Skip to content
2000
image of Use of Virtual Reality to Improve Spatial Orientation in Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review

Abstract

Background

Alzheimer's disease is a chronic, neurodegenerative condition that leads to a significant cognitive decline. One of the symptoms that greatly reduces the quality of daily functioning is the deterioration of spatial orientation abilities. A non-pharmacological treatment option for Alzheimer's disease, which is also employed to improve the cognitive functioning of individuals with mild cognitive impairment, is virtual reality training.

Objective

To the best of the authors' knowledge, there is no existing systematic review on the use of virtual reality training to enhance spatial orientation in individuals with Alzheimer’s disease or mild cognitive impairment. The review was therefore conducted to fill this gap. The findings of this review may support the efficacy of virtual reality in enhancing spatial orientation.

Methods

Five databases were searched. The primary inclusion criteria were study participants aged over 60 years with a diagnosis of Alzheimer's disease or mild cognitive impairment and the use of virtual reality for improving spatial orientation. Six studies meeting these criteria were ultimately included in the review.

Results

All included studies demonstrated an improvement in the spatial orientation of individuals with Alzheimer's disease or mild cognitive impairment following virtual reality training. This indicates the effectiveness of virtual reality technology in cognitive rehabilitation.

Conclusion

As virtual reality cognitive training has proven effective, its use should be more widely adopted. Further research on the application of virtual reality for enhancing spatial orientation in individuals with dementia is recommended.

Loading

Article metrics loading...

/content/journals/car/10.2174/0115672050374807250224044204
2025-02-26
2025-03-27
Loading full text...

Full text loading...

