Current Chemical Biology - Volume 12, Issue 2, 2018

Objective: This study investigated differences in catecholamine levels in individuals with and without sleep bruxism. Methods: A search in the databases PubMed, Cochrane Library, Scopus, Web of Science, LILACS, IADR abstracts, grey literature and in reference lists of included studies was conducted. The search was performed by two researchers, supervised by a librarian. There were no filters and no limits to language or Read More

Background: This review describes the use of molecularly imprinted polymers (MIPs) as tailor-made adsorbents for developing micro-solid phase extraction (μ-SPE) procedures when isolating/ assessing organic pollutants, drugs, and bioactive compounds from environmental, food, and clinical/ forensic samples. Objective: Developments in MIP-μ-SPE are focused on synthesizing selective MIPs before preparing micro devices, and Read More

Background: Due to increased use of antimicrobials, pathogenic bacteria have pioneered their own intrinsic resistance for antibiotics that raise the demand of inventing new antimicrobial agents. These pathogens possessed a bunch of cell transporters which confers resistance to antimicrobial agents known as efflux pump. Five major classes of efflux pumps are resistance nodulation and cell division (RND), small multidrug resist Read More

Background: 125I-insulin and 125I-IGF-I distribution during internalization is seemingly a key condition that determines hormone functional role in a given organism. Endocytosis course of 125Iinsulin and 125I-IGF-I in isolated chicken hepatocytes occurred in different ways as compared with rat hepatocytes. 125I-insulin and 125I-IGF-I distribution across cell membrane during internalization was different in bird cells. Objective: An Read More

Background: Enzyme ITPA participates in purine metabolism and its deficiency plays a role in several human diseases. There is growing evidence that ITPA polymorphism is also an important pharmacogenic phenotype, leading to a change in sensitivity to several drugs. ITPA deficiency exists in humans and is observed as elevated levels of ITP. Objective: Allele P32T-ITPA has more pronounced effects but the mechanism of enzy Read More

Background: The objective of the present study is to determine and compare TAS (Total Antioxidant Status), TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) and heavy metal content (Fe, Zn, Cu, Pb and Ni) in Pholiota limonella (Peck) Sacc. mushroom samples collected from Balikesir (Kaz Mountain National Park) and Yalova (Cinarcik, Hasan Baba Picnic Area) provinces. Methods: Mushroom TAS, TOS and OSI v Read More

Background: There are complex methods to induce type 2 diabetes as multiple low-doses streptozotocin with high fat diet administration and other combined methods which induce modest DNA damage, leading to the incomplete destruction of β cells for insulin-resistant diabetes in mice. Objective: An innovative and simple protocol was investigated to induce type 2 diabetes by only Incremental Multiple Low-Doses Strepto Read More

Background: Alzheimer's disease (AD) is the fourth largest cause of death among people over 65 years of age. Accumulation of β-amyloid and cholinergic deficiency are two prominent pathological descriptions for AD. Objective: Depletion of acetylcholine at the site of its action is thought to be the prime cause of AD. It has been reported that tetrahydrocannabinol (THC) exhibits anticholinesterase activity and it has been prop Read More

Background: The occurrence of Parkinson's Disease (PD) is associated with the deposition of proteinaceous aggregates formed by the self-assembly of α-synuclein protein. The pathogenesis of PD has been reported to be linked with the α-synuclein gene. However, the presence of missense mutations: A30P, A53T, E46K, H50Q, G51D and A53E has also been linked with the autosomal inheritance of PD. Recently, it has been hi Read More