Current Catalysis - Volume 4, Issue 3, 2015

Allyl alcohol has become an attractive feedstock for commercial organic synthesis after the development and technical-scale implementation of cost-effective methods for its manufacturing. Its major applications include hydroformylation to obtain C4 aldehyde alcohols in the presence of catalytic rhodium complexes, followed by their hydrogenation to 1,4-butanediol as the principal product. The development of phosphine Read More

In vivo, cytochrome P450 (P450) enzymes facilitate the majority of phase I metabolism of pharmaceuticals, making the identification and role of any contributing isozyme from this family a focal point in clinical trials for new chemical entities. In vitro models, traditionally used to examine metabolism, present several issues, as biological systems are inherently difficult. Interest in systems capable of replicating enzymes synt Read More

An efficient and environmentally benign diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles) have been synthesized by three-component reaction of isatoic anhydride, aromatic amines and substituted isatins using gluconic acid aqueou Read More

Gold nanoparticles, being highly recyclable and benign in nature, are nowadays emerging as an attractive choice in various catalytic reactions. Fluoride free coupling of organosilane reagents with aryl halides is an environment-friendly protocol for the formation of C-C bond. Here, we present the coupling of phenyltrimethoxysilane with various aryl halides in ethanol/water mixture, catalyzed by gold nanoparticles under Read More