References

  1. McKhann G.M. Knopman D.S. Chertkow H. Hyman B.T. Jack C.R. Jr Kawas C.H. Klunk W.E. Koroshetz W.J. Manly J.J. Mayeux R. Mohs R.C. Morris J.C. Rossor M.N. Scheltens P. Carrillo M.C. Thies B. Weintraub S. Phelps C.H. The diagnosis of dementia due to alzheimer’s disease: Recommendations from the national institute on aging‐alzheimer’s association workgroups on diagnostic guidelines for alzheimer’s disease. Alzheimers Dement. 2011 7 3 263 269 10.1016/j.jalz.2011.03.005 21514250
    [Google Scholar]
  2. Lopez S.J.A. González H.M. Léger G.C. Alzheimer’s disease. Handb. Clin. Neurol. 2019 167 231 255 10.1016/B978‑0‑12‑804766‑8.00013‑3 31753135
    [Google Scholar]
  3. Pashmdarfard M. Azad A. Assessment tools to evaluate activities of daily living (adl) and instrumental activities of daily living (IADL) in older adults: A systematic review. Med. J. Islam Rep. Iran. 2020 34 33 10.34171/mjiri.34.33
    [Google Scholar]
  4. Yu J. Wu J. Liu B. Zheng K. Ren Z. Efficacy of virtual reality technology interventions for cognitive and mental outcomes in older people with cognitive disorders: An umbrella review comprising meta-analyses of randomized controlled trials. Ageing Res. Rev. 2024 94 102179 10.1016/j.arr.2023.102179 38163517
    [Google Scholar]
  5. Jorm A.F. Korten A.E. Henderson A.S. The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatr. Scand. 1987 76 5 465 479 10.1111/j.1600‑0447.1987.tb02906.x 3324647
    [Google Scholar]
  6. Bessey L.J. Walaszek A. Management of Behavioral and Psychological Symptoms of Dementia. Curr. Psychiatry Rep. 2019 21 8 66 10.1007/s11920‑019‑1049‑5 31264056
    [Google Scholar]
  7. Desai A.K. Schwartz L. Grossberg G.T. Behavioral disturbance in dementia. Curr. Psychiatry Rep. 2012 14 4 298 309 10.1007/s11920‑012‑0288‑5 22644311
    [Google Scholar]
  8. Tible O.P. Riese F. Savaskan E. Gunten V.A. Best practice in the management of behavioural and psychological symptoms of dementia. Ther. Adv. Neurol. Disord. 2017 10 8 297 309 10.1177/1756285617712979 28781611
    [Google Scholar]
  9. Cipriani G. Danti S. Picchi L. Nuti A. Fiorino M.D. Daily functioning and dementia. Dement. Neuropsychol. 2020 14 2 93 102 10.1590/1980‑57642020dn14‑020001 32595877
    [Google Scholar]
  10. Jones D. A family living with Alzheimer’s disease: The communicative challenges. Dementia 2015 14 5 555 573 10.1177/1471301213502213 24339113
    [Google Scholar]
  11. O’Neil H.A. Fletcher P.C. “Sometimes life throws you a curve ball”. Clin. Nurse Spec. 2021 35 6 318 326 10.1097/NUR.0000000000000635 34606212
    [Google Scholar]
  12. Schaber P. Blair K. Jost E. Schaffer M. Thurner E. Understanding family interaction patterns in families with alzheimer’s disease. OTJR 2016 36 1 25 33 10.1177/1539449215610566 27504690
    [Google Scholar]
  13. Botto R. Callai N. Cermelli A. Causarano L. Rainero I. Anxiety and depression in Alzheimer’s disease: A systematic review of pathogenetic mechanisms and relation to cognitive decline. Neurol. Sci. 2022 43 7 4107 4124 10.1007/s10072‑022‑06068‑x 35461471
    [Google Scholar]
  14. Chi S. Yu J.T. Tan M.S. Tan L. Depression in Alzheimer’s disease: Epidemiology, mechanisms, and management. J. Alzheimers Dis. 2014 42 3 739 755 10.3233/JAD‑140324 24946876
    [Google Scholar]
  15. Ferretti L. McCurry S.M. Logsdon R. Gibbons L. Teri L. Anxiety and Alzheimer’s disease. J. Geriatr. Psychiatry Neurol. 2001 14 1 52 58 10.1177/089198870101400111 11281317
    [Google Scholar]
  16. Leung D.K.Y. Chan W.C. Spector A. Wong G.H.Y. Prevalence of depression, anxiety, and apathy symptoms across dementia stages: A systematic review and meta‐analysis. Int. J. Geriatr. Psychiatry 2021 36 9 1330 1344 10.1002/gps.5556 33905138
    [Google Scholar]
  17. Lyketsos C.G. Carrillo M.C. Ryan J.M. Khachaturian A.S. Trzepacz P. Amatniek J. Cedarbaum J. Brashear R. Miller D.S. Neuropsychiatric symptoms in Alzheimer’s disease. Alzheimers Dement. 2011 7 5 532 539 10.1016/j.jalz.2011.05.2410 21889116
    [Google Scholar]
  18. Mendez M.F. The relationship between anxiety and alzheimer’s disease. J. Alzheimers Dis. Rep. 2021 5 1 171 177 10.3233/ADR‑210294 33981954
    [Google Scholar]
