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- Volume 6, Issue 1, 2019
Clinical Cancer Drugs - Volume 6, Issue 1, 2019
Volume 6, Issue 1, 2019
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Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations
More LessBreast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible for improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC). Nanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of cancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of cancer stem cells. Liposomes Read More
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Novel Molecular Targets and Mechanisms Involved in the Invasion and Metastasis of Pancreatic Cancer
Authors: Ziyi Li, Weidong Li, Yuqi Dong and Xueying SunBackground: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancerrelated deaths and its morbidity and mortality are increasing. PDAC patients have a very poor prognosis because of aggressive features of PDAC cells, shortage of reliable diagnostic biomarkers and deficiency of effective therapeutics. Objective: The article aims to discuss the recent progress in the discovery of novel molecular targets and their Read More
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Evaluation of Fibrolytic Effect of Bauhinia purpurea L.
Authors: Jeevan R. Dash, Tapas K. Sar, Rinku Buragohain, Indranil Samanta and Rahul NanotkarBackground: Mammary gland tissue (left half) revealed the presence of excess proliferation of fibrous tissue with disorganization of alveolar structures and the right half showed extensive fibrous tissue proliferation of mammary gland following intramammary inoculation of 2000 c.f.u. of Staphylococcus aureus. However, oral dosing of Bauhinia variegata L. bark powder at 6 gm/kg for 7 days and 3 gm/kg for another 7 day Read More
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A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells
Authors: Gousia Chashoo, Umed Singh, Parvinder P. Singh, Dilip M. Mondhe and Ram A. VishwakarmaBackground: Cyclin-dependent kinases play a central role in the control of cell division and therefore it is not surprising that cancer exhibits some features that disturb the normal controls over the cell cycle. Previous studies related to the development of 3-Pyrimidinylazaindole (Meriolin) derivatives as novel Cyclin dependent kinase inhibitors highlighted 4ab as the most potent inhibitor. Objective: The main objective of the Read More
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Coenzyme Q10 Attenuates Cisplatin-induced Nephrotoxicity Through Counteracting Oxidative Stress and Inflammation
Authors: Hala S. Bash and Ihsan S. RabeeaBackground: Cisplatin is an anticancer drug used in the management of solid tumors, however, dose-related nephrotoxicity is one of its major problems. Agents having antioxidants, antiinflammatory and/or antiapoptotic activities may thus represent potential therapeutic options to avoid cisplatin-induced nephrotoxicity. Among these agents, coenzyme Q10 has several pharmacological properties including antioxidant, anti- Read More
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Head and Neck Cancer with Lung Metastases: Treatment Challenges
Authors: Selvamalar Vengathajalam and Norhafiza M. LazimBackground: Head and neck cancer has predilection of metastasising to the lung, bones or liver. The site of metastasis usually depends on the primary tumour location, the staging and the regional spread of the tumour. Patients with distant metastasis are predicted to have a poor prognosis with low survival rate. Oligometastasis is the term used for an intermediate biologic state of restricted metastatic capacity with limited n Read More
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