Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Cancer Drug Targets
  4. Volume 25, Issue 1
  5. Article
Volume 25, Issue 1
  • ISSN: 1568-0096
  • E-ISSN: 1873-5576

Abstract

Background

Thyroid metastasis arising from primary breast cancer is a rare phenomenon, with only a handful of cases documented in both national and international literature. The management approach and prognosis of this occurrence have sparked debates and uncertainties.

Case Presentation

Herein, we report the case of a 55-year-old woman with breast cancer. She previously underwent extensive excision of the breast lesion with adjuvant chemotherapy and endocrine therapy. After 9 years, she presented with neck discomfort and examination suggested right thyroid metastasis and lymph node metastasis in the neck. Imaging showed pulmonary and bone metastases. Furthermore, the patient received endocrine therapy. After 7 months of follow-up, the patient survived without any new distant metastases. Thyroid metastases originating from breast cancer often unfold with a subtle, intricate nature, making early detection challenging. They tend to emerge inconspicuously, intertwining with widespread systemic metastases, hinting at a less favorable prognosis.

Conclusion

Given the unusual clinical indicators, identifying heterochronic thyroid metastases in patients with tumors poses a distinct challenge, requiring clinicians to navigate the follow-up process with heightened sensitivity. The key lies in timely detection and early intervention, factors that can significantly enhance the overall quality of life for patients.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/ccdt/10.2174/0115680096274465240129055950
2024-02-22
2024-12-03

  • From This Site

    /content/journals/ccdt/10.2174/0115680096274465240129055950
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. SungH. FerlayJ. SiegelR.L. LaversanneM. SoerjomataramI. JemalA. BrayF. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.202171320924910.3322/caac.2166033538338
     [Google Scholar]
  2. WuQ. LiJ. ZhuS. WuJ. ChenC. LiuQ. WeiW. ZhangY. SunS. Breast cancer subtypes predict the preferential site of distant metastases: A SEER based study.Oncotarget2017817279902799610.18632/oncotarget.1585628427196
     [Google Scholar]
  3. ChungA.Y. TranT.B. BrumundK.T. WeismanR.A. BouvetM. Metastases to the thyroid: A review of the literature from the last decade.Thyroid201222325826810.1089/thy.2010.015422313412
     [Google Scholar]
  4. HegerovaL. GriebelerM.L. ReynoldsJ.P. HenryM.R. GharibH. Metastasis to the thyroid gland.Am. J. Clin. Oncol.201538433834210.1097/COC.0b013e31829d1d0923799287
     [Google Scholar]
  5. RaveendrannairA. MathewsA. VargheseB. JayasreeK. Papillary carcinoma thyroid serving as recipient tumor to carcinoma breast: A rare example of tumor-to-tumor metastasis.Indian J. Pathol. Microbiol.201962112212410.4103/IJPM.IJPM_672_1730706875
     [Google Scholar]
  6. ZhouL. ChenL. XuD. ShaoQ. GuoZ. GeM. Breast cancer metastasis to thyroid: A retrospective analysis.Afr. Health Sci.20181741035104310.4314/ahs.v17i4.1129937874
     [Google Scholar]
  7. GhosseinC.A. KhimrajA. DoganS. XuB. Metastasis to the thyroid gland: A single-institution 16-year experience.Histopathology202178450851910.1111/his.1424632897542
     [Google Scholar]
  8. SchmidK.W. Lymph node and distant metastases of thyroid gland cancer.Pathologe201536S2Suppl. 217117510.1007/s00292‑015‑0071‑626357953