  19. Perri R. Turchetta C.S. Caruso G. Fadda L. Caltagirone C. Carlesimo G.A. Neuropsychological correlates of cognitive, emotional-affective and auto-activation apathy in Alzheimer's disease. Neuropsychologia 2018 118 Pt B 12 21 10.1016/j.neuropsychologia.2018.01.039
    [Google Scholar]
  20. Rodríguez C.B. Castiñeira R.B. Nunes C.L. Alzheimer's disease and quality of life of the informal caregiver. Rev. Esp. Geriatr. Gerontol. 2019 54 2 81 87 10.1016/j.regg.2018.10.008 30792138
    [Google Scholar]
  21. Grabher B.J. Effects of alzheimer disease on patients and their family. J. Nucl. Med. Technol. 2018 46 4 335 340 10.2967/jnmt.118.218057 30139888
    [Google Scholar]
  22. Hellis E. Mukaetova-Ladinska E.B. Informal caregiving and alzheimer’s disease: The psychological effect. Medicina 2022 59 1 48 10.3390/medicina59010048 36676672
    [Google Scholar]
  23. Rosa R.D.L. Simões-Neto J.P. Santos R.L. Torres B. Baptista M.A.T. Kimura N.R.S. Dourado M.C.N. Caregivers’ resilience in mild and moderate Alzheimer’s disease. Aging Ment. Health 2020 24 2 250 258 10.1080/13607863.2018.1533520 30499333
    [Google Scholar]
  24. Burks H.B. Bordes D.J.K.A. Chadha R. Holmes H.M. Rianon N.J. Quality of life assessment in older adults with dementia: A systematic review. Dement. Geriatr. Cogn. Disord. 2021 50 2 103 110 10.1159/000515317 34167127
    [Google Scholar]
  25. Chen Y.X. Liang N. Li X.L. Yang S.H. Wang Y.P. Shi N.N. Diagnosis and treatment for mild cognitive impairment: A systematic review of clinical practice guidelines and consensus statements. Front. Neurol. 2021 12 719849 10.3389/fneur.2021.719849 34712197
    [Google Scholar]
  26. Hughes T.F. Chang C.C.H. Bilt J.V. Snitz B.E. Ganguli M. Mild cognitive deficits and everyday functioning among older adults in the community: The Monongahela-Youghiogheny Healthy Aging Team study. Am. J. Geriatr. Psychiatry 2012 20 10 836 844 10.1097/JGP.0b013e3182423961 22337146
    [Google Scholar]
  27. Petersen R.C. Roberts R.O. Knopman D.S. Geda Y.E. Cha R.H. Pankratz V.S. Boeve B.F. Tangalos E.G. Ivnik R.J. Rocca W.A. Prevalence of mild cognitive impairment is higher in men. Neurology 2010 75 10 889 897 10.1212/WNL.0b013e3181f11d85 20820000
    [Google Scholar]
  28. Boccia M. Vita D.A. Diana S. Margiotta R. Imbriano L. Rendace L. Campanelli A. D’Antonio F. Trebbastoni A. Lena D.C. Piccardi L. Guariglia C. Is losing one’s way a sign of cognitive decay? topographical memory deficit as an early marker of pathological aging. J. Alzheimers Dis. 2019 68 2 679 693 10.3233/JAD‑180890 30883347
    [Google Scholar]
  29. Kavcic V. Duffy C.J. Attentional dynamics and visual perception: Mechanisms of spatial disorientation in Alzheimer’s disease. Brain 2003 126 5 1173 1181 10.1093/brain/awg105 12690056
    [Google Scholar]
  30. Monacelli A.M. Cushman L.A. Kavcic V. Duffy C.J. Spatial disorientation in Alzheimer’s disease. Neurology 2003 61 11 1491 1497 10.1212/WNL.61.11.1491 14663030
    [Google Scholar]
  31. Chiu Y.C. Algase D. Whall A. Liang J. Liu H.C. Lin K.N. Wang P.N. Getting lost: Directed attention and executive functions in early Alzheimer’s disease patients. Dement. Geriatr. Cogn. Disord. 2004 17 3 174 180 10.1159/000076353 14739541
    [Google Scholar]
  32. deIpolyi A.R. Rankin K.P. Mucke L. Miller B.L. Gorno-Tempini M.L. Spatial cognition and the human navigation network in AD and MCI. Neurology 2007 69 10 986 997 10.1212/01.wnl.0000271376.19515.c6 17785667
    [Google Scholar]
  33. Puthusseryppady V. Morrissey S. Spiers H. Patel M. Hornberger M. Predicting real world spatial disorientation in Alzheimer’s disease patients using virtual reality navigation tests. Sci. Rep. 2022 12 1 13397 10.1038/s41598‑022‑17634‑w 35927285
    [Google Scholar]
  34. Allison S.L. Fagan A.M. Morris J.C. Head D. Spatial navigation in preclinical alzheimer's disease. J. Alzheimers Dis. 2016 52 1 77 90 10.3233/JAD‑150855
    [Google Scholar]
  35. Henderson V.W. Mack W. Williams B.W. Spatial disorientation in Alzheimer’s disease. Arch. Neurol. 1989 46 4 391 394 10.1001/archneur.1989.00520400045018 2705898
    [Google Scholar]
  36. Vlček K. Laczó J. Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer’s disease. Front. Behav. Neurosci. 2014 8 89 10.3389/fnbeh.2014.00089 24672452
    [Google Scholar]
  37. United nations. world population ageing 2020. highlights. 2020 Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf
  38. Global Health and Aging. 2021 Available from: https://www.nia.nih.gov/sites/default/files/2017-06/global_health_aging.pdf
  39. Ageing and health. 2021 Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health
  40. World health organization. dementia. 2024 Available from: https://www.who.int/news-room/fact-sheets/detail/dementia
  41. 2024 Alzheimer’s disease facts and figures. Alzheimers Dement. 2024 20 5 3708 3821 10.1002/alz.13809 38689398
    [Google Scholar]
  42. Hong Y.C. Aging society and environmental health challenges. Environ. Health Perspect. 2013 121 3 A68 A69 10.1289/ehp.1206334 23454410
    [Google Scholar]
  43. Rowe J.W. Challenges for middle-income elders in an aging society. Health Aff. 2019 38 5 101377hlthaff201900095 10.1377/hlthaff.2019.00095
    [Google Scholar]
  44. Wang H.X. MacDonald S.W.S. Dekhtyar S. Fratiglioni L. Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study. PLoS Med. 2017 14 3 e1002251 10.1371/journal.pmed.1002251 28291786
    [Google Scholar]
  45. Nichols E. Steinmetz J.D. Vollset S.E. Fukutaki K. Chalek J. Abd-Allah F. Abdoli A. Abualhasan A. Abu-Gharbieh E. Akram T.T. Hamad A.H. Alahdab F. Alanezi F.M. Alipour V. Almustanyir S. Amu H. Ansari I. Arabloo J. Ashraf T. Astell-Burt T. Ayano G. Ayuso-Mateos J.L. Baig A.A. Barnett A. Barrow A. Baune B.T. Béjot Y. Bezabhe W.M.M. Bezabih Y.M. Bhagavathula A.S. Bhaskar S. Bhattacharyya K. Bijani A. Biswas A. Bolla S.R. Boloor A. Brayne C. Brenner H. Burkart K. Burns R.A. Cámera L.A. Cao C. Carvalho F. Castro-de-Araujo L.F.S. Catalá-López F. Cerin E. Chavan P.P. Cherbuin N. Chu D-T. Costa V.M. Couto R.A.S. Dadras O. Dai X. Dandona L. Dandona R. la Cruz-Góngora D.V. Dhamnetiya D. Dias da Silva D. Diaz D. Douiri A. Edvardsson D. Ekholuenetale M. Sayed E.I. El-Jaafary S.I. Eskandari K. Eskandarieh S. Esmaeilnejad S. Fares J. Faro A. Farooque U. Feigin V.L. Feng X. Fereshtehnejad S-M. Fernandes E. Ferrara P. Filip I. Fillit H. Fischer F. Gaidhane S. Galluzzo L. Ghashghaee A. Ghith N. Gialluisi A. Gilani S.A. Glavan I-R. Gnedovskaya E.V. Golechha M. Gupta R. Gupta V.B. Gupta V.K. Haider M.R. Hall B.J. Hamidi S. Hanif A. Hankey G.J. Haque S. Hartono R.K. Hasaballah A.I. Hasan M.T. Hassan A. Hay S.I. Hayat K. Hegazy M.I. Heidari G. Heidari-Soureshjani R. Herteliu C. Househ M. Hussain R. Hwang B-F. Iacoviello L. Iavicoli I. Ilesanmi O.S. Ilic I.M. Ilic M.D. Irvani S.S.N. Iso H. Iwagami M. Jabbarinejad R. Jacob L. Jain V. Jayapal S.K. Jayawardena R. Jha R.P. Jonas J.B. Joseph N. Kalani R. Kandel A. Kandel H. Karch A. Kasa A.S. Kassie G.M. Keshavarz P. Khan M.A.B. Khatib M.N. Khoja T.A.M. Khubchandani J. Kim M.S. Kim Y.J. Kisa A. Kisa S. Kivimäki M. Koroshetz W.J. Koyanagi A. Kumar G.A. Kumar M. Lak H.M. Leonardi M. Li B. Lim S.S. Liu X. Liu Y. Logroscino G. Lorkowski S. Lucchetti G. Saute L.R. Magnani F.G. Malik A.A. Massano J. Mehndiratta M.M. Menezes R.G. Meretoja A. Mohajer B. Ibrahim M.N. Mohammad Y. Mohammed A. Mokdad A.H. Mondello S. Moni M.A.A. Moniruzzaman M. Mossie T.B. Nagel G. Naveed M. Nayak V.C. Kandel N.S. Nguyen T.H. Oancea B. Otstavnov N. Otstavnov S.S. Owolabi M.O. Panda-Jonas S. Kan P.F. Pasovic M. Patel U.K. Pathak M. Peres M.F.P. Perianayagam A. Peterson C.B. Phillips M.R. Pinheiro M. Piradov M.A. Pond C.D. Potashman M.H. Pottoo F.H. Prada S.I. Radfar A. Raggi A. Rahim F. Rahman M. Ram P. Ranasinghe P. Rawaf D.L. Rawaf S. Rezaei N. Rezapour A. Robinson S.R. Romoli M. Roshandel G. Sahathevan R. Sahebkar A. Sahraian M.A. Sathian B. Sattin D. Sawhney M. Saylan M. Schiavolin S. Seylani A. Sha F. Shaikh M.A. Shaji K.S. Shannawaz M. Shetty J.K. Shigematsu M. Shin J.I. Shiri R. Silva D.A.S. Silva J.P. Silva R. Singh J.A. Skryabin V.Y. Skryabina A.A. Smith A.E. Soshnikov S. Spurlock E.E. Stein D.J. Sun J. Tabarés-Seisdedos R. Thakur B. Timalsina B. Tovani-Palone M.R. Tran B.X. Tsegaye G.W. Tahbaz V.S. Valdez P.R. Venketasubramanian N. Vlassov V. Vu G.T. Vu L.G. Wang Y-P. Wimo A. Winkler A.S. Yadav L. Jabbari Y.S.H. Yamagishi K. Yang L. Yano Y. Yonemoto N. Yu C. Yunusa I. Zadey S. Zastrozhin M.S. Zastrozhina A. Zhang Z-J. Murray C.J.L. Vos T. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lan. Pub. Health 2022 7 2 e105 e125 10.1016/S2468‑2667(21)00249‑8 34998485
    [Google Scholar]
