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- Volume 21, Issue 15, 2021
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) - Volume 21, Issue 15, 2021
Volume 21, Issue 15, 2021
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The Relevance of Supplemental Vitamin D in Malignancies
Authors: Delia Nica-Badea and Aurelian UdristioiuBackground: Vitamin D has a widely acknowledged role in regulating the metabolism of calcium and phosphate, both essential to bone remodeling. However, numerous studies in recent decades have emphasized the association between low sun exposure and vitamin D deficiency, and an increased risk of extra-skeletal disorders such as cancer. Objective: This mini-review of literature aims to present an objective overview Read More
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Application of Diffusion Weighted Imaging in Prostate Cancer Bone Metastasis: Detection and Therapy Evaluation
Authors: Xue-Qin Gong, Yun-Yun Tao, Ran Wang, Nian Liu, Xiao-Hua Huang, Jing Zheng, Cui Yang, Lin Yang and Xiao-Ming ZhangBackground: Bone metastasis is one of the most common complications of Prostate Cancer (PCa). The detection of distal bone metastasis at the time of initial PCa diagnosis is valuable for the determination of therapeutic methods and for the prognosis of PCa. Many current therapeutic methods target PCa bone metastasis, but no uniform evaluation standard for therapeutic efficacy has been established; in addition, trad Read More
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Anticancer Potential of Azole Containing Marine Natural Products: Current and Future Perspectives
Authors: Dimpy Rani, Vandana Garg and Rohit DuttBackground: Despite significant advancement in oncology research, cancer still poses one of the leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole containing medicinal agents are known for plethora of medicinal properties, including anticancer potent Read More
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Poly (Lactic-co-Glycolic Acid) & Tocopheryl Polyethylene Glycol Succinate Nanoparticles for the Treatment of Different Brain Cancers
Authors: Akhil Kumar, Sankha Bhattacharya, Vikas Sharma and Charan SinghNanotechnology and material science developments emerge in the manufacturing of various novel modes of drug delivery, which have proven scientifically promising. Polymer nanoparticles have high stability, high specificity, high drug-carrying power, control release, and potential to be used in various pathways. They usually supply hydrophilic and hydrophobic molecules with medicines. In this review, we have discussed t Read More
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Anlotinib Overcomes Multiple Drug Resistant Colorectal Cancer Cells via Inactivating PI3K/AKT Pathway
Authors: Weilan Lan, Jinyan Zhao, Wujin Chen, Haixia Shang, Jun Peng and Jiumao LinBackground: Anlotinib is a multi-target tyrosine kinase inhibitor that has been reported to have activity against colorectal cancer. However, the mechanisms of how anlotinib mediates drug-resistance of colorectal cancer have not been fully described. Particularly the potential mechanisms regarding the inhibition of proliferation and induction of apoptosis remain unknown. Objective: In this study, we intended to study the eff Read More
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Recombinant Human IL-11 Promotes Lung Adenocarcinoma A549 Cell Growth and EMT through Activating STAT3/HIF-1α/EMT Signaling Pathway
Authors: Na Peng, Meijun Lu, Mafei Kang, Xiuli Liu, Bihui Li and Cuimei DongBackground: Interleukin-11 (IL-11) could promote invasion and metastasis of cancer cells, however, its mechanism is unclear. Objective: This study aimed to investigate the effects of recombinant human IL-11 (rhIL-11) on lung cancer cell metastasis and growth. Methods: Human lung cancer cell, A549, was cultured and subcutaneously injected into mice to establish Xenograft tumor models. Tumor models were divided into co Read More
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Lumiflavin Enhances the Effects of Ionising Radiation on Ovarian Cancer Stem-Like Cells by Inhibiting Autophagy
Authors: Meiyuan Wu, Yangsheng Huang, Zhaoxia Song and Ruhui YangBackground: The development of Cancer Stem-like Cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian cancer CSCs. Objective: This study aimed to investigate the synergistic effects of lumiflavin and ionising radiation on Read More
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Molecular Evidence of Compound Kushen Injection Against Lung Cancer: A Network Pharmacology-Based Investigation from Western Medicine to Traditional Medicine
Authors: Sixian Liang, Yin Li, Xiangguo Zhang, Yugan Guo and Suming PanBackground: Compound Kushen Injection (CKI) is used clinically for relieving cancer pain and treating various solid tumors, particularly lung cancer. However, the underlying mechanisms of CKI in lung cancer remain to be further elucidated. Objective: This study aimed to obtain evidence regarding the potential efficacy of the active compounds and therapeutic targets of CKI at a molecular level by using Network Pharmac Read More
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Alpha-Terpineol as Antitumor Candidate in Pre-Clinical Studies
Authors: Helber A. Negreiros, Kariely Gonçalves de Moura, Maria L.L. Barreto do Nascimento, Débora C. do Nascimento Rodrigues, Paulo M.P. Ferreir, Débora C. Braz, Marlene Gomes de Farias, Layde de Sousa Corrêia, Ana R.S. Pereira, Lubna K.B. Santos, Juan C.R. Gonçalves, Anderson N. Mendes, Felipe C. Carneiro da Silva, Ana A.C.M. Cavalcant and Joáo Marcelo de Castro e SousaBackground: Alpha-terpineol is monoterpene alcohol with anti-tumor activity against different tumor cell lines (lung, breast, leukemias and colorectal) through blockage of NF-kB expression, which play an important role in tumor cells growth. Objective: Evaluate the antitumor activity of alpha-terpineol in murine Sarcoma 180 cell line. Methods: For the tests, different cytotoxic and genotoxic assays were used, including Tr Read More
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Evaluation of Oxidative Stress Biomarkers in Brain Metastatic and Non-Metastatic Lung Cancer Patients with Different Cell Types
Authors: Emre Bilgin, Gülüzar Atli