There was no statistical difference between the general data of the two groups; TP, ALB, PA, and TRF in both groups decreased significantly (0.05) on postoperative day 1 and 3 compared with those on preoperative day 1. TP, ALB, PA, and TRF were significantly higher in patients in group T than in group S on postoperative days 3 and 7, and the differences were statistically significant (0.05). The time to first ventilation, time to defecation, and time to liquid diet were all significantly shorter in group T than in group S. The difference was statistically significant (0.05). The incidence of postoperative nausea, vomiting, and abdominal distension was significantly lower in group T than in group S, with a significant statistical difference (0.05).

Conclusion

Transcutaneous electrical acupoint stimulation can improve postoperative serum protein levels and promote postoperative early recovery in patients with colorectal cancer.

© 2025 Bentham Science Publishers
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2025-01-19

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References

  1. KarthausM. FrielerF. Eating and drinking at the end of life: Nutritional support for cancer patients in palliative care.Wien. Med. Wochenschr.20041549-1019219810.1007/s10354‑004‑0065‑0 15244044
     [Google Scholar]
  2. LoboD.N. GianottiL. AdiamahA. BarazzoniR. DeutzN.E.P. DhatariyaK. GreenhaffP.L. HiesmayrM. Hjort JakobsenD. KlekS. KrznaricZ. LjungqvistO. McMillanD.C. RollinsK.E. PanisicS.M. SkipworthR.J.E. StangaZ. StockleyA. StockleyR. WeimannA. Perioperative nutrition: Recommendations from the ESPEN expert group.Clin. Nutr.202039113211322710.1016/j.clnu.2020.03.038 32362485
     [Google Scholar]
  3. LidorikiI. SchizasD. MylonasK.S. Postoperative changes in nutritional and functional status of gastroesophageal cancer patients.J. Am. Coll. Nutr.2021413301309 33704025
     [Google Scholar]
  4. MontomoliJ. ErichsenR. AntonsenS. NilssonT. SørensenH.T. Impact of preoperative serum albumin on 30-day mortality following surgery for colorectal cancer: a population-based cohort study.BMJ Open Gastroenterol.201521e00004710.1136/bmjgast‑2015‑000047 26462287
     [Google Scholar]
  5. GeX. DaiX. DingC. TianH. YangJ. GongJ. ZhuW. LiN. LiJ. Early postoperative decrease of serum albumin predicts surgical outcome in patients undergoing colorectal resection.Dis. Colon Rectum201760332633410.1097/DCR.0000000000000750 28177996
     [Google Scholar]
  6. KotaniN. HashimotoH. SatoY. SesslerD.I. YoshiokaH. KitayamaM. YasudaT. MatsukiA. Preoperative intradermal acupuncture reduces postoperative pain, nausea and vomiting, analgesic requirement, and sympathoadrenal responses.Anesthesiology200195234935610.1097/00000542‑200108000‑00015 11506105
     [Google Scholar]
  7. ShanJ.G. XueS. XuG.X. WangW.J. LianF. LiuS. HuZ.L. HuangR.T. Effects of acupuncture-drug compound anesthesia on perioperative inflammatory factors in patients undergoing cardiac surgery.Zhongguo Zhenjiu2010307585588 20862944
     [Google Scholar]
  8. TongM.L. NiJ. WengN. Acupuncture improving hand grip strength and nutrition in CAPD patients.J. Tradit. Chin. Med.2015330716381640
     [Google Scholar]
  9. FangJ. WangX.J. LiY.X. Effect of transcutaneous electrical stimulation of acupuncture points on enteral nutrition in critically ill patients.Zhongguo Xiandai Zhongyao2020220516911696
     [Google Scholar]
  10. GangadharanA. ChoiS.E. HassanA. AyoubN.M. DuranteG. BalwaniS. KimY.H. PecoraA. GoyA. SuhK.S. Protein calorie malnutrition, nutritional intervention and personalized cancer care.Oncotarget2017814240092403010.18632/oncotarget.15103 28177923
     [Google Scholar]
  11. LiuL.J. WuX.L. WangY.J. Subjective comprehensive assessment of nutritional screening for predicting postoperative complications in colon cancer.J. Pract. Med.2018341525602563
     [Google Scholar]
  12. NorbergÅ. RooyackersO. SegersvärdR. WernermanJ. Albumin kinetics in patients undergoing major abdominal surgery.PLoS One2015108e013637110.1371/journal.pone.0136371 26313170
     [Google Scholar]