  46. Li X. Feng X. Sun X. Hou N. Han F. Liu Y. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2019. Front. Aging Neurosci. 2022 14 937486 10.3389/fnagi.2022.937486 36299608
    [Google Scholar]
  47. Seitz D.P. Brisbin S. Herrmann N. Rapoport M.J. Wilson K. Gill S.S. Rines J. Clair L.K. Conn D. Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: A systematic review. J. Am. Med. Dir. Assoc. 2012 13 6 503 506.e2 10.1016/j.jamda.2011.12.059 22342481
    [Google Scholar]
  48. Spector A. Thorgrimsen L. Woods B. Royan L. Davies S. Butterworth M. Orrell M. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia. Br. J. Psychiatry 2003 183 3 248 254 10.1192/bjp.183.3.248 12948999
    [Google Scholar]
  49. Zhong D. Chen L. Feng Y. Song R. Huang L. Liu J. Zhang L. Effects of virtual reality cognitive training in individuals with mild cognitive impairment: A systematic review and meta‐analysis. Int. J. Geriatr. Psychiatry 2021 36 12 1829 1847 10.1002/gps.5603 34318524
    [Google Scholar]
  50. Srivastava P. Tripathi P.N. Sharma P. Rai S.N. Singh S.P. Srivastava R.K. Shankar S. Shrivastava S.K. Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory. Eur. J. Med. Chem. 2019 163 163 116 135 10.1016/j.ejmech.2018.11.049 30503937
    [Google Scholar]
  51. Tripathi P.N. Srivastava P. Sharma P. Tripathi M.K. Seth A. Tripathi A. Rai S.N. Singh S.P. Shrivastava S.K. Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory. Bioorg. Chem. 2019 85 82 96 10.1016/j.bioorg.2018.12.017 30605887
    [Google Scholar]
  52. Singh M. Agarwal V. Pancham P. Jindal D. Agarwal S. Rai S. Singh S. Gupta V. A comprehensive review and androgen deprivation therapy and its impact on alzheimer’s disease risk in older men with prostate cancer. Degener. Neurol. Neuromuscul. Dis. 2024 14 14 33 46 10.2147/DNND.S445130 38774717
    [Google Scholar]
  53. Rai S.N. Singh C. Singh A. Singh M.P. Singh B.K. Mitochondrial dysfunction: A potential therapeutic target to treat alzheimer’s disease. Mol. Neurobiol. 2020 57 7 3075 3088 10.1007/s12035‑020‑01945‑y 32462551
    [Google Scholar]
  54. Tripathi P. Lodhi A. Rai S. Nandi N. Dumoga S. Yadav P. Tiwari A. Singh S. El-Shorbagi A.N. Chaudhary S. Review of pharmacotherapeutic targets in alzheimer’s disease and its management using traditional medicinal plants. Degener. Neurol. Neuromuscul. Dis. 2024 14 14 47 74 10.2147/DNND.S452009 38784601
    [Google Scholar]
  55. Bleibel M. Cheikh E.A. Sadier N.S. Abou-Abbas L. The effect of music therapy on cognitive functions in patients with Alzheimer’s disease: A systematic review of randomized controlled trials. Alzheimers Res. Ther. 2023 15 1 65 10.1186/s13195‑023‑01214‑9 36973733
    [Google Scholar]
  56. Blackman J. Swirski M. Clynes J. Harding S. Leng Y. Coulthard E. Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review. J. Sleep Res. 2021 30 4 e13229 10.1111/jsr.13229
    [Google Scholar]
  57. Cámara-Calmaestra R. Martínez-Amat A. Aibar-Almazán A. Hita-Contreras F. Hernando M.D.N. Achalandabaso-Ochoa A. Effectiveness of physical exercise on alzheimer’s disease. a systematic review. J. Prev. Alzheimers Dis. 2022 9 4 601 616 10.14283/jpad.2022.57 36281664
    [Google Scholar]
  58. Huynh Q.S. Elangovan S. Holsinger R.M.D. Non-pharmacological therapeutic options for the treatment of alzheimer’s disease. int. j. mol. sci. 2022 23 19 11037 10.3390/ijms231911037 36232336
    [Google Scholar]
  59. Kim D. The effects of a recollection-based occupational therapy program of alzheimer's disease: A randomized controlled trial. Occup. Ther. Int. 2020 2020 6305727 10.1155/2020/6305727
    [Google Scholar]
  60. Lök N. Bademli K. Selçuk-Tosun A. The effect of reminiscence therapy on cognitive functions, depression, and quality of life in Alzheimer patients: Randomized controlled trial. Int. J. Geriatr. Psychiatry 2019 34 1 47 53 10.1002/gps.4980 30246408
    [Google Scholar]
  61. Lyu J. Zhang J. Mu H. Li W. Champ M. Xiong Q. Gao T. Xie L. Jin W. Yang W. Cui M. Gao M. Li M. The effects of music therapy on cognition, psychiatric symptoms, and activities of daily living in patients with alzheimer’s disease. J. Alzheimers Dis. 2018 64 4 1347 1358 10.3233/JAD‑180183 29991131
    [Google Scholar]
  62. Matziorinis A.M. Koelsch S. The promise of music therapy for Alzheimer’s disease: A review. Ann. N. Y. Acad. Sci. 2022 1516 1 11 17 10.1111/nyas.14864 35851957
