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Volume 27, Issue 19
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Objective

The objective of this study is to assess the correlation between Piezo2 and tumors through a comprehensive meta-analysis and database validation.

Methods

Case-control studies investigating the association between Piezo2 and tumors were obtained from various databases, including China National Knowledge Infrastructure (CNKI), SinoMed, Embase, Web of Science, The Cochrane Library, and PubMed. The search was performed from the inception of each database up until May 2023. Two researchers independently screened the literature, extracted data, and assessed the quality of the included studies. Meta-analysis of the included literature was conducted using Stata 12.0 software. Additionally, the Gene Expression Profiling Interactive Analysis (GEPIA) database predicted a correlation between Piezo2 expression and prognostic value in tumor patients.

Results

A total of three studies, involving a combined sample size of 392 participants, were included in the meta-analysis. The findings revealed that the expression level of Piezo2 in tumor patients was not significantly associated with age, gender, or tumor size. However, it was found to be positively correlated with lymphatic invasion (OR = 7.89, 95%CI: 3.96-15.73) and negatively correlated with invasion depth (OR = 0.17, 95%CI: 0.06-0.47), TNM stage (OR = 0.48, 95%CI: 0.27-0.87), and histological grade (OR = 0.40, 95%CI: 0.21-0.77). Confirming these findings, the GEPIA database indicated that high expression of Piezo2 was associated with poor prognosis of disease-free survival in patients with colon adenocarcinoma (HR=1.6, = 0.049) and gastric cancer (HR=1.6, = 0.017).

Conclusion

Piezo2 may be associated with poor prognosis and clinicopathological parameters in tumor patients.

© 2024 Bentham Science Publishers
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2024-12-01
2024-11-22

