Current Biomarkers (Discontinued) - Volume 6, Issue 2, 2016

Background: Acute kidney injury is a common clinical problem that is associated with substantially increased morbidity and mortality. Biomarkers of AKI can be identified from urine, blood or other samples to aide in early detection, prognostication, and to guide treatment decisions. In addition, biomarkers may represent potential treatment targets for targeted therapy of this syndrome. This is especially important since thus far, Read More

Background: In many cancers, predictive factors are important for recognition of high-risk patients and amongst individualizing treatment. The understanding of these mechanisms might provide novel and useful approaches for preventing, diagnosing and treating different cancers. Objective: The main objective of this review is to extend the current knowledge on the various tumor biomarkers targeting prognosis an Read More

Background: Androgens play a major role in the carcinogenesis of prostate cancer (PCa) and the growth of PCa cells is based on the level of androgens. New Gene Expressed in Prostate (NGEP) and LIM-domain-only1 (LMO1) are two proteins that seem to play important roles in prognosis and progress of PCa, respectively. Previous studies reported androgen-dependent NGEP and LMO1 translocation into the nucleus associ Read More

Background: There is high risk of left ventricular hypertrophy (LVH) in hemodialysis patients and attention is required to address this problem. Till date most of the proteomics studies in Chronic Kidney Disease (CKD) have been carried out in urine samples and have revealed some important protein biomarkers. Objective: The current study was undertaken to evaluate the serum proteomic profile in hemodialysis patients with Read More

Background: Peripheral blood stem cells (PBSCs) are now established curative treatment for patients with various hematologic malignancies and are proposed to be superior to other cell sources for cell based therapy. Aims: The aims are to characterize the PBSCs by constructing proteome using 2D-gel electrophoresis and analyze the kinetic parameters of pirarubicin transport of PBSCs compared with peripheral blood mono Read More

Background: Inflammatory cytokines play a major role in pathophysiology, prognosis and progression in HIV infection. Studies on pre-ART levels of different pro-inflammatory and coagulation markers have shown predictive role on progression and mortality in HIV. IL-6, CRP has also been shown to be correlated with HIV-RNA levels as disease progresses. Objective: Biomarkers of inflammation are of increasing interest as predicto Read More