    [Google Scholar]
  63. Theleritis C. Siarkos K. Katirtzoglou E. Politis A. Pharmacological and nonpharmacological treatment for apathy in alzheimer disease. J. Geriatr. Psychiatry Neurol. 2017 30 1 26 49 10.1177/0891988716678684 28248559
    [Google Scholar]
  64. Zhu S. Sui Y. Shen Y. Zhu Y. Ali N. Guo C. Wang T. Effects of virtual reality intervention on cognition and motor function in older adults with mild cognitive impairment or dementia: A systematic review and meta-analysis. Front. Aging Neurosci. 2021 13 586999 10.3389/fnagi.2021.586999 34025384
    [Google Scholar]
  65. Robert P. Benoit M. Rachid G. Pierre-David P. Emmanuelle C. Valeria M. Chaurasia G. George D. Is it possible to use highly realistic virtual reality in the elderly? A feasibility study with image-based rendering. Neuropsychiatr. Dis. Treat. 2015 11 557 563 10.2147/NDT.S73179 25834437
    [Google Scholar]
  66. Larson E.B. Feigon M. Gagliardo P. Dvorkin A.Y. Virtual reality and cognitive rehabilitation: A review of current outcome research. NeuroRehabilitation 2014 34 4 759 772 10.3233/NRE‑141078 24820166
    [Google Scholar]
  67. Gatica-Rojas V. Méndez-Rebolledo G. Virtual reality interface devices in the reorganization of neural networks in the brain of patients with neurological diseases. Neural Regen. Res. 2014 9 8 888 896 10.4103/1673‑5374.131612 25206907
    [Google Scholar]
  68. Hamad A. Jia B. How virtual reality technology has changed our lives: An overview of the current and potential applications and limitations. Int. J. Environ. Res. Public Health 2022 19 18 11278 10.3390/ijerph191811278 36141551
    [Google Scholar]
  69. Yiannopoulou K.G. Papageorgiou S.G. Current and future treatments in alzheimer disease: An update. J. Cent. Nerv. Syst. Dis. 2020 12 10.1177/1179573520907397 32165850
    [Google Scholar]
  70. Diersch N. Wolbers T. The potential of virtual reality for spatial navigation research across the adult lifespan. J. Exp. Biol. 2019 222 Pt Suppl 1 jeb187252 10.1242/jeb.187252
    [Google Scholar]
  71. Allain P. Foloppe D.A. Besnard J. Yamaguchi T. Etcharry-Bouyx F. Gall L.D. Nolin P. Richard P. Detecting everyday action deficits in Alzheimer’s disease using a nonimmersive virtual reality kitchen. J. Int. Neuropsychol. Soc. 2014 20 5 468 477 10.1017/S1355617714000344 24785240
    [Google Scholar]
  72. Doniger G.M. Beeri M.S. Bahar-Fuchs A. Gottlieb A. Tkachov A. Kenan H. Livny A. Bahat Y. Sharon H. Ben-Gal O. Cohen M. Zeilig G. Plotnik M. Virtual reality‐based cognitive‐motor training for middle‐aged adults at high Alzheimer’s disease risk: A randomized controlled trial. Alzheimers Dement. 2018 4 1 118 129 10.1016/j.trci.2018.02.005 29955655
    [Google Scholar]
  73. Jonson M. Avramescu S. Chen D. Alam F. The role of virtual reality in screening, diagnosing, and rehabilitating spatial memory deficits. Front. Hum. Neurosci. 2021 15 628818 10.3389/fnhum.2021.628818 33613216
    [Google Scholar]
  74. Liu Y. Tan W. Chen C. Liu C. Yang J. Zhang Y. A review of the application of virtual reality technology in the diagnosis and treatment of cognitive impairment. Front. Aging Neurosci. 2019 11 280 10.3389/fnagi.2019.00280 31680934
    [Google Scholar]
  75. Miller H.L. Bugnariu N.L. Level of immersion in virtual environments impacts the ability to assess and teach social skills in autism spectrum disorder. Cyberpsychol. Behav. Soc. Netw. 2016 19 4 246 256 10.1089/cyber.2014.0682 26919157
    [Google Scholar]
  76. García-Betances R.I. Waldmeyer A.M.T. Fico G. Cabrera-Umpiérrez M.F. A succinct overview of virtual reality technology use in Alzheimer’s disease. Front. Aging Neurosci. 2015 7 80 10.3389/fnagi.2015.00080 26029101
    [Google Scholar]
  77. Baker R. Bell S. Baker E. Holloway J. Pearce R. Dowling Z. Thomas P. Assey J. Wareing L-A. Wareing L.A. A randomized controlled trial of the effects of multi‐sensory stimulation (MSS) for people with dementia. Br. J. Clin. Psychol. 2001 40 1 81 96 10.1348/014466501163508 11317951
    [Google Scholar]
  78. Coyle H. Traynor V. Solowij N. Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: Systematic review of the literature. Am. J. Geriatr. Psychiatry 2015 23 4 335 359 10.1016/j.jagp.2014.04.009 24998488
    [Google Scholar]