     [Google Scholar]
  9. CordesM. KuwertT. Metastases of non-thyroidal tumors to the thyroid gland: A regional survey in middle franconia.Exp. Clin. Endocrinol. Diabetes2014122527327610.1055/s‑0034‑137262324839221
     [Google Scholar]
  10. MistelouA. PapadatosS.S. KousiC. LampriE. MitsisM. VougiouklakisT. GalaniV. Thyroid gland as a target of secondary malignancies - an autopsy study and review data.Folia Med.201961227728810.2478/folmed‑2018‑007731301659
     [Google Scholar]
  11. BesicN. GazicB. Sites of metastases of anaplastic thyroid carcinoma: autopsy findings in 45 cases from a single institution.Thyroid201323670971310.1089/thy.2012.025223148580
     [Google Scholar]
  12. DurmoR. AlbanoD. GiubbiniR. Thyroid metastasis from breast cancer detected by 18F-FDG PET/CT.Endocrine201964242442510.1007/s12020‑019‑01916‑x30937721
     [Google Scholar]
  13. FalconeR. RamundoV. LamartinaL. AscoliV. BoscoD. Di GioiaC. MontesanoT. BiffoniM. BononiM. GiacomelliL. MinniA. SegniM. MaranghiM. CantisaniV. DuranteC. GraniG. Sonographic presentation of metastases to the thyroid gland: A case series.J. Endocr. Soc.20182885585910.1210/js.2018‑0012430019024
     [Google Scholar]
  14. JungH.K. KimB. RyuJ.H. Intrathyroid metastasis of breast cancer: Sonographic findings.J. Clin. Ultrasound202149548849110.1002/jcu.2294933247600
     [Google Scholar]
  15. YangS.I. ParkK.K. KimJ.H. Thyroid metastasis from breast carcinoma accompanied by papillary thyroid carcinoma.Case Rep. Oncol.20147252853310.1159/00036574825232322
     [Google Scholar]
  16. EgañaN. SociasC. MatteucciT. BilbaoI. Alvarez-CocaM. Metástasis tiroidea de carcinoma lobulillar de mama.Endocrinol. Nutr.201259321922010.1016/j.endonu.2011.09.00922138624
     [Google Scholar]
  17. GoldfarbM. FreyerD.R. Comparison of secondary and primary thyroid cancer in adolescents and young adults.Cancer201412081155116110.1002/cncr.2846324615715
     [Google Scholar]
  18. StasiakM. MichalakR. LewinskiA. Thyroid primary and metastatic malignant tumours of poor prognosis may mimic subacute thyroiditis - time to change the diagnostic criteria: case reports and a review of the literature.BMC Endocr. Disord.20191918610.1186/s12902‑019‑0415‑y31387553
     [Google Scholar]
  19. IvyH.K. Cancer metastatic to the thyroid: A diagnostic problem.Mayo Clin. Proc.19845911-1285685910.1016/S0025‑6196(12)65622‑56503368
     [Google Scholar]
  20. ShimaokaK. SokalJ.E. PickrenJ.W. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings.Cancer196215355756510.1002/1097‑0142(196205/06)15:3<557::AID‑CNCR2820150315>3.0.CO;2‑H13911946
     [Google Scholar]
  21. WychuisA.R. BeahrsO.H. WoolnerL.B. Metastasis of carcinoma to the thyroid gland.Ann. Surg.1964160216917710.1097/00000658‑196408000‑0000114209716
     [Google Scholar]
  22. Harcourt-WebsterJ.N. Secondary neoplasm of the thyroid presenting as a goitre.J. Clin. Pathol.196518328228710.1136/jcp.18.3.28214304237
     [Google Scholar]
  23. PillayS.P. AngornI.B. BakerL.W. Tumour metastasis to the thyroid gland.S. Afr. Med. J.19775115509512854830
     [Google Scholar]
  24. NakhjavaniM.K. GharibH. GoellnerJ.R. HeerdenJ.A. Metastasis to the thyroid gland.Cancer199779357457810.1002/(SICI)1097‑0142(19970201)79:3<574::AID‑CNCR21>3.0.CO;2‑#9028370
     [Google Scholar]
  25. ChungS.Y. KimE.K. KimJ.H. OhK.K. KimD.J. LeeY.H. AnH.J. KimJ.S. Sonographic findings of metastatic disease to the thyroid.Yonsei Med. J.200142441141710.3349/ymj.2001.42.4.41111519083