  13. HülshoffA. SchrickerT. ElgendyH. HatzakorzianR. LattermannR. Albumin synthesis in surgical patients.Nutrition201329570370710.1016/j.nut.2012.10.014 23333435
     [Google Scholar]
  14. RussellJ.A. Management of sepsis.N. Engl. J. Med.2006355161699171310.1056/NEJMra043632 17050894
     [Google Scholar]
  15. O’DwyerM.J. OwenH.C. TorranceH.D.T. The perioperative immune response.Curr. Opin. Crit. Care201521433634210.1097/MCC.0000000000000213 26103142
     [Google Scholar]
  16. WierdakM. PisarskaM. Kuśnierz-CabalaB. WitowskiJ. DworakJ. MajorP. MałczakP. CeranowiczP. BudzyńskiA. PędziwiatrM. Changes in plasma albumin levels in early detection of infectious complications after laparoscopic colorectal cancer surgery with ERAS protocol.Surg. Endosc.20183273225323310.1007/s00464‑018‑6040‑4 29340818
     [Google Scholar]
  17. PessauxP. MsikaS. AtallaD. HayJ.M. FlamantY. Risk factors for postoperative infectious complications in noncolorectal abdominal surgery: A multivariate analysis based on a prospective multicenter study of 4718 patients.Arch. Surg.2003138331432410.1001/archsurg.138.3.314 12611581
     [Google Scholar]
  18. LohsiriwatV. LohsiriwatD. BoonnuchW. ChinswangwatanakulV. AkaraviputhT. Lert-akayamaneeN. Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery.World J. Gastroenterol.20081481248125110.3748/wjg.14.1248 18300352
     [Google Scholar]
  19. TashiroT. YamamoriH. TakagiK. MorishimaY. NakajimaN. Effect of severity of stress on whole-body protein kinetics in surgical patients receiving parenteral nutrition.Nutrition19961211-1276376510.1016/S0899‑9007(96)00214‑6 8974101
     [Google Scholar]
  20. AntounS. ReyA. BéalJ. MontangeF. PressoirM. VassonM.P. DupoironD. Gourdiat-BoryeA. GuillaumeA. MagetB. NitenbergG. RaynardB. BachmannP. Nutritional risk factors in planned oncologic surgery: What clinical and biological parameters should be routinely used?World J. Surg.20093381633164010.1007/s00268‑009‑0033‑3 19387725
     [Google Scholar]
  21. YasudaK. TaharaK. KumeM. TsutsuiS. HigashiH. Kitano, S. Risk factors for morbidity and mortality following abdominal surgery in patients on maintenance hemodialysis.Hepatogastroenterology2007548022822284 18265648
     [Google Scholar]
  22. YuanX.Y. HeC.L. ZhangC.H. The role of exogenous albumin supplementation in early hypoalbuminemia after gastrointestinal surgery: A prospective randomized controlled study.J. Gastrointest. Oncol.2008101
     [Google Scholar]
  23. WeiX. PanY. LiX.Y. Effect of perioperative application of albumin on postoperative complications of colorectal cancer without preoperative hypoproteinemia.Guangxi Medicine2018401111781181
     [Google Scholar]
  24. HorowitzF.B. ReadR.L. PowellL.L. A retrospective analysis of 25% human serum albumin supplementation in hypoalbuminemic dogs with septic peritonitis.Can. Vet. J.2015566591597 26028681
     [Google Scholar]
  25. DuboisM.J. Orellana-JimenezC. MelotC. De BackerD. BerreJ. LeemanM. BrimioulleS. AppoloniO. CreteurJ. VincentJ.L. Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study.Crit. Care Med.200634102536254010.1097/01.CCM.0000239119.57544.0C 16915107
     [Google Scholar]
  26. ArendsJ. BodokyG. BozzettiF. FearonK. MuscaritoliM. SelgaG. van Bokhorst-de van der Schueren, M.A.E.; von Meyenfeldt, M.; Zürcher, G.; Fietkau, R.; Aulbert, E.; Frick, B.; Holm, M.; Kneba, M.; Mestrom, H.J.; Zander, A. ESPEN guidelines on enteral nutrition: Non-surgical oncology.Clin. Nutr.200625224525910.1016/j.clnu.2006.01.020 16697500
     [Google Scholar]
  27. FujiiT. SutohT. MoritaH. KatohT. YajimaR. TsutsumiS. AsaoT. KuwanoH. Serum albumin is superior to prealbumin for predicting short-term recurrence in patients with operable colorectal cancer.Nutr. Cancer20126481169117310.1080/01635581.2012.718034 23163845
     [Google Scholar]
  28. LinJ.X. ChenX.W. ChenZ.H. HuangX.Y. YangJ.J. XingY.F. YinL.H. LiX. WuX.Y. A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy.Medicine20179626e737310.1097/MD.0000000000007373 28658162
     [Google Scholar]
  29. SmeetsH.J. KievitJ. DulferF.T. HermansJ. MoolenaarA.J. Analysis of post-operative hypalbuminaemia: A clinical study.Int. Surg.1994792152157 7928151
     [Google Scholar]
  30. GaoX.M. Relationship between perioperative M-POSSUM scores and changes in plasma albumin levels in general surgery patients with moderate and severe surgical stress. Doctoral dissertation, Qingdao University,2009
     [Google Scholar]
  31. Torres-RosasR. YehiaG. PeñaG. MishraP. del Rocio Thompson-BonillaM. Moreno-EutimioM.A. Arriaga-PizanoL.A. IsibasiA. UlloaL. Dopamine mediates vagal modulation of the immune system by electroacupuncture.Nat. Med.201420329129510.1038/nm.3479 24562381
     [Google Scholar]
  32. KinrossJ.M. AlkhamesiN. BartonR.H. SilkD.B. YapI.K.S. DarziA.W. HolmesE. NicholsonJ.K. Global metabolic phenotyping in an experimental laparotomy model of surgical trauma.J. Proteome Res.201110127728710.1021/pr1003278 21105667
     [Google Scholar]
  33. ChiY.L. ZhangW.L. YangF. SuF. ZhouY.K. Transcutaneous electrical acupoint stimulation for improving postoperative recovery, reducing stress and inflammatory responses in elderly patient undergoing knee surgery.Am. J. Chin. Med.20194771445145810.1142/S0192415X19500745 31752522
     [Google Scholar]
  34. ChenY.P. XuP.Y. Research progress on early diagnosis and prevention measures of intestinal barrier dysfunction in patients undergoing major abdominal surgery.J. Gastroenterol. Hepatol.20192807830834
     [Google Scholar]
  35. GengY. DongC. JunL. Effect of electroacupuncture at the foot-sanli point on intestinal mucosal barrier repair after ischemia-reperfusion injury in the rat small intestine. Chin. Tradi. Chinese.Med. Emerg.2016250713001302
     [Google Scholar]
  36. HuangM.S. LiuD.J. Clinical study on the protection of intestinal mucosal barrier damage during TPN after gastrointestinal tumor surgery by acupuncture.Chin. J. Cancer Res.2002914041
     [Google Scholar]
  37. ZhangL.L. FangJ.Q. ShaoX.M. Analysis of the hepatoprotective effect of TEAS combination drug in general anesthesia with controlled hypotension to 60% of basal MAP level.J. Tradit. Chin. Med.2012301021672171
     [Google Scholar]
  38. ShaoX.M. FangJ.Q. ZhangL.L. Effects of controlled hypotension to different levels of hepatic blood flow by transcutaneous electrical stimulation of acupuncture points combined with pharmacological general anesthesia.Chin. J. Integr. Med.2012326785788
     [Google Scholar]
  39. ZhengX. MengJ. FangQ. Electroacupuncture reduces the dose of midazolam monitored by the bispectral index in critically ill patients with mechanical ventilation: An exploratory study.Acupunct. Med.2012302788410.1136/acupmed‑2011‑010095 22459647
     [Google Scholar]
  40. ShaL. KongX.C. XieX.F. Effect of needle-drug combination anesthesia on organ function in patients undergoing laparoscopic cholecystectomy.Shanghai J. Acupunct. Moxibustion20153410938940
     [Google Scholar]
  41. BjellandI. DahlA.A. HaugT.T. NeckelmannD. The validity of the hospital anxiety and depression scale. an updated literature review.J. Psychosom. Res.2002522697710.1016/S0022‑3999(01)00296‑3 11832252
     [Google Scholar]
  42. WallströmÅ. FrismanG.H. Facilitating early recovery of bowel motility after colorectal surgery: A systematic review.J. Clin. Nurs.2014231-2244410.1111/jocn.12258 23786567
     [Google Scholar]
  43. ShinK.M. ParkJ.E. LeeS. ChoiS.M. AhnY.C. LeeJ.W. KimJ.H. SonC.G. Effect of siguan acupuncture on gastrointestinal motility: A randomized, sham-controlled, crossover trial.Evid. Based Complement. Alternat. Med.201320131710.1155/2013/918392 23762166
     [Google Scholar]
  44. NgS.S.M. LeungW.W. MakT.W.C. HonS.S.F. LiJ.C.M. WongC.Y.N. TsoiK.K.F. LeeJ.F.Y. Electroacupuncture reduces duration of postoperative ileus after laparoscopic surgery for colorectal cancer.Gastroenterology20131442307313.e110.1053/j.gastro.2012.10.050 23142625
     [Google Scholar]
  45. YangZ.K. WuM.L. XinJ.J. HeW. SuY.S. ShiH. WangX.Y. HuL. JingX.H. LitscherG. Manual acupuncture and laser acupuncture for autonomic regulations in rats: observation on heart rate variability and gastric motility.Evid. Based Complement. Alternat. Med.201320131710.1155/2013/276320 24348694
     [Google Scholar]
  46. ChenJ.D.Z. NiM. YinJ. Electroacupuncture treatments for gut motility disorders.Neurogastroenterol. Motil.2018307e1339310.1111/nmo.13393 29906324
     [Google Scholar]
  47. LiangC. WangK.Y. GongM.R. LiQ. YuZ. XuB. Electro‐acupuncture at ST 37 and ST 25 induce different effects on colonic motility via the enteric nervous system by affecting excitatory and inhibitory neurons.Neurogastroenterol. Motil.2018307e1331810.1111/nmo.13318 29488287
     [Google Scholar]
  48. DengJ.J. Effect of acupuncture on the repair and regeneration of Cajal mesenchymal cells after colonic anastomosis.World J. Chin. Digest.2010363863386810.11569/wcjd.v18.i36.3863
     [Google Scholar]
  49. DengJ.J. YuanQ. Effect of acupuncture on the regulatory mechanism of contractile thick muscle filaments in gastrointestinal smooth muscle.Shanghai J. Acupunct. Moxibustion20113011783786
     [Google Scholar]
  50. JangJ.H. LeeD.J. BaeC.H. HaK.T. KwonS. ParkH.J. HahmD.H. LeeH. KimS. Changes in small intestinal motility and related hormones by acupuncture stimulation at Zusanli (ST 36) in mice.Chin. J. Integr. Med.201723321522010.1007/s11655‑016‑2609‑8 27586472
     [Google Scholar]
  51. YangX.Y. XiaoJ. ChenY.H. WangZ.T. WangH.L. HeD.H. ZhangJ. Dexamethasone alone vs in combination with transcutaneous electrical acupoint stimulation or tropisetron for prevention of postoperative nausea and vomiting in gynaecological patients undergoing laparoscopic surgery.Br. J. Anaesth.2015115688388910.1093/bja/aev352 26507494
     [Google Scholar]
  52. CheongK.B. ZhangJ. HuangY. ZhangZ. The effectiveness of acupuncture in prevention and treatment of postoperative nausea and vomiting--a systematic review and meta-analysis.PLoS One2013812e8247410.1371/journal.pone.0082474 24349293
     [Google Scholar]
  53. PanH. LiJ. ZhaoY. Effect of electro-acupuncture on gastrointestinal dysfunction after open-heart surgery with Foot San Li and Neiguan: A randomized controlled trial.Acupuncture Research.20164105457461 29071949
     [Google Scholar]
  54. ZhuZ.T. WuW.Z. ZhengM. Effect of electroacupuncture on gastrointestinal function in 30 patients undergoing laparoscopic cholecystectomy.Chinese Acupuncture.20214102131132
     [Google Scholar]
  55. YuB. DingL.L. BinL. Study on the effects of transcutaneous acupoint electrical stimulation on cerebral protection and stress in patients undergoing general anesthesia for laparoscopic surgery.Shaanxi Trad. Chin. Med.2020412241244
     [Google Scholar]
  56. HuS. ZhangL.J. BaiH.Y. Effects of electroacupuncture on tissue tumor necrosis factor and multiple organ function impairment in rats with sepsis.Chin. J. Pathol.20102602353356
     [Google Scholar]
  57. LiY.S. XuF. LiH.H. Protective effect of electroacupuncture stimulation on hepatic ischemia-reperfusion injury in rats at the foot-sanli point.Acad. J. Second Mil. Med. Univ.2011320219119410.3724/SP.J.1008.2011.00191
     [Google Scholar]
  58. YaoY. ZhaoQ. GongC. WuY. ChenY. QiuL. WuX. ChenY. Transcutaneous electrical acupoint stimulation improves the postoperative quality of recovery and analgesia after gynecological laparoscopic surgery: A randomized controlled trial.Evid. Based Complement. Alternat. Med.201520151610.1155/2015/324360 26170873
     [Google Scholar]
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Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Nutrition and Promotes Early Recovery of Gastrointestinal Function in Patients with Colorectal Cancer
Comb Chem High Throughput Screen 28, 64 (2025); https://doi.org/10.2174/0113862073255619231102112544
/content/journals/cchts/10.2174/0113862073255619231102112544
/content/journals/cchts/10.2174/0113862073255619231102112544
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  • Article Type:     Research Article
Keyword(s): albumin (ALB); colorectal cancer; nutrition; rapid recovery; total protein (TP); Transcutaneous electrical acupoint stimulation

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