  79. Oliveira J. Gamito P. Souto T. Conde R. Ferreira M. Corotnean T. Fernandes A. Silva H. Neto T. Virtual reality-based cognitive stimulation on people with mild to moderate dementia due to alzheimer’s disease: A pilot randomized controlled trial. Int. J. Environ. Res. Public Health 2021 18 10 5290 10.3390/ijerph18105290 34065698
    [Google Scholar]
  80. Verkaik R. Weert V.J.C.M. Francke A.L. The effects of psychosocial methods on depressed, aggressive and apathetic behaviors of people with dementia: A systematic review. Int. J. Geriatr. Psychiatry 2005 20 4 301 314 10.1002/gps.1279 15799081
    [Google Scholar]
  81. Moreno A. Wall K.J. Thangavelu K. Craven L. Ward E. Dissanayaka N.N. A systematic review of the use of virtual reality and its effects on cognition in individuals with neurocognitive disorders. Alzheimers Dement. 2019 5 1 834 850 10.1016/j.trci.2019.09.016 31799368
    [Google Scholar]
  82. Sánchez-Nieto D. Castaño-Castaño S. Navarro-Martos R. Obrero-Gaitán E. Cortés-Pérez I. Nieto-Escamez F. An intervention on anxiety symptoms in moderate alzheimer’s disease through virtual reality: A feasibility study and lessons learned. Int. J. Environ. Res. Public Health 2023 20 3 2727 10.3390/ijerph20032727 36768091
    [Google Scholar]
  83. Kim J. Lee J. Kim Y. Nuseibeh B. Han S. The effects of a nature-based virtual reality program on emotional health and quality of life among older adults with dementia. Am. J. Health Behav. 2023 47 1 3 12 10.5993/AJHB.47.1.1 36945101
    [Google Scholar]
  84. Appel L. Ali S. Narag T. Mozeson K. Pasat Z. Orchanian-Cheff A. Campos J.L. Virtual reality to promote wellbeing in persons with dementia: A scoping review. J. Rehabil. Assist. Technol. Eng. 2021 8 20556683211053952 10.1177/20556683211053952
    [Google Scholar]
  85. Lasaponara S. Marson F. Doricchi F. Cavallo M. A scoping review of cognitive training in neurodegenerative diseases via computerized and virtual reality tools: What we know so far. Brain Sci. 2021 11 5 528 10.3390/brainsci11050528 33919244
    [Google Scholar]
  86. Maggio M.G. Benenati A. Impellizzeri F. Rizzo A. Barbera M. Cannavò A. Gregoli V. Morone G. Chirico F. Quartarone A. Calabrò R.S. Impact of cognitive vr vs. traditional training on emotional self-efficacy and cognitive function in patients with multiple sclerosis: A retrospective study focusing on gender differences. Brain Sci. 2024 14 12 1227 10.3390/brainsci14121227 39766426
    [Google Scholar]
  87. Marotta N. Calafiore D. Curci C. Lippi L. Ammendolia V. Ferraro F. Invernizzi M. SIRE D.A. Integrating virtual reality and exergaming in cognitive rehabilitation of patients with Parkinson disease: A systematic review of randomized controlled trials. Eur. J. Phys. Rehabil. Med. 2023 58 6 818 826 10.23736/S1973‑9087.22.07643‑2 36169933
    [Google Scholar]
  88. Sofaer N. Strech D. The need for systematic reviews of reasons. Bioethics 2012 26 6 315 328 10.1111/j.1467‑8519.2011.01858.x 21521251
    [Google Scholar]
  89. Buele J. Varela-Aldás J.L. Palacios-Navarro G. Virtual reality applications based on instrumental activities of daily living (iADLs) for cognitive intervention in older adults: A systematic review. J. Neuroeng. Rehabil. 2023 20 1 168 10.1186/s12984‑023‑01292‑8 38110970
    [Google Scholar]
  90. Chen X. Liu F. Lin S. Yu L. Lin R. Effects of virtual reality rehabilitation training on cognitive function and activities of daily living of patients with poststroke cognitive impairment: A systematic review and meta-analysis. Arch. Phys. Med. Rehabil. 2022 103 7 1422 1435 10.1016/j.apmr.2022.03.012 35417757
    [Google Scholar]
  91. Clay F. Howett D. FitzGerald J. Fletcher P. Chan D. Price A. Use of immersive virtual reality in the assessment and treatment of alzheimer’s disease: A systematic review. J. Alzheimers Dis. 2020 75 1 23 43 10.3233/JAD‑191218 32280091
    [Google Scholar]
  92. Hao J. Li Y. Swanson R. Chen Z. Siu K.C. Effects of virtual reality on physical, cognitive, and psychological outcomes in cancer rehabilitation: A systematic review and meta-analysis. Support. Care Cancer 2023 31 2 112 10.1007/s00520‑022‑07568‑4 36633695
    [Google Scholar]
  93. Kruse C.S. Sen K. Armenta V. Hubbard N. Brooks R. Leveraging mhealth and virtual reality to improve cognition for alzheimer’s patients: A systematic review. Healthcare 2022 10 10 1845 10.3390/healthcare10101845 36292292
