Current Bioinformatics - Volume 15, Issue 1, 2020

Transcriptome assembly plays a critical role in studying biological properties and examining the expression levels of genomes in specific cells. It is also the basis of many downstream analyses. With the increase of speed and the decrease in cost, massive sequencing data continues to accumulate. A large number of assembly strategies based on different computational methods and experiments have been developed. Read More

Background: Germin-like Proteins (GLPs) play an important role in various stresses. Rice contains 43 GLPs, among which many remain functionally unexplored. The computational analysis will provide significant insight into their function. Objective: To find various structural properties, functional importance, phylogeny and expression pattern of all OsGLPs using various bioinformatics tools. Methods: Physiochemical properties, sub Read More

Background: SnoRNAs (Small nucleolar RNAs) are small RNA molecules with approximately 60-300 nucleotides in sequence length. They have been proved to play important roles in cancer occurrence and progression. It is of great clinical importance to identify new snoRNAs as fast and accurately as possible. Objective: A novel algorithm, ESDA (Elastically Sparse Partial Least Squares Discriminant Analysis), was proposed Read More

Background: Exploring various functional aspects of a biological cell system has been a focused research trend for last many decades. Biologists, scientists and researchers are continuously striving for unveiling the mysteries of these functional aspects to improve the health standards of life. For getting such understanding, astronomically growing, heterogeneous and geographically dispersed omics data needs to be critically a Read More

Aims: Post-Translational Modifications (PTMs), which include more than 450 types, can be regarded as the fundamental cellular regulation. Background: Recently, experiments demonstrated that the lysine malonylation modification is a significant process in several organisms and cells. Meanwhile, malonylation plays an important role in the regulation of protein subcellular localization, stability, translocation to lipid rafts a Read More

Background: Identifying Drug-Target Interactions (DTIs) is a major challenge for current drug discovery and drug repositioning. Compared to traditional experimental approaches, in silico methods are fast and inexpensive. With the increase in open-access experimental data, numerous computational methods have been applied to predict DTIs. Methods: In this study, we propose an end-to-end learning model of Factoriza Read More

Background: Previous studies indicated that the cell fate of neural stem cells (NSCs) after differentiation is determined by Smek1, one isoform of suppressor of Mek null (Smek). Smek deficiency prevents NSCs from differentiation, thus affects the development of nervous system. In recent years, lncRNAs have been found to participate in numerous developmental and biological pathways. However, the effects of knocking o Read More