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Volume 25, Issue 1
  • ISSN: 1568-0096
  • E-ISSN: 1873-5576

Abstract

It is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as and Many periodontopathic micro-organisms, like sp., sp., sp., sp., , and strongly have an impact on the development of oral cancers. Three basic mechanisms are involved in pathogen-mediated cancer development, like chronic inflammation-mediated angiogenesis, inhibition of cellular apoptosis, and release of carcinogenic by-products. Microbiota has a dichotomous role to play in cancer, microbiota can be used for cancer management too. Shreds of evidence are there to support the fact that microbiota enhances the chemotherapeutic drug efficacy. This review presents the possible mechanism of the oncogenic effect of microbiota with emphasis on the oral microbiome and also attempts to explain the intricate role of microbiota in cancer management.

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2024-02-21
2024-11-23

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/content/journals/ccdt/10.2174/0115680096282503240124104029
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An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
Curr. Cancer Drug Targets< 25, 38 (2025); https://doi.org/10.2174/0115680096282503240124104029
/content/journals/ccdt/10.2174/0115680096282503240124104029
/content/journals/ccdt/10.2174/0115680096282503240124104029
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  • Article Type:     Review Article
Keyword(s): angiogenesis; cellular apoptosis; chemotherapeutic drug efficacy; colorectal cancer; dysbiosis; Oral microbiota; oral squamous cell carcinoma

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