     [Google Scholar]
  26. De RidderM. SermeusA.B.L. UrbainD. StormeG.A. Metastases to the thyroid gland—a report of six cases.Eur. J. Intern. Med.200314637737910.1016/S0953‑6205(03)90005‑714769497
     [Google Scholar]
  27. LooC.K.C. BurchettI.J. Fine needle aspiration biopsy of neuroendocrine breast carcinoma metastatic to the thyroid. A case report.Acta Cytol.2003471838710.1159/00032648012585036
     [Google Scholar]
  28. WoodK. ViniL. HarmerC. Metastases to the thyroid gland: The royal marsden experience.Eur. J. Surg. Oncol.200430658358810.1016/j.ejso.2004.03.01215256229
     [Google Scholar]
  29. OwensC.L. BasariaS. NicolT.L. Metastatic breast carcinoma involving the thyroid gland diagnosed by fine-needle aspiration: A case report.Diagn. Cytopathol.200533211011510.1002/dc.2031116007653
     [Google Scholar]
  30. KimT.Y. KimW.B. GongG. HongS.J. ShongY.K. Metastasis to the thyroid diagnosed by fine-needle aspiration biopsy.Clin. Endocrinol.200562223624110.1111/j.1365‑2265.2005.02206.x15670202
     [Google Scholar]
  31. GergesA.S. ShehataS.R. GoudaI.A. Metastasis to the thyroid gland; unusual site of metastasis.J. Egypt. Natl. Canc. Inst.2006181677217237852
     [Google Scholar]
  32. CichońS. AnielskiR. KonturekA. BarczyńskiM. CichońW. Metastases to the thyroid gland: Seventeen cases operated on in a single clinical center.Langenbecks Arch. Surg.2006391658158710.1007/s00423‑006‑0081‑116983577
     [Google Scholar]
  33. Molina GarridoM.J. PonceC.G. EscalanteS.M. Martínez y SevilaC. MenaA.C. Dysphagia and dysphonia in a woman with a previous breast cancer.Clin. Transl. Oncol.20068753353510.1007/s12094‑006‑0054‑416870543
     [Google Scholar]
  34. PapiG. FaddaG. CorselloS.M. CorradoS. RossiE.D. RadighieriE. MiragliaA. CaraniC. PontecorviA. Metastases to the thyroid gland: Prevalence, clinicopathological aspects and prognosis: A 10-year experience.Clin. Endocrinol.200766456557110.1111/j.1365‑2265.2007.02773.x17371476
     [Google Scholar]
  35. SaberA. RamzyS. GoudaI. Metastasis to the thyroid gland; unusual site of metastasis.Gulf J. Oncolog.200711515720084714
     [Google Scholar]
  36. CalzolariF. SartoriP.V. TalaricoC. ParmeggianiD. BerettaE. PezzulloL. BovoG. SperlonganoP. MonacelliM. LucchiniR. MissoC. GurradoA. D’AjelloM. UggeriF. PuxedduE. NasiP. TestiniM. RosatoL. BarbarisioA. AveniaN. Surgical treatment of intrathyroid metastases: Preliminary results of a multicentric study.Anticancer Res.2008285B2885288819031929
     [Google Scholar]
  37. MangJianbo MaiPeicheng XuNan Bilateral thyroid metastasis from breast cancer: A case report.Journal of modern oncology20101881644164510.3969/j.issn.1672‑4992.2010.08.71
     [Google Scholar]
  38. Skowrońska-JóźwiakE. Krawczyk-RusieckaK. AdamczewskiZ. SpornyS. ZadrożnyM. DedecjusM. BrzezińskiJ. LewińskiA. Metastases of breast cancer to the thyroid gland in two patients: A case report.Endokrynol. Pol.201061551251521049468
     [Google Scholar]
  39. IshikawaM. HiranoS. TsujiT. ItoJ. Management of metastasis to the thyroid gland.Auris Nasus Larynx201138342643010.1016/j.anl.2010.11.00921239125
     [Google Scholar]
  40. CihanY.B. DenizK. YilmazM.S. Synchronous parotid and thyroid gland metastases from breast cancer.Breast Care20116213313510.1159/00032750821673825
     [Google Scholar]
  41. RomeroI. MoraH. OsórioF. CostaS. CruzC. DamascenoM. AmendoeiraI. FougoJ-L. Breast cancer metastasis in thyroid gland - report of three cases.Breast201120S40S4110.1016/j.breast.2011.08.084