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References

  1. StockerS.D. SvedA.F. AndresenM.C. Missing pieces of the Piezo1/Piezo2 baroreceptor hypothesis: An autonomic perspective.J. Neurophysiol.201912231207121210.1152/jn.00315.2019 31314636
     [Google Scholar]
  2. Del RosarioJ.S. YudinY. SuS. HartleC.M. MirshahiT. RohacsT. Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ.EMBO Rep.2020215e4912410.15252/embr.201949124 32227462
     [Google Scholar]
  3. SchneiderE.R. AndersonE.O. FeketaV.V. MastrottoM. NikolaevY.A. GrachevaE.O. BagriantsevS.N. A cross-species analysis reveals a general role for piezo2 in mechanosensory specialization of trigeminal ganglia from tactile specialist birds.Cell Rep.201926819791987.e310.1016/j.celrep.2019.01.100 30784581
     [Google Scholar]
  4. EtemE.Ö. CeylanG.G. ÖzaydınS. CeylanC. ÖzercanI. KuloğluT. The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma.Adv. Clin. Exp. Med.20182781025103110.17219/acem/71080 30010255
     [Google Scholar]
  5. YangH. LiuC. ZhouR.M. YaoJ. LiX.M. ShenY. ChengH. YuanJ. YanB. JiangQ. Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability.Oncotarget2016728446304464310.18632/oncotarget.10134 27329839
     [Google Scholar]
  6. LouW. LiuJ. DingB. JinL. XuL. LiX. ChenJ. FanW. Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer.Aging20191192628265210.18632/aging.101934 31058608
     [Google Scholar]
  7. HuangZ. SunZ. ZhangX. NiuK. WangY. ZhengJ. LiH. LiuY. Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.Biosci. Rep.2019393BSR2018167910.1042/BSR20181679 30745454
     [Google Scholar]
  8. ChenT. ZhangL.J. ZhangL.J. RongS.K. WangZ. PengG.Y. GongF.H. LiH. Expression and clinical significance of Piezo2 in colorectal cancer.J. Ningxia Med. Uni.20204201212410.16050/j.cnki.issn1674‑6309.2020.01.004
     [Google Scholar]
  9. ShangH. XuA. YanH. XuD. ZhangJ. FangX. PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.Adv. Clin. Exp. Med.202332776377610.17219/acem/157515 36753373
     [Google Scholar]
  10. LiangT. DaM.X. Expression and clinical significance of PIEZO2 in gastric cancer.Comb. Chem. High Throughput Screen.202326122194220010.2174/1386207326666230209140929 36757044
     [Google Scholar]
  11. HuttnerA. VerhaeghE.M. HarbarthS. MullerA.E. TheuretzbacherU. MoutonJ.W. Nitrofurantoin revisited: A systematic review and meta-analysis of controlled trials.J. Antimicrob. Chemother.20157092456246410.1093/jac/dkv147 26066581
     [Google Scholar]
  12. WiedermannC.J. Use of hyperoncotic human albumin solution in severe traumatic brain injury revisited—a narrative review and meta-analysis.J. Clin. Med.2022119266210.3390/jcm11092662 35566786
     [Google Scholar]
  13. LeeS.H. LeeO.S. KimS.T. LeeY.S. Revisiting arthroscopic partial meniscectomy for degenerative tears in knees with mild or no osteoarthritis.Clin. J. Sport Med.202030319520210.1097/JSM.0000000000000585 29995671
     [Google Scholar]
  14. TangZ. KangB. LiC. ChenT. ZhangZ. GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis.Nucleic Acids Res.201947W1W556W56010.1093/nar/gkz430 31114875
     [Google Scholar]
  15. DerSimonianR. LairdN. Meta-analysis in clinical trials revisited.Contemp. Clin. Trials201545Pt A13914510.1016/j.cct.2015.09.002
     [Google Scholar]
  16. ChengL. ShenZ. ZhouC. Promoter hypermethylation of PIEZO2 is a risk factor and potential clinical biomarker for laryngeal squamous cell carcinoma.Int. J. Clin. Exp. Pathol.201710121163511643 31966521
     [Google Scholar]
  17. ZhaoF. ZhangL. WeiM. DuanW. WuS. KasimV. Mechanosensitive ion channel piezo1 signaling in the hall-marks of cancer: structure and functions.Cancers20221419495510.3390/cancers14194955 36230880
     [Google Scholar]
  18. ZhuZ. LiW. GongM. WangL. YueY. QianW. ZhouC. DuanW. HanL. LiL. WuZ. MaQ. LinM. WangS. WangZ. Piezo1 act as a potential oncogene in pancreatic cancer progression.Life Sci.202231012103510.1016/j.lfs.2022.121035 36208662
     [Google Scholar]
  19. KimO.H. ChoiY.W. ParkJ.H. HongS.A. HongM. ChangI.H. LeeH.J. Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.Life Sci.202230812093610.1016/j.lfs.2022.120936 36084759
     [Google Scholar]
  20. MarshallK.L. SaadeD. GhitaniN. CoombsA.M. SzczotM. KellerJ. OgataT. DaouI. StowersL.T. BönnemannC.G. CheslerA.T. PatapoutianA. PIEZO2 in sensory neurons and urothelial cells coordinates urination.Nature2020588783729029510.1038/s41586‑020‑2830‑7 33057202
     [Google Scholar]
  21. MichelN. NarayananP. ShomroniO. SchmidtM. Maturational changes in mouse cutaneous touch and piezo2-mediated mechanotransduction.Cell Rep.202032310791210.1016/j.celrep.2020.107912 32697985
     [Google Scholar]
  22. PethőZ. NajderK. BulkE. SchwabA. Mechanosensitive ion channels push cancer progression.Cell Calcium201980799010.1016/j.ceca.2019.03.007 30991298
     [Google Scholar]
