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Volume 21, Issue 8
  • ISSN: 1567-2050
  • E-ISSN: 1875-5828

Abstract

Background

Alzheimer's disease (AD) is marked by cognitive decline, amyloid plaques, neurofibrillary tangles, and cholinergic loss. Due to the limited success of amyloid-targeted therapies, attention has shifted to new non-amyloid targets like phosphodiesterases (PDE). This study investigates the potential of phytomolecules and derivatives, particularly 8-Prenyldaidzein, in AD treatment.

Materials and Methods

Phytocompounds and derivatives were screened for drug-likeness, toxicity, BBB permeability, and ADME profiles. Molecular docking was conducted with PDE5A, BACE-1, and AChE, followed by molecular dynamics (MD) simulations on the best binding complexes.

Results

8-Prenyldaidzein, a derivative of daidzein, demonstrated favorable drug-likeness and ADME properties. It exhibited strong binding to PDE5A, BACE-1, and AChE, with MD simulations confirming stable protein-ligand interactions.

Discussion

The multi-target potential of 8-Prenyldaidzein, particularly through non-amyloid pathways, offers a promising approach to AD therapy. Its inhibition of PDE5A, BACE-1, and AChE could address multiple aspects of AD pathology.

Conclusion

8-Prenyldaidzein shows strong potential as a multi-target inhibitor for AD treatment. findings are promising, further experimental validation is needed to confirm its clinical applicability.

© 2024 Bentham Science Publishers
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2025-03-28

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Exploring the Therapeutic Potential of 8-Prenyldaidzein: A Comprehensive Study of its Multi-Target Efficacy in Alzheimer's Disease
Curr Alzheimer Res 21, 578 (2024); https://doi.org/10.2174/0115672050358848241211080546
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  • Article Type:     Research Article
Keyword(s): AChE; Alzheimer's; BACE1; Flemingia vestita; molecular dynamics simulation; PDE5A

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