Current Chemical Biology - Volume 17, Issue 4, 2023

Background: As per the Warburg effect, cancer cells are known to convert pyruvate into lactate. The accumulation of lactate is associated with metabolic and epigenetic reprogramming, which has newly been suggested to involve lactylation. However, the role of secreted lactate in modulating the tumor microenvironment through lactylation remains unclear. Specifically, there are gaps in our understanding of the en Read More

Background: Prickly pear "Opuntia ficus indica (L.) Mill. "otherwise known as the Indian fig tree, belongs to the family Cactaceae, and was known as a medicinal plant for its rich source of bioactive substances. Objective: The present work aims to promote prickly pear seeds for traditional therapy by phenolic profiling and pharmacological tests of aqueous extract. Method: An analytical quantification was performed by UV-Visible, an Read More

Background: Seafood is an important source of food for the majority of people. Marine species have a wide spectrum of pharmacological actions, including antibacterial, antiviral, antiparasitic, anti-inflammatory, and anti-diabetic properties. Objective: The purpose of this study was to examine the effects of Sepia officinalis extract (SoE) on folic acid-induced acute kidney injury in Wistar rats. Methods: A single dosage of folic acid Read More

Background: Thrombotic events and oxidative stress are major complications of certain ischemic disorders. The fight against these complications requires very intense research to develop new therapeutic agents of natural origin. Objective: The general objective of this work is the scientific valorization of five medicinal plants: Rhus pentaphylla, Zizyphus lotus, Ammodaucus leucotrichus, Inula viscosa, and Cinnamomum zeyla Read More

Background: Drug resistance is an important phenomenon in helminth parasites. Microtubules are among the key chemotherapeutic targets, mutations of which lead to drug resistance. Objectives: The present study investigated the role of F167Y, E198A, and F200Y mutations in β- tubulin protein and their effect on albendazole binding. Methods: Brugia malayi β-tubulin protein models were generated using the SwissModel Read More