Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents) - Volume 7, Issue 1, 2008

To review the treatments currently used to treat mycobacteria (latent tuberculosis, clinical tuberculosis, infections due to mycobacteria), focussing on : Doses administered and duration of treatment Levels reached in different body tissues in relation to the chemical characteristics of the drugs The relation between these data and the microbiological parameters of each microorganism To review the above parameters for the ne Read More

Tuberculosis remains the leading cause of mortality worldwide even in the 21st century. This review summarises all facts concerning a front-line antituberculotic drug isoniazide - metabolism, mechanism of activity and resistance. The antimycobacterial pharmacophore moiety of isoniazide has been introduced in a number of various types of molecules (about 510 derivatives have been found) to improve their activity agains Read More

Oxazolidinones are important synthetic antibacterial agents useful for the treatment of multi antibiotic resistant Gram-positive bacterial infections. Since the launch of Linezolid, the first member of the oxazolidinone antibacterial family, there have been many studies directed towards structural optimization and the development of second generation oxazolidinones. The N-aryl 5-acetamido methyl oxazolidinone is the core struct Read More

Tuberculosis (TB) remains the leading cause of mortality due to a single bacterial pathogen, Mycobacterium tuberculosis. The reemergence of tuberculosis as a potential public health threat, the high susceptibility of human immunodeficiency virus-infected persons to the disease, the proliferation of multi-drug-resistant strains (MDR-TB) and, more recently, of extensively drug resistant isolates (XDR-TB) have created a Read More

Pulmonary tuberculosis is an intracellular infection caused by Mycobacterium tuberculosis. Because its intracellular site is commonly the macrophage of the pulmonary system, and that cell has little killing action of its own, an antibiotic that is to be effective against this organism must be able to penetrate the macrophage and exert its action at the intracellular site where the organism resides. The anti-tubercular drugs Read More