Current Biomarkers (Discontinued) - Volume 6, Issue 1, 2016

Nitric Oxide (NO) is an important, rapid assay biomarker of many known diseases, including asthma, chronic obstructive pulmonary disease (COPD) as well as other respiratory infections, septic shock, Parkinson's diseases and Alzheimer's dementia. Therefore, the detection and measurement of NO in a physiological fluid, either in gas or in liquid phase, are scientifically and clinically significant. The objective of this research is to d Read More

Background: Thyroid cancers are frequent in the endocrine system especially differentiated thyroid carcinoma and 95% of all thyroid cancer cases are differentiated neoplasmas. They have a favorable prognosis; however although, a small group present recurrence in 10-15% of patients following the standard treatment, surgery and radioiodine. Medullary thyroid carcinoma which is a neoplasm of the parafollicular C cells Read More

Gastrointestinal cancers remain a significant health problem worldwide. Resistance to treatment in a subset of patients is a major problem and personalized treatment is expected to improve prognosis in these individuals. Assessment of biomarkers, which are generally genes, proteins, phosphoproteins and/or microRNAs (miRNAs), and their levels in tumor or blood, leads to a view of the molecular characteristics (signat Read More

Background: CD133 is a widely used cancer stem cell marker for many cancers. Scientometric analysis is a reliable and practical method that enables us to get more information on CD133. To our knowledge, there is no bibliometric study on CD133. So, an overview of the general trend of CD133 is important for scientific researchers. Methods: In this study, data extraction was performed using the semantic search engine ‘ Read More

Background: Carbonic anhydrase is a metalloenzyme extensively present in nature. In animals, it is involved in several functions such as respiration, pH homeostasis, salt transport, metabolic reactions, calcification, bone resorption. In recent years, the CA wide distribution, relevance in several physiological processes, involvement in several pathological conditions, as well as sensitivity to chemical pollutants has driven the resear Read More

Background: The problem of diabetes and associated treatments had mentioned herbal plants in several studies. The cardioactive Terminalia arjuna has also been reported for antidiabetic principles yet no scientific evidence is available. Hence, an attempt has been made by the authors to find the probable mechanism and biomarker involved for α-amylase enzyme inhibition Objective: The extraction of bark of Terminalia arj Read More

Background: In acute coronary syndrome (ACS), nitric oxide is generated in excess during ischemic attack due to marked activation of the inducible nitric oxide synthase (iNOS) enzyme by different cytokines. Consequently, serious damaging effects result. Objective: To explore the potential role of iNOS mRNA expression as a marker of acute ischemia in ACS patients and as a predictor of the attack outcome. Method: Forty-eight AC Read More

Setting: We investigated the usefulness of bone markers, respectively Procollagen Type I Aminoterminal Propeptide (PINP) and Beta-Crosslaps (β-CTx) for diagnosis, treatment and monitoring of charges with histologically confirmed breast neoplasm. The intention of this project was the demonstration of the impact of the osseous fluctuation markers PINP on the one hand and β-CTx on the other hand for the verification o Read More