     [Google Scholar]
  42. WenQ. YinH. YinF. Thyroid metastases from breast cancer: Case report.Chin J Med Imaging Technol.201228917311732
     [Google Scholar]
  43. DingFeng Thyroid metastasis from breast cancer 3 case.Chin J Curr Adv Gen Surg2012152167168
     [Google Scholar]
  44. KolarevićD. TomasevićZ. MarkovićI. ZegaracM. PupićG. Rare localisation of breast cancer metastasis to thyroid gland.Vojnosanit. Pregl.201269121106110810.2298/VSP1212106K23424967
     [Google Scholar]
  45. WangW. A case of thyroid metastasis from occult breast cancer and review of the literature.Mil Med J S Chin201226660961010.13730/j.1009‑2595.2012.06.017
     [Google Scholar]
  46. YangM. WangW. ZhangC. Thyroid gland metastasis arising from breast cancer: A case report.Oncol. Lett.2013561836183810.3892/ol.2013.128723833651
     [Google Scholar]
  47. LiN. FaqinLv. WangZ. LiQ. TangW. Ultrasound manifestations of thyroid metastasis from breast carcinoma: Case report.Chin J Med Imaging Technol2014302268269
     [Google Scholar]
  48. BenbrahimW. GuerfiS. AyachiS. HachaniK. BenlalouiA. AmmariA. Intrathyroid metastasis to the breast cancer.Pan Arab Journal of Oncology.2016922323
     [Google Scholar]
  49. MagersM.J. DueberJ.C. LewM. PangJ.C. DavenportR.D. Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features.Diagn. Cytopathol.201644653053410.1002/dc.2346226932153
     [Google Scholar]
  50. PlonczakA.M. DiMarcoA.N. DinaR. GujralD.M. PalazzoF.F. Breast cancer metastases to the thyroid gland: An uncommon sentinel for diffuse metastatic disease: a case report and review of the literature.J. Med. Case Reports201711126910.1186/s13256‑017‑1441‑x28934992
     [Google Scholar]
  51. ZhouL. ChenL. XuD. ShaoQ. GuoZ. GeM. Breast cancer metastasis to thyroid: A retrospective analysis.African Health Sciences20171741035104310.4314/ahs.v17i4.11
     [Google Scholar]
  52. ZhangC. TianJ. LiuQ. WuC. Ultrasonographic and pathological findings of thyroid metastasis in invasive breast cancer: A case report.Chin J Med Ultrasound2018157557558[Electronic Edition].10.3877/cma.j.issn.1672‑6448.2018.07.017
     [Google Scholar]
  53. ZhouWeidong WangGuimin JinMeishan SunCui SuChang A case of thyroid metastasis misdiagnosed as thyroid carcinoma in breast cancer.Journal of north sichuan medical college201833227627710.3969/j.issn.1005‑3697.2018.02.036
     [Google Scholar]
  54. PensabeneM. StanzioneB. CerilloI. CianciaG. CozzolinoI. RuoccoR. CondelloC. Di LorenzoG. GiulianoM. ForestieriV. ArpinoG. De PlacidoS. LauriaR. It is no longer the time to disregard thyroid metastases from breast cancer: A case report and review of the literature.BMC Cancer201818114610.1186/s12885‑018‑4054‑x29409458
     [Google Scholar]
  55. InićZ. MartinovićA. InićM. PilčevićD. PupićG. Thyroid gland metastasis from breast cancer: A rare case report and literature overview.Srp. Arh. Celok. Lek.20181467-846646910.2298/SARH170504143I
     [Google Scholar]
  56. ChenHanhan ShiGuangxi ZhuQing SunZiyuan Bilateral thyroid metastasis from breast cancer: A case report and literature review.Chinese Journal of Clinical Research201932811381139
     [Google Scholar]
  57. SongC. MengY. ShangP. NanR. JiaZ. LiX. Bilateral thyroid metastasis from breast cancer: A case report and literature review.Chin J Metastatic Cancer.201921474810.3760/cma.j.issn.2096‑5400.2019.01.010
     [Google Scholar]
