Current Chemical Biology - Volume 6, Issue 2, 2012

The manuscript reviews the biocidal mechanisms of copper and its current uses in the fight against transmission of health-associated (nosocomial) pathogens, foodborne diseases, dust mites loads and fungal and wound infections. The manuscript also discusses possible future applications such as filtration devices capable of deactivating contaminated blood products and breastmilk.

Turkey pancreatic lipase immobilized on celite was used to produce fatty acids, diacylglycerols and monoacylglycerols by hydrolysis of palm olein in a solvent free system. Turkey lipase preparation was obtained out of a delipidated pancreatic for a biotechnological application. The effect of process variables on enzymatic hydrolysis was investigated, and the maximization of hydrolysis rate was carried out using an experimen Read More

Reactive oxygen species (ROS) are often viewed as highly unstable, degradable and transient molecules, associated only with pathological processes. However, recent studies demonstrate that one particular ROS, hydrogen peroxide (H2O2), fits the requirements of a signalling molecule, including controlled production and destruction, biological stability, and specificity in targets. The concentration, location and context in Read More

Germinal center kinases (GCKs) form a large part of the mammalian Ste20 kinase family. GCKs are involved in a variety of signaling pathways governing multiple biological processes including cell cycle, apoptosis, proliferation, cytoskeleton reorganization, cell polarity and migration, cell volume and ion transport. Dysregulation of GCKs has been linked to cell malfunction and human diseases. Despite the physiological and Read More

We have accomplished the synthesis of novel tetrahydropyrrole annulated pyranocyclohexenones and pyrimidine diones by a one pot intramolecular tandem hetero Diels Alder (IMHDA) reaction of N-substituted aldehydes with 1,3 diones (dimedone, barbituric acid). These compounds were evaluated for their antimicrobial activity against six microorganisms with ciprofloxacin as a standard drug. All the synt Read More

Protein-protein interaction networks play a central role in a large number of cellular processes. Interaction networks are regulated to a large extent through post-translational modifications. The underlying causes of many diseases are found in defective protein-protein interactions and the resulting dysregulated signaling. Study and inhibition of proteinprotein interaction networks are thus crucial to the understanding of phys Read More