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- Volume 23, Issue 9, 2023
Current Cancer Drug Targets - Volume 23, Issue 9, 2023
Volume 23, Issue 9, 2023
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mRNA Vaccine - A New Cancer Treatment Strategy
Authors: Tian Tan, Shu-Ting Deng, Bing-Huo Wu, Qi Yang, Meng-Wan Wu, Hong Wu, Chen-Hui Cao and Chuan XuThe corresponding mRNA vaccines Comirnaty (BNT162b2) and Spikevax (mRNA-1273) have been authorized for emergency use since the COVID-19 outbreak. Most clinical researches have also discovered that the mRNA vaccine is a revolutionary strategy for preventing and treating numerous diseases, including cancers. Unlike viral vectors or DNA vaccines, mRNA vaccines cause the body to directly produce proteins following i Read More
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Therapeutic Potential of Clostridium novyi-NT in Cancer: Current Knowledge and Future Perspectives
Resistance to conventional antitumour therapies and Hypoxia in patients with advanced solid tumours are two major reasons for the failure of conventional anti-tumour therapies. Therefore, it is important to find a new therapeutic method that can overcome these problems. An attenuated anaerobic bacterium, Clostridium novyi-NT, could target Hypoxic and Necrotic areas of tumours causing tumour lysis and stimulating a h Read More
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Overcoming the Limitations of Therapeutic Strategies to Combat Pancreatic Cancer using Nanotechnology
Authors: Shivang Dhoundiyal and Md. A. AlamThere is a significant unmet demand for the treatment of pancreatic cancer. Many patients do not make it to past five years after diagnosis. The effectiveness of treatment varies greatly from patient to patient, and many people are too weak to endure chemotherapy or surgery. Unfortunately, by the time patients receive the diagnosis, the tumour typically spreads, rendering these chemotherapies ineffective. Effe Read More
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Second-line Endocrine Therapy of Hormone Receptor-positive/HER2- negative Advanced Breast Cancer: A Systematic Review and Network Meta-analysis
Authors: Tianzhuo Wang, Guoshuang Shen, Jinming Li, Xingfa Huo, Miaozhou Wang, Zhen Liu, Fuxing Zhao, Dengfeng Ren and Jiuda ZhaoBackground: The optimal second-line therapy for hormone receptor-positive (HR+)/ human epidermal growth factor receptor 2 negative (HER2−) advanced or metastatic breast cancer is yet to be established. Therefore, we conducted a network meta-analysis (NMA) of marketed drugs to compare their efficacy. Methods: We searched the literature in PubMed, Embase, Web of Science databases, and the main international Read More
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Dihydrotanshinone I Inhibits Pancreatic Cancer Progression via Hedgehog/ Gli Signal Pathway
Authors: Wenqian Huang, Yile Dai, Liming Xu, Yefan Mao, Zhengwei Huang and Xiaoke JiIntroduction: Pancreatic cancer is highly fatal and its incidence is rising worldwide. Its poor prognosis is attributed to a lack of effective diagnostic and therapeutic strategies. Dihydrotanshinone I (DHT), a phenanthrene quinone liposoluble compound from Salvia miltiorrhiza Bunge (Danshen), exerts anti-tumor effects by inhibiting cell proliferation, enhancing apoptosis, and inducing cell differentiation. However, its effects on pa Read More
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HDAC4-mediated Deacetylation of Glutaminase Facilitates Glioma Stemness
Authors: Gang Xu, Jianqiang Qu and Ming ZhangBackground: Inhibiting cancer metabolism via glutaminase (GLS) is a promising strategy to disrupt tumor progression. However, the mechanism regarding GLS acetylation remains largely unknown. Methods: Mitochondrial protein isolation and glutaminase activity assay were used to examine GLS activity. RT-qPCR, western blot, sphere-formation, ALDH activity, and tumor-initiating assays were performed to evaluate the alterati Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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