Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents) - Volume 7, Issue 4, 2008

In the search for effective, selective and nontoxic antiviral agents, a variety of nucleoside analogues have been synthesized, with different functionalities in the carbohydrate moiety. Unsaturated nucleoside analogues are recognized as an important class of biologically active compounds and appear to be prominent drugs in the management of several viral infections, including HSV, HIV, HBV, HCV and HCMV infections. Cu Read More

Three hundred and fifty million people worldwide are estimated to be chronically infected with hepatitis B virus. 15%-40% of these subjects will develop cirrhosis, liver failure or hepatocellular carcinoma during their life. Approved drugs for chronic hepatitis B treatment include: standard interferon-alpha 2b, pegylated interferon-alpha 2a, lamivudine, adefovir dipivoxil, and entecavir. Unfortunately, these agents are not eff Read More

The treatment of infectious diseases has been complicated by the rising of new pathogens, the spread of antibiotic- resistant strains and the relative inefficacy of antimicrobial chemotherapy in immunocompromised hosts. This has led to renewed interest in the utilization of antibody-based therapies as anti-infective agents. Antibody-based therapies are effective against a wide variety of pathogens. In recent years the Read More

The Oxazolidinones are a promising novel chemical synthetic class of antibiotics identified in the last two decades and have been subjected to intensive discovery efforts. They possess impressive antibacterial activity against Grampositive pathogens. Oxazolidinones act through a unique mechanism of inhibitory bacterial protein biosynthesis. Linezolid (ZyvoxTM) has been the only drug of oxazolidinone class to reach the m Read More

The aim of this study was to investigate the efficacy different of throat antiseptics on the oropharynx in healthy volunteers. A newly developed standardised test method was established. Using 12 volunteers per product to be tested, the reduction in the total colony count was the primary endpoint, and reduction in viridans Streptococci was the secondary endpoint criterion, for the commercial antiseptics neo-angin® N thr Read More

Tenofovir disoproxil fumarate (tenofovir DF) is the generic name of the chemical compound 9- [R- (2[[bis]]isopropoxycarbonyl) oxy]methoxy]phosphonyl]methoxy]propyl] adenine fumarate (1:1), the prodrug of tenofovir, the first nucleotide analogue reverse transcriptase inhibitor approved in October 2001 by the Food and Drugs Administration in USA and then, in February 2002, by the European Medicines Read More