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Current Bioactive Compounds - Volume 16, Issue 4, 2020

Volume 16, Issue 4

Volume 16, Issue 4, 2020

- 3,6-dichloro-1,2,4,5-Tetrazine Assayed at High Doses in the Metastatic Breast Cancer Cell Line MDA-MB-231 Reduces Cell Numbers and Induces Apoptosis
  
  Authors: Mohamed Abdelkarim, Khaoula Ben Younes, Ines Limam, Refka Guermazi, Amel B. A. ElGaaied and Fatma B. Aissa-Fennira
  
  https://doi.org/10.2174/1573407215666181224105826
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  Background: The lack of treatment options for patients with chemotherapy-resistant cancers is pushing the field toward the development of new therapies. 1,2,4,5-tetrazine derivatives are a class of heterocyclic compounds that exhibit a broad spectrum of antitumor activities. Objective: The purpose of this study was to assess the biological activity of four s-tetrazine derivatives by substitution of two chloride atom of 3,6-dichlo Read More
  
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