  58. WangM. LiuX. WeiB. LiuN. LiQ. SuX. Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine-needle aspiration cytology.Diagn. Cytopathol.202048547547810.1002/dc.2439632065477
     [Google Scholar]
  59. ZhangY.Y. XueS. WangZ.M. JinM.S. ChenZ.P. ChenG. ZhangQ. Thyroid metastasis from breast cancer presenting with enlarged lateral cervical lymph nodes: A case report.World J. Clin. Cases20208483884710.12998/wjcc.v8.i4.83832149069
     [Google Scholar]
  60. WangY. ZhouS. YuB. ZhouP. ZhuJ. WeiT. LiZ. Case report and review of literature: Thyroid metastases from breast carcinoma.Front. Endocrinol.20211263189410.3389/fendo.2021.63189433776925
     [Google Scholar]
  61. KiziltanG. BozdoganN. OzaslanC. Breast cancer metastasis into thyroid papillary carcinoma: A case report.Breast J.202127654754910.1111/tbj.1421933751701
     [Google Scholar]
  62. WenW. JiangH. WenH.Y. PengY.L. Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature.World J. Clin. Cases20221031106111510.12998/wjcc.v10.i3.110635127926
     [Google Scholar]
  63. HuangN. ChenX. WeiW. MoM. ChenJ. MaB. YangS. XuW. WuJ. JiQ. GuoX. LiuG. ShaoZ. WangY. Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer.Cancer Med.20187126393640010.1002/cam4.185630480382
     [Google Scholar]
  64. NguyenM. HeG. LamA.K. An update on the current epidemiological status of metastatic neoplasms to the thyroid.Cancer Epidemiol.20227910219210.1016/j.canep.2022.10219235653937
     [Google Scholar]
  65. JosephK.R. EdirimanneS. EslickG.D. The association between breast cancer and thyroid cancer: A meta-analysis.Breast Cancer Res. Treat.2015152117318110.1007/s10549‑015‑3456‑626058757
     [Google Scholar]
  66. BolfE.L. SpragueB.L. CarrF.E. A linkage between thyroid and breast cancer: A common etiology?Cancer Epidemiol. Biomarkers Prev.201928464364910.1158/1055‑9965.EPI‑18‑087730541751
     [Google Scholar]
  67. NielsenS.M. WhiteM.G. HongS. Aschebrook-KilfoyB. KaplanE.L. AngelosP. KulkarniS.A. OlopadeO.I. GroganR.H. The breast–thyroid cancer link: A systematic review and meta-analysis.Cancer Epidemiol. Biomarkers Prev.201625223123810.1158/1055‑9965.EPI‑15‑083326908594
     [Google Scholar]
  68. MahdiH. MesterJ.L. NizialekE.A. NgeowJ. MichenerC. EngC. Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: An international, multicenter, prospective study.Cancer2015121568869610.1002/cncr.2910625376524
     [Google Scholar]
  69. NiY. EngC. Vitamin E protects against lipid peroxidation and rescues tumorigenic phenotypes in cowden/cowden-like patient-derived lymphoblast cells with germline SDHx variants.Clin. Cancer Res.201218184954496110.1158/1078‑0432.CCR‑12‑105522829200
     [Google Scholar]
  70. BennettK.L. MesterJ. EngC. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.JAMA2010304242724273110.1001/jama.2010.187721177507
     [Google Scholar]
  71. LiS. YangJ. ShenY. ZhaoX. ZhangL. WangB. LiP. WangY. YiM. YangJ. Clinicopathological features, survival and risk in breast cancer survivors with thyroid cancer: An analysis of the SEER database.BMC Public Health2019191159210.1186/s12889‑019‑7947‑y31783815
     [Google Scholar]
  72. LalG. GroffM. HoweJ.R. WeigelR.J. SuggS.L. LynchC.F. Risk of subsequent primary thyroid cancer after another malignancy: latency trends in a population-based study.Ann. Surg. Oncol.20121961887189610.1245/s10434‑011‑2193‑222227921
     [Google Scholar]
