Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Computer - Aided Drug Design
  4. Volume 21, Issue 1
  5. Article
Volume 21, Issue 1
  • ISSN: 1573-4099
  • E-ISSN: 1875-6697

Abstract

Background

In recent years, the incidence of rectal prolapse has increased significantly due to the sedentary lifestyle and irregular eating habits of modern life. However, there is a lack of clinical studies on the treatment of rectal prolapse with traditional Chinese medicine (TCM) with a large sample size. Therefore, this study investigated the characteristics of rectal prolapse treatment formulas and then studied the network pharmacology of their core therapeutic drugs, which can help to provide a reference for the treatment and postoperative care of rectal prolapse patients.

Objective

This study aimed to explore the prescription characteristics and the mechanism of action of core drugs in the treatment of rectal prolapse in Chinese medicine through data mining and bioinformatics techniques.

Methods

We collected the diagnosis and treatment information of patients with rectal prolapse from January 2014 to September 2021 in the electronic case database of Nanjing Hospital of TCM, mined the patient information and prescription features using R, screened the active ingredients of the core pairs of drugs and disease drug intersection targets using TCMSP and GnenCard databases, and constructed a Protein-protein interaction (PPI) network using STRING and Cytoscape, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of the intersecting targets were performed using Metascape and R.

Results

We found that prolapse is easy to occur in people over 50 years old, preferably in autumn and winter. Commonly used therapeutic Chinese medicines include and , which are mostly deficiency tonic medicines, warm in nature, and belong to spleen meridian. The core therapeutic medicinal pair was “. There were 190 common targets of and , and 71 intersection targets of the drug pair and prolapse. The main components of the core drugs for the treatment of prolapse may be quercetin, kaempferol, Stigmasterol, , and the core targets may be CASP3, AKT1, HIF1A, . The total number of GO entries for the intersection targets of and diseases was 3495, among which the molecular functions accounted for the largest proportion, mainly Pathways in cancer, IL-18 signaling pathway, . KEGG enriched pathway analysis yielded 168 results, and the major pathways were pathways in cancer, lipid and atherosclerosis, IL-17 signaling pathway, .

Conclusion

This study adopted real-world research methodology and used data mining and bioinformatics technology to mine the medication law of rectal prolapse and its core drug action mechanism from the clinical information of Chinese medicine.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cad/10.2174/0115734099288156240517114206
2024-05-24
2024-11-26

