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2000
Volume 16, Issue 7
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Background: Meso-tetra-4-actophenyl-porphyrin (TAcPPH) was synthesized by reacting 4- acetyl-benzaldehyde with pyrrole in propionic acid, and used as a ligand for the synthesis of palladium (II) complex (PdTAcPP). The structure of the ligand and the complex were characterized by NMR and electronic spectroscopy. Methods: The antioxidant activity and the binding parameters of both the ligand and its complex with superoxide anion radical . (O -) were measured using cyclic voltammetry based assay. The assays were based on the measurement of the anodic peak current density of . O− electrochemically generated by reduction of molecular oxygen in DMF. Results: The complex PdTAcPP showed the highest antioxidant activity (0.73 ± 0.01 mg/mL) which is four times higher than that of the standard antioxidant α-tocopherol (3.04 ± 0.03 mg/mL). Discussion: Binding parameters like binding constants, the ratio of binding constants and binding free energies were also measured. Conclusions: The value of the binding free energy ranging from -7.89 kJmol-1 for TAcPPH to -17.59 kJ.mol-1for PdTAcPP suggests an electrostatic interaction of . O− with TAcPPH2 and PdTAcPP which has been found to be the dominant interaction mode. The kinetics of the interaction reaction of the ligand and complex was quantified having second-order rate constant values equal to 0.2 and 1.3 M-1 s-1, respectively.

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/content/journals/cbc/10.2174/1573407215666191017105239
2020-10-01
2025-07-07
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