  73. DongL. LuJ. ZhaoB. WangW. ZhaoY. Review of the possible association between thyroid and breast carcinoma.World J. Surg. Oncol.201816113010.1186/s12957‑018‑1436‑029976206
     [Google Scholar]
  74. YuanS. KarS. VithayathilM. CarterP. MasonA.M. BurgessS. LarssonS.C. Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer: A two-sample Mendelian randomization study.Int. J. Cancer202014771895190310.1002/ijc.3298832215913
     [Google Scholar]
  75. ConsortiF. Di TannaG. MilazzoF. AntonaciA. Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer.World J. Surg. Oncol.2011918810.1186/1477‑7819‑9‑8821835042
     [Google Scholar]
  76. WangX. ZengM. JuX. LinA. ZhouC. ShenJ. LiuZ. TangB. ChengQ. WangY. ZhangJ. LuoP. Correlation between second and first primary cancer: Systematic review and meta-analysis of 9 million cancer patients.Br. J. Surg.20241111znad37710.1093/bjs/znad37738055899
     [Google Scholar]
  77. BolfE.L. GillisN.E. BarnumM.S. BeaudetC.M. YuG.Y. TomczakJ.A. SteinJ.L. LianJ.B. SteinG.S. CarrF.E. The thyroid hormone receptor-RUNX2 axis: A novel tumor suppressive pathway in breast cancer.Horm. Cancer2020111344110.1007/s12672‑019‑00373‑231865591
     [Google Scholar]
  78. HüserS. GuthS. JoostH.G. SoukupS.T. KöhrleJ. KreienbrockL. DielP. LachenmeierD.W. EisenbrandG. VollmerG. NöthlingsU. MarkoD. MallyA. GruneT. LehmannL. SteinbergP. KullingS.E. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: A comprehensive safety evaluation.Arch. Toxicol.20189292703274810.1007/s00204‑018‑2279‑830132047
     [Google Scholar]
  79. Van FossenV.L. WilhelmS.M. EatonJ.L. McHenryC.R. Association of thyroid, breast and renal cell cancer: A population-based study of the prevalence of second malignancies.Ann. Surg. Oncol.20132041341134710.1245/s10434‑012‑2718‑323263698
     [Google Scholar]
  80. SchellongG. RiepenhausenM. EhlertK. BrämswigJ. DörffelW. SchmutzlerR.K. RhiemK. BickU. German Working Group on the Long-Term Sequelae of Hodgkin’s Disease German Consortium for Hereditary Breast and Ovarian Cancer Breast cancer in young women after treatment for Hodgkin’s disease during childhood or adolescence--an observational study with up to 33-year follow-up.Dtsch. Arztebl. Int.20141111-23924565270
     [Google Scholar]
  81. CardisE. HatchM. The Chernobyl accident--an epidemiological perspective.Clin. Oncol.201123425126010.1016/j.clon.2011.01.51021396807
     [Google Scholar]
  82. RubinoC. de VathaireF. DialloI. ShamsaldinA. LêM.G. Increased risk of second cancers following breast cancer: Role of the initial treatment.Breast Cancer Res. Treat.200061318319510.1023/A:100648991870010965995
     [Google Scholar]
  83. DePergolaG, S F Obesity as a major risk factor for cancer.J Obes2013
     [Google Scholar]
  84. HarvieM. HowellA. EvansD.G. Can diet and lifestyle prevent breast cancer: What is the evidence?Am. Soc. Clin. Oncol. Educ. Book201535e66e7310.14694/EdBook_AM.2015.35.e6625993238
     [Google Scholar]
  85. WeiderpassE. Lifestyle and cancer risk.J. Prev. Med. Public Health201043645947110.3961/jpmph.2010.43.6.45921139406
     [Google Scholar]
  86. RossiE.D. MartiniM. StracciaP. GerhardR. EvangelistaA. PontecorviA. FaddaG. Maria LaroccaL. SchmittF. Is thyroid gland only a “land” for primary malignancies? role of morphology and immunocytochemistry.Diagn. Cytopathol.201543537438010.1002/dc.2324125427948
     [Google Scholar]
  87. ZhangY. SunC. YauV. ChenS. YangQ. ChenW. LoweS. BentleyR. OuyangZ. Clinical features and prognosis of uncommon metastatic breast cancer: A retrospective analysis of 82 cases.Technol. Cancer Res. Treat.2023221533033823118499010.1177/1533033823118499037386809
