Current Chemical Biology - Volume 10, Issue 2, 2016

The recently elucidated molecular structure of neuronal axons is based on a tubular sequence of adducin-capped actin rings connected by spectrin tetramers. It has been suggested that this structure is formed by supramolecular polymerization of repeating unimers based on spectrin tetramers bound to actin rings. The large number of spectrin molecules connected to each actin ring enormously increases the rigidity of the asse Read More

Among gastro-intestinal cancers, pancreatic cancer is the fourth leading cause of cancer-related death mainly due to late diagnosis. Although there is significant improvement in chemotherapy regimen but still five year survival rate is maximum 6%. Resistance offered by cancer stem cells towards the chemotherapeutic drug might be one solid reason behind this. Cancer stem cells (CSC), a subset of the heterogeneous cell Read More

Background: Iron-deficiency anemia (IDA) is considered the most common nutrition deficiency worldwide, which results from inadequate iron supply for erythropoiesis. Current treatments have poor chemical stability, bioavailability and some side effects. Polysaccharides have a variety of bioactivities, while no reports focused on IDA treatment by Lachnum polysaccharide iron complex. Objective: The aim of this study was t Read More

Thermotolerant yeasts, Candida easanensis strain JK-8 secreted a β-glucosidase when grown in liquid media containing various carbon sources. The greatest enzyme activity was found in medium containing 1% cellobiose as a sole carbon source. An extracellular β-glucosidase was purified to homogeneity by anion exchange chromatography and hydrophobic interaction chromatography. The molecular weight (Mw) of the β-glu Read More

Background: Forskolin, a polyhydroxylated labdone diterpene possesses various medicinal properties in the treatment of chronic diseases, in humans. The present study aimed to evaluate the interaction and binding affinity between forskolin and HSA by in silico method and spectral analysis. Methods: The in silico study for screening the interaction of forskolin with HSA protein was carried out using AutoDock Vina soft Read More

Background: Mangroves are of great significance to numerous people living along tropical shorelines. Mangroves are a rich source of various components having medicinal values. Recently, biodiversity and conservation of mangroves have been globally recognized as one of the critical issue. Objective: It is necessary to study proteins isolated from different mangroves in detail at molecular level along with their taxonomi Read More

Background: Multiple Endocrine Neoplasia Type 1 is caused by mutation in MEN1 genes that leads to parathyroid adenoma, duodenopancreatic neuroendocrine tumors, and pituitary adenomas.It also initiator of benign Lipomas, angiiofibromas and carcinoid tumor of thymus and lungs. It also incorporated in many such as transcription regulation, apoptosis, cell cycle control and DNA damage repair mechanisms. Methodology: Read More