Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) - Volume 23, Issue 14, 2023

Breast cancer is the most common cancer among women worldwide. It is the main reason why women die from cancer. Early diagnosis due to increased public awareness and better screening helps to tackle the disease through surgical resection and curative therapies. Chemotherapies are frequently used for cancer treatment, but these have severe adverse effects due to a lack of target specificity. Formulation developmen Read More

Background: Non-small cell lung cancer (NSCLC) is a common malignant cancer with high incidence and mortality. In recent decade, despite the progress in the treatment and prevention of NSCLC, its prognosis still remains poor. It is urgently needed to identify new potential mechanism and efficacious drugs for NSCLC patients. Objective: The objective of this study is to explore the potential therapeutic role of diterpenoid tans Read More

Background/Introduction: Prostate cancer ranks as the second leading cause of cancer death. No effective pharmacological agent is available for prostate cancer treatment. Berbamine is an alkaloid extracted from the Chinese herb berberis, which exerts an effect on inhibiting cancer cell proliferation. Objective: This study aimed to explore the mechanism of berbamine in inhibiting prostate cancer. Methods: Prostate cance Read More

Background/Introduction: 4-aryl-4H-chromenes have attracted attention as potential anticancer agents. Objective: In an effort to discover effective compounds, we designed a new series of these chromenes with methoxy substitution at 2, 3, 4, 5, and 6 positions. Methods: The synthesized compounds were tested for anticancer properties against two human cancer cell lines (MCF- 7 and PC3) as well as a normal cell line. Fur Read More

Background: Combretastatin A-4 (CA-4) is a natural product isolated from the bark of the South African bush willow tree Combretum caffrum, which exerts tubulin inhibition, but its clinical application is limited due to poor stability and water solubility. 2-aryl benzimidazoles are excellent pharmacological skeletons with many activities, especially in tumor inhibition, and better pharmacokinetic properties. Several scaffold C Read More

Background: Nanoparticles' precise targeting properties are becoming increasingly important in treating cancer and starting to outweigh cancer therapies. Methods: The in vivo anticancer activity of ethyl acetate iron oxide nanoparticles (NPS EAE) of Acalypha wilkesiana Müll. Mosaica was tested using Ehrlich ascites carcinoma cells (EAC). Results: The value of the median lethal dose LD50 limit was found to be 3000 mg/kg. Read More

Background: Trillium tschonoskii Maxim (TTM) exerts antitumor effects on a variety of tumour cells. However, the antitumor mechanism of Diosgenin glucoside (DG) extracted from TTM is not clear. Objective: This study aimed to investigate the anti-tumour effects of DG-induced osteosarcoma MG-63 cells and their molecular mechanism. Methods: CCK-8 assay, HE staining, and flow cytometry were used to detect Read More

Introduction: A variety of key human physiological processes rely on angiogenesis, ranging from reproduction and fetal growth to wound healing and tissue repair. Furthermore, this process significantly contributes to tumor progression, invasion, and metastasis. As the strongest inducer of angiogenesis, Vascular Endothelial Growth Factor (VEGF) and its receptor (VEGFR) are targets of therapeutic research for blocking patho Read More

Background: The polysaccharide extract of C. sinensis, Isaria felina (IF), has antitumor effects. Selenium (Se) can improve disease prevention and reduce the toxicity of toxic elements, but the effect of Se-enriched IF on hepatoma remains unknown. Objective: To determine the organic transformation of Se and compare the antitumor effects between Se-enriched IF (IF-Se) and IF on xenograft H22 hepatoma-bearing mic Read More

The present application reports a series of novel Arcyriaflavin-A derivatives as PIM kinase inhibitors for the effective treatment of cancer. The application also describes the synthesis of compounds in detail, use, pharmaceutical composition, pharmaceutically acceptable salts, and treatment.