Threonine-Proline-Chimeras, A Valuable Building Block for Peptidomimetic Design: A Review

Threonine-proline chimeras are not so abundant in nature as the other proine-chimeras and their functionalization is also restricted to the third position on the pyrrolidine ring. Despite these aspects the synthetic procedures adopted to obtain these products are straightforward and well-described in literature, as reported in the following review.