Current Aging Science - Volume 9, Issue 2, 2016

There is no doubt that the world is divided and unequal, mostly with respect to wealth. However, the true obstacle preventing the progress of humanity is not the divide between the rich and the poor. It is the divide between the cognitive and the physical. Apart from the social and ethical issues associated with this, there are also medical ones. The implications of this divide have direct relevance to aging, both in research a Read More

It is proposed that a primary and fundamental aspect of metazoan evolution is an ability to control and extend the longevity of individual cells. This was achieved through an intracellular oscillator, dubbed ‘Life’s Timekeeper’, which evolved in the hypothetical ancestor of all metazoans. Slower oscillatory frequencies directed metazoan evolution towards extended longevity of individual cells, enabling generation of many speciali Read More

Every year, millions of people affected by disorders of the central nervous system (CNS) undergo various diagnostic, therapeutic and surgical procedures requiring administration of anesthetic agents. Anesthetics exert their anesthetic, amnesic and analgesic effects by acting on multiple neuronal membrane proteins in the CNS. While some of the causal anesthetic targets have been identified, a large number of anestheti Read More

Background: Age-related decline in cognitive flexibility and learning contributes to poorer quality of life. Thus, it is important to develop procedures that minimize age-related cognitive decline. Previous research has shown that, when young adult rats were trained in an attention-demanding task with a distracter, they learned a new task more quickly compared with rats trained in the same attention- demanding task without a dist Read More

Background: Polypharmacy is a key problem for those ≥65. Objective: To summarise for individuals ≥65 the rates of Potentially Inappropriate Medications (PIMs) identified by application of STOPP, and Potential Prescribing Omissions (PPOs) by START criteria. Methods: Search: Databases were searched 1980 to 1 December 2015. For Medline the search yielded 3,691 systematic reviews or meta-analyses and 301 when limi Read More