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- ISSN: 1573-4072
- E-ISSN: 1875-6646
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Synthetic Strategies for Lysine-Proline Chimeras: An Overview
- Source: Current Bioactive Compounds, Volume 12, Issue 3, Sep 2016, p. 191 - 199
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- 01 Sep 2016
Abstract
Proline-amino acid chimeras are conformationally rigid amino acid analogues, important in understanding the spatial requirements for receptor affinity and biological activity of natural amino acids and peptides. In medicinal chemistry, a great variety of lysine-proline chimeras was considered in light of the importance of their biological roles. In this review, we analyze the most relevant synthetic approaches to obtain lysine-proline chimeras.
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