Biochips for Detection of DNA Mutations

Li-Jun Bi; Xian-En Zhang; Ya-Feng Zhou; Jiao-Yu Deng

doi:10.2174/157341106777698242

ISSN: 1573-4110
E-ISSN: 1875-6727

Biochips for Detection of DNA Mutations
Authors: Li-Jun Bi¹, Xian-En Zhang², Ya-Feng Zhou³ and Jiao-Yu Deng⁴
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¹ Joint Research Group for Analytical Pathogenic Microbiology, State Key Laboratory of Biomacromolecules and State Key Laboratory of Virology, Institute of Biophysics and Wuhan Institute of Virology, Chinese Academy of Sciences, Beijing 100101, China. ² Joint Research Group for Analytical Pathogenic Microbiology, State Key Laboratory of Biomacromolecules and State Key Laboratory of Virology, Institute of Biophysics and Wuhan Institute of Virology, Chinese Academy of Sciences, Beijing 100101, China. ³ Joint Research Group for Analytical Pathogenic Microbiology, State Key Laboratory of Biomacromolecules and State Key Laboratory of Virology, Institute of Biophysics and Wuhan Institute of Virology, Chinese Academy of Sciences, Beijing 100101, China. ⁴ Joint Research Group for Analytical Pathogenic Microbiology, State Key Laboratory of Biomacromolecules and State Key Laboratory of Virology, Institute of Biophysics and Wuhan Institute of Virology, Chinese Academy of Sciences, Beijing 100101, China.
Source: Current Analytical Chemistry, Volume 2, Issue 3, Jul 2006, p. 323 - 330
DOI: https://doi.org/10.2174/157341106777698242
- Available online: 01 Jul 2006

Abstract

DNA mutation is the major cause of gene evolution. The variation of DNA sequence may result in genetic diseases, genotypes, single nucleotide polymorphism, and drug resistance of pathogens. Using biochip technologies, detection of mutations can be performed in parallel under identical conditions, hereby providing a solution to continuously increasing demands for large-scale genetic analysis. This article reviews the development of the biochips for mutation analysis. Features, limitations and applications of various principles are discussed.

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2006-07-01

2025-04-12

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Article Type: Research Article

Keyword(s): Biochip; Detection; DNA mutations; Drug resistance; Genetic diseases

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Biochips for Detection of DNA Mutations

Abstract

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