    [Google Scholar]
  94. Son C. Park J.H. Ecological effects of VR-based cognitive training on ADL and IADL in MCI and AD patients: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health 2022 19 23 15875 10.3390/ijerph192315875 36497946
    [Google Scholar]
  95. Yi Y. Hu Y. Cui M. Wang C. Wang J. Effect of virtual reality exercise on interventions for patients with Alzheimer’s disease: A systematic review. Front. Psychiatry 2022 13 1062162 10.3389/fpsyt.2022.1062162 36440413
    [Google Scholar]
  96. Zhu X.C. Yu Y. Wang H.F. Jiang T. Cao L. Wang C. Wang J. Tan C.C. Meng X.F. Tan L. Yu J.T. Physiotherapy intervention in Alzheimer’s disease: Systematic review and meta-analysis. J. Alzheimers Dis. 2015 44 1 163 174 10.3233/JAD‑141377 25201787
    [Google Scholar]
  97. Zhang Q. Fu Y. Lu Y. Zhang Y. Huang Q. Yang Y. Zhang K. Li M. Impact of virtual reality-based therapies on cognition and mental health of stroke patients: Systematic review and meta-analysis. J. Med. Internet Res. 2021 23 11 e31007 10.2196/31007 34787571
    [Google Scholar]
  98. Moher D. Liberati A. Tetzlaff J. Altman D.G. PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009 6 7 e1000097 10.1371/journal.pmed.1000097 19621072
    [Google Scholar]
  99. Hofmann M. Rösler A. Schwarz W. Müller-Spahn F. Kräuchi K. Hock C. Seifritz E. Interactive computer-training as a therapeutic tool in Alzheimer’s disease. Compr. Psychiatry 2003 44 3 213 219 10.1016/S0010‑440X(03)00006‑3 12764709
    [Google Scholar]
  100. Hwang J. Lee S. The effect of virtual reality program on the cognitive function and balance of the people with mild cognitive impairment. J. Phys. Ther. Sci. 2017 29 8 1283 1286 10.1589/jpts.29.1283 28878448
    [Google Scholar]
  101. Kang J.M. Kim N. Lee S.Y. Woo S.K. Park G. Yeon B.K. Park J.W. Youn J.H. Ryu S.H. Lee J.Y. Cho S.J. Effect of cognitive training in fully immersive virtual reality on visuospatial function and frontal-occipital functional connectivity in predementia: Randomized controlled trial. J. Med. Internet Res. 2021 23 5 e24526 10.2196/24526 33955835
    [Google Scholar]
  102. Maeng S. Hong J.P. Kim W.H. Kim H. Cho S.E. Kang J.M. Na K.S. Oh S.H. Park J.W. Bae J.N. Cho S.J. Effects of virtual reality-based cognitive training in the elderly with and without mild cognitive impairment. Psychiatry Investig. 2021 18 7 619 627 10.30773/pi.2020.0446 34265200
    [Google Scholar]
  103. Masoumzadeh S. Moussavi Z. Does practicing with a virtual reality driving simulator improve spatial cognition in older adults? a pilot study. Neurosci. Insights 2020 15 2633105520967930 10.1177/2633105520967930 35174332
    [Google Scholar]
  104. Serino S. Pedroli E. Tuena C. Leo D.G. Stramba-Badiale M. Goulene K. Mariotti N.G. Riva G. A novel virtual reality-based training protocol for the enhancement of the “mental frame syncing” in individuals with alzheimer’s disease: A development-of-concept trial. Front. Aging Neurosci. 2017 9 240 10.3389/fnagi.2017.00240 28798682
    [Google Scholar]
  105. Arns L.L. Cerney M.M. The Relationship Between Age and Incidence of Cybersickness among Immersive Environment Users. Proceedings of the 2005 IEEE Conference 2005 on Virtual Reality (VR’05) 2005, pp. 267-268. 10.1109/VR.2005.80
    [Google Scholar]
  106. Martirosov S. Bureš M. Zítka T. Cyber sickness in low-immersive, semi-immersive, and fully immersive virtual reality. Virtual Real. 2022 26 1 15 32 10.1007/s10055‑021‑00507‑4 34025203
    [Google Scholar]
  107. Scales K. Zimmerman S. Miller S.J. Evidence-based nonpharmacological practices to address behavioral and psychological symptoms of dementia. Gerontologist 2018 58 Suppl. 1 S88 S102 10.1093/geront/gnx167 29361069
    [Google Scholar]
  108. Cano-de-la-Cuerda R. Blázquez-Fernández A. Marcos-Antón S. Sánchez-Herrera-Baeza P. Fernández-González P. Collado-Vázquez S. Jiménez-Antona C. Laguarta-Val S. Economic cost of rehabilitation with robotic and virtual reality systems in people with neurological disorders: A systematic review. J. Clin. Med. 2024 13 6 1531 10.3390/jcm13061531
    [Google Scholar]
/content/journals/car/10.2174/0115672050374807250224044204
Loading
/content/journals/car/10.2174/0115672050374807250224044204
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test