     [Google Scholar]
  88. UsmaniS. AhmedN. IlyasM.W. MuradS. Al KandariF. Rare thyroid cartilage metastasis from breast cancer visualized on 18F-NaF PET/CT.Clin. Nucl. Med.2021461434410.1097/RLU.000000000000335133156044
     [Google Scholar]
  89. LeboeufR. BénardF. LangloisM.F. Thyroid cancer presenting as a pet incidentaloma in a patient with concomitant breast cancer metastases to the thyroid.Clin. Nucl. Med.200631738238510.1097/01.rlu.0000222677.50747.be16785803
     [Google Scholar]
  90. HoA.S. LuuM. ShafqatI. Mallen-St ClairJ. ChenM.M. ChenY. JainM. AliN. PatioC. FilarskiC.F. LinD.C. BankstonH. BraunsteinG.D. SacksW.L. ZumstegZ.S. Predictive impact of metastatic lymph node burden on distant metastasis across papillary thyroid cancer variants.Thyroid202131101549155710.1089/thy.2021.013134470466
     [Google Scholar]
  91. WangH. LiS. ShiJ. FengC. WangY. ZhangF. Unbalanced bidirectional causal association between thyroid cancer and ER-positive breast cancer: Should we recommend screening for thyroid cancer in breast cancer patients?BMC Genomics202324176210.1186/s12864‑023‑09854‑938082224
     [Google Scholar]
  92. GradisharW.J. MoranM.S. AbrahamJ. AftR. AgneseD. AllisonK.H. BlairS.L. BursteinH.J. DangC. EliasA.D. GiordanoS.H. GoetzM.P. GoldsteinL.J. HurvitzS.A. IsakoffS.J. JankowitzR.C. JavidS.H. KrishnamurthyJ. LeitchM. LyonsJ. MatroJ. MayerI.A. MortimerJ. O’ReganR.M. PatelS.A. PierceL.J. RugoH.S. SitapatiA. SmithK.L. SmithM.L. SolimanH. Stringer-ReasorE.M. TelliM.L. WardJ.H. WisinskiK.B. YoungJ.S. BurnsJ.L. KumarR. NCCN guidelines® insights: Breast cancer, version 4.2021: Featured updates to the NCCN guidelines.J. Natl. Compr. Canc. Netw.202119548449310.6004/jnccn.2021.002334794122
     [Google Scholar]
  93. WuY. HuangK. ZhengX. GaoM. LiuH. Tumor biology is king: Secondary tumors of the thyroid from 2 medical centers in china.Cancer Contr.202027310.1177/107327482094598432779493
     [Google Scholar]
  94. PiciuA. MesterA. RusuG. PiciuD. Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer: A case report and review of the literature of essential role of radiopharmaceuticals.Curr. Radiopharm.2021142859110.2174/187447101366620092810515132988358
     [Google Scholar]
  95. MoghaddamP.A. CornejoK.M. KhanA. Metastatic carcinoma to the thyroid gland: A single institution 20-year experience and review of the literature.Endocr. Pathol.201324311612410.1007/s12022‑013‑9257‑823872914
     [Google Scholar]
  96. StergianosS. JuhlinC.C. ZedeniusJ. CalissendorffJ. FalhammarH. Metastasis to the thyroid gland: Characterization and survival of an institutional series spanning 28 years.Eur. J. Surg. Oncol.20214761364136910.1016/j.ejso.2021.02.01833642087
     [Google Scholar]
/content/journals/ccdt/10.2174/0115680096274465240129055950
Loading
Thyroid Metastases from Breast Cancer Case Report and Literature Review
Curr. Cancer Drug Targets< 25, 83 (2025); https://doi.org/10.2174/0115680096274465240129055950
/content/journals/ccdt/10.2174/0115680096274465240129055950
/content/journals/ccdt/10.2174/0115680096274465240129055950
Loading

Data & Media loading...


  • Article Type:     Case Report
Keyword(s): Breast neoplasms; case reports; metastatic thyroid cancer; neoplasm metastasis; review; thyroid neoplasms

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test