Current Alzheimer Research - Volume 18, Issue 11, 2021

Background: As new biomolecular targets for Alzheimer’s disease (AD) emerge, there is a tendency to regard these as mutually exclusive and in competition, culminating in declarations that since the “amyloid hypothesis is dead” it needs to be replaced by completely different theories. However, given the well-described role of misfolding peptides, particularly β-amyloid (Aβ), in the pathogenesis of AD, the need for a bro Read More

The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased, with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more beneficial since there is no cure for AD. This review ma Read More

Objective: This study assessed the ability of patients with Alzheimer’s Disease (AD) to produce “when, where, and who” information during future thinking. Methods: AD patients and control participants were invited to imagine future scenarios. Future thinking was analyzed with respect to the number of “when, where, and who” details. Analysis showed fewer “when, where, and who” details in AD participants than in control par Read More

Background: Alzheimer's disease (AD) is still one of the major threats to human health. Although a satisfactory treatment for AD has not yet been discovered, it is necessary to continue to search for novel approaches to deal with this insidious and debilitating disease. Although numerous studies have shown that long non-coding RNA (lncRNA) occupy a significant role in a variety of diseases, their roles in AD remain unclear Read More

Background: The Benton Visual Retention Test (BVRT) is a well-validated and reliable test for assessing visual memory and visuospatial function. However, the association between the BVRT score and imaging biomarker of Alzheimer’s disease (AD) remains unclear. Objective: This study examined whether the BVRT score is associated with brain amyloid burden and cortical glucose metabolism in elderly adults without de Read More