  • From This Site

    /content/journals/cad/10.2174/0115734099288156240517114206
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. BolaR GuoM KarimuddinA LiuG PhangPT CrumpT SutherlandJM An examination of rectal prolapse surgery patients' quality of life and symptoms using patient-reported outcome instruments: A prospective cohort study.Am J Surg.2024S0002-96102400102810.1016/j.amjsurg.2024.02.014
     [Google Scholar]
  2. XiC.H. YeT. CaiY.K. Surgical treatment of rectal prolapse and progress.Shanghai Med.201637184
     [Google Scholar]
  3. AscanelliS. MarcelloD. SolianiG. FeoC.V. De TroiaA. CampagnaroA. CarcoforoP. Intraoperative laparoscopic fixation sutures to prevent neorectal prolapse after transanal total mesorectal excision.Dis. Colon Rectum2024671e3e410.1097/DCR.000000000000273537646648
     [Google Scholar]
  4. ShiH. Analysis of the current prevalence and risk factors of anorectal diseases in pregnant women.Guangzhou Med.20225304125
     [Google Scholar]
  5. CormanM.L. Colorectal Surgery.6th edShanghaiShanghai Science and Technology Press2016
     [Google Scholar]
  6. HuangF.L. Clinical efficacy of invigorating spleen-stomach and replenishing qi soup plus flavour in the treatment of rectal prolapse and its effect on prognosis.Inner Mongolia Chin. Med.202140086264
     [Google Scholar]
  7. FangL. A study on the efficacy of peonies injection in the treatment of rectal prolapse.Elect. J. Integr. Chin. West. Med. Cardiovas. Dis.20175182021
     [Google Scholar]
  8. ZhangY. Treatment of rectal prolapse by moxibustion of Qihai acupoints combined with acupoint submergence in 26 cases.Zhongguo Zhenjiu2021410326810.13703/j.0255‑2930.20200416‑k0002
     [Google Scholar]
  9. ChenX.Y. Therapeutic efficacy of buried needles combined with traditional Chinese medicine patch in the treatment of postoperative defecation difficulties after rectal prolapse.Asia-Pac.Trad. Med.20191512139141
     [Google Scholar]
  10. Chinese Academy of Traditional Chinese MedicineClinical Guidelines for the Treatment of Chinese Proctology.BeijingChina Chinese Medicine Publishing House2019
     [Google Scholar]
  11. XuS.M. BaiL.P. LuJ.G. DongQ.J. CaoB. Study on medication rules of traditional chinese medicine in treating constipation through data mining and network pharmacology.BioMed Res. Int.2022202211510.1155/2022/673385136267846
     [Google Scholar]
  12. ZhaoY. Diagnosis and treatment of rectal prolapse.J. Hunan Uni. Trad. Chin. Med.202232025152
     [Google Scholar]
  13. ZhangJ.Y. Eight-formula prescription.BeijingChina Medical Science and Technology Press20171222
     [Google Scholar]
  14. ZhangJ.Y. Eight-formula prescription.BeijingChina Medical Science and Technology Press201728
     [Google Scholar]
  15. SongX.P. Clinical application of the formulae of Shengtang Tang.Modern Dist. Edu. Chin. Med.20232124146149
     [Google Scholar]
  16. ShiG.X. Study of Buzhong Yiqi Decoction “Yiqi Shengyang” compatibilitymechanism based on metabonomics.Zhongguo Shiyan Fangjixue Zazhi20142001103106
     [Google Scholar]
  17. FanT. Huangdi Neijing Suwen.ZhengzhouHenan Science and Technology Press20171117
     [Google Scholar]
  18. JiaW.Y. Therapeutic mechanism of Xiaochaihugranule on acute liver injury induced by thioacetamide in rats throughNrf2 pathway.Zhongguo Shiyan Fangjixue Zazhi20192585459
     [Google Scholar]
  19. LinL. Characteristics of Chai Hu for regulating Qi and its applications.Acta Chin. Med.2022370815891592
     [Google Scholar]
  20. WuW.X. Research progress on the chemical composition and pharmacological effects of Radix Codonopsis pilosulae.Acta Chin. Med. Pharmacol.2023510311211510.19664/j.cnki.1002‑2392.230068
     [Google Scholar]
  21. DuH. Progress in the study of the pharmacological effects of the active ingredients of Atractylodes macrocephala.Jiangsu J. Trad. Chin. Med.202254057680
     [Google Scholar]
  22. LiS.J. Identification of Chuan Wu and Cao Wu and related research progress.Guangming J. Chin. Med.2020351626082610
     [Google Scholar]
  23. ParkD.J. Quercetin attenuates decrease of thioredoxin expression following focal cerebral ischemia and glutamate-induced neuronal cell damage.Neuroscience20204283849
     [Google Scholar]
  24. WangQ. LiuC. Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide‐induced fetal brain injury.Int. J. Dev. Neurosci.201871117518010.1016/j.ijdevneu.2018.09.00830282008
     [Google Scholar]
  25. WangD.Y. YangD.L. Protective effect of isorhamnetin on H2O2-included oxidative stress injury of intestinal epithelial cells.Shaxi J. Trad. Chin. Medi.20234401711
     [Google Scholar]
  26. JiangY.H. HuYangL. Study on anti-gastric cancer machanism of stigmasterol based on network pharmacology.J. Wuhan Polytech. Uni.202342013844
     [Google Scholar]
  27. KongW.Y. Discussion on the application of Chaihu in Zhang Xichun’s “Zhongzhong Ganshi Lu”.Jiangsu Chin. Med.20235512586110.19844/j.cnki.1672‑397X.2023.12.017
     [Google Scholar]
  28. GuoL.F. The mechanism of Danshen Yin in treating gastric cancer based on network pharmacology and molecular docking technology.Clin. J. Chin. Med.2023202319
     [Google Scholar]
  29. DingT. [Colorectal cancer cells induce the formation of cancer-associated fibroblasts by activating the ERK signaling pathway in fibroblasts].Nan Fang Yi Ke Da Xue Xue Bao 2023436943951
     [Google Scholar]
  30. LiC.L. Study on effects of Polysaccharide from Cordyceps Taishanensis on lipid metabolism and inflammatory response in livers of ob/ob mice by regulating intestinal floras.Chinese J. Trad. Med. Sci. Technol.20233004662665
     [Google Scholar]
  31. ZhouH.M. Research progress and predictive analysis of quality markers of the classic formula, Litre Trap Soup.China Modern Chin. Med.20242024119
     [Google Scholar]
  32. LiuT. A Study on the relativity of serum IL-7, IL-6 and β-EP to Pain after surgery for coloproctological disease.Chin J Coloproctol.202242103840
     [Google Scholar]
  33. ZhouH. Study on the effects of Cuyu decoction on the degree of pain and the changes of serum cytokines in patients with mixed hemorrhoids after operation.Jilin J. Chin. Med.2023430666967310.13463/j.cnki.jlzyy.2023.06.012
     [Google Scholar]
  34. LiY. Effect of Tonifying Zhong Yi Qi Tang with different doses of Astragalus combined with modified large C-loop on postoperative anal swelling after rectal mucosal endoprolapse of Zhong Qi subsidence type.Fujian Chin. Med.202354096467
     [Google Scholar]
  35. QianG.Z. Therapeutic effect of interspersed epiphyllum cake moxibustion combined with pelvic floor rehabilitation therapy instrument on postpartum rectal prolapse.Shenzhen J. Integr. Med.20192913323310.16458/j.cnki.1007‑0893.2019.13.015
     [Google Scholar]
  36. FanH. Zhongjing's thoughts on desire syndrome.Global Chin. Med.2024202415
     [Google Scholar]
  37. HuangX.J. Clinical experience of Ye Ling in the treatment of anorectal diseases with TCM.Chinese Med. Bullet.20201919042627
     [Google Scholar]
  38. ZhangC.M. Rethinking the timing of the three causes of action.Zhongguo Xiandai Zhongyao20234304404410.13424/j.cnki.mtcm.2023.04.008
     [Google Scholar]
  39. WangJ.Q. Mingshi formula for low myopia in children with heart Yang in sufficiency Syndrome: A multicentre, double-blind, randomised placebo-controlled study.J. Chin. Med.2024650658759310.13288/j.11‑2166/r.2024.06.008
     [Google Scholar]
/content/journals/cad/10.2174/0115734099288156240517114206
Loading
Prescription Data Mining and Network Pharmacology Study of 1152 Patients with Rectal Prolapse using Traditional Chinese Medicine
Curr. Computeraided Drug Des. 21, 110 (2025); https://doi.org/10.2174/0115734099288156240517114206
/content/journals/cad/10.2174/0115734099288156240517114206
/content/journals/cad/10.2174/0115734099288156240517114206
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Bupleuri radix-Cimicifugae rhizoma; network pharmacology; pharmacological mechanisms; pharmacological patterns; Rectal prolapse; signaling pathways

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test