  23. FangX.Z. ZhouT. XuJ.Q. WangY.X. SunM.M. HeY.J. PanS.W. XiongW. PengZ.K. GaoX.H. ShangY. Structure, kinetic properties and biological function of mechanosensitive Piezo channels.Cell Biosci.20211111310.1186/s13578‑020‑00522‑z 33422128
     [Google Scholar]
  24. SavadipourA. NimsR.J. RashidiN. Garcia-CastorenaJ.M. TangR. MarushackG.K. OswaldS.J. LiedtkeW.B. GuilakF. Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.Proc. Natl. Acad. Sci.202312030e222195812010.1073/pnas.2221958120 37459546
     [Google Scholar]
  25. QiuX. DengZ. WangM. FengY. BiL. LiL. Piezo protein determines stem cell fate by transmitting mechanical signals.Hum. Cell202236254055310.1007/s13577‑022‑00853‑8 36580272
     [Google Scholar]
  26. TianS. CaiZ. SenP. van UdenD. van de KampE. ThuilletR. TuL. GuignabertC. BoomarsK. Van der HeidenK. BrandtM.M. MerkusD. Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.Am. J. Physiol. Heart Circ. Physiol.20223235H958H97410.1152/ajpheart.00220.2022 36149769
     [Google Scholar]
  27. YangK. HeX. WuZ. YinY. PanH. ZhaoX. SunT. The emerging roles of piezo1 channels in animal models of multiple sclerosis.Front. Immunol.20221397652210.3389/fimmu.2022.976522 36177027
     [Google Scholar]
  28. RadinI. RichardsonR.A. HaswellE.S. Moss PIEZO homologs have a conserved structure, are ubiquitously expressed, and do not affect general vacuole function.Plant Signal. Behav.2022171201589310.1080/15592324.2021.2015893 34951344
     [Google Scholar]
  29. BektasS. KaptanE. RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells.Mol. Biol. Rep.202249109257926610.1007/s11033‑022‑07759‑6 36057880
     [Google Scholar]
  30. YeX. XiaY. ZhengY. ChenW. ChenZ. ChengZ. WangB. The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism.Heliyon202289e1030110.1016/j.heliyon.2022.e10301 36097495
     [Google Scholar]
  31. WangY. MangX. LiD. ChenY. CaiZ. TanF. Piezoeletric cold atmospheric plasma induces apoptosis and autophagy in human hepatocellular carcinoma cells through blocking glycolysis and AKT/mTOR/HIF-1α pathway.Free Radic. Biol. Med.202320813415210.1016/j.freeradbiomed.2023.07.036 37543168
     [Google Scholar]
  32. QinX. NiZ. JiangJ. LiuX. DongX. LiM. MiaoK. RaoS. ZhangW. CaiK. High‐throughput membrane‐anchored proteome screening reveals PIEZO1 as a promising antibody‐drug target for human esophageal squamous cell carcinoma.Cancer Med.202211193700371310.1002/cam4.4744 35608274
     [Google Scholar]
  33. García-MesaY. Martín-SanzR. García-PiquerasJ. CoboR. Muñoz-BravoS. García-SuárezO. Martín-BiedmaB. VegaJ.A. FeitoJ. Merkel cell carcinoma display PIEZO2 immunoreactivity.J. Pers. Med.202212689410.3390/jpm12060894 35743679
     [Google Scholar]
  34. ShinK.C. ParkH.J. KimJ.G. LeeI.H. ChoH. ParkC. SungT.S. KohS.D. ParkS.W. BaeY.M. The Piezo2 ion channel is mechanically activated by low-threshold positive pressure.Sci. Rep.201991644610.1038/s41598‑019‑42492‑4 31015490
     [Google Scholar]
  35. NiK. ZhangW. NiY. MaoY.T. WangY. GuX.P. MaZ.L. Dorsal root ganglia NR2B mediated Epac1 Piezo2 signaling pathway contributes to mechanical allodynia of bone cancer pain.Oncol. Lett.202121433810.3892/ol.2021.12599 33692870
     [Google Scholar]
  36. SprowlsS.A. LathiaJ.D. Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability.Neuron202311113510.1016/j.neuron.2022.12.008 36603549
     [Google Scholar]
  37. ChenX. MominA. WanggouS. WangX. MinH.K. DouW. GongZ. ChanJ. DongW. FanJ.J. XiongY. TalipovaK. ZhaoH. ChenY.X. VeerasammyK. FeketeA. KumarS.A. LiuH. YangQ. SonJ.E. DouZ. HuM. PardisP. JuraschkaK. DonovanL.K. ZhangJ. RamaswamyV. SelvaduraiH.J. DirksP.B. TaylorM.D. WangL.Y. HuiC.C. AbzalimovR. HeY. SunY. LiX. HuangX. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.Neuron202311113048.e1410.1016/j.neuron.2022.10.007 36323321
     [Google Scholar]
  38. KatsutaE. TakabeK. VujcicM. GottliebP.A. DaiT. Mercado-PerezA. BeyderA. WangQ. OpyrchalM. Mechano-sensing channel PIEZO2 enhances invasive phenotype in triple-negative breast cancer.Int. J. Mol. Sci.20222317990910.3390/ijms23179909 36077309
     [Google Scholar]
  39. Pardo-PastorC. Rubio-MoscardoF. Vogel-GonzálezM. SerraS.A. AfthinosA. MrkonjicS. DestaingO. AbenzaJ.F. Fernández-FernándezJ.M. TrepatX. Albiges-RizoC. KonstantopoulosK. ValverdeM.A. Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.Proc. Natl. Acad. Sci.201811581925193010.1073/pnas.1718177115 29432180
     [Google Scholar]
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Prognosis and Clinical Significance of Piezo2 in Tumor: A Meta-analysis and Database Validation
Comb Chem High Throughput Screen 27, 2912 (2024); https://doi.org/10.2174/0113862073251440231025111358
/content/journals/cchts/10.2174/0113862073251440231025111358
/content/journals/cchts/10.2174/0113862073251440231025111358
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  • Article Type:     Research Article
Keyword(s): bioinformatics analysis; gastric cancer; GEPIA; Piezo2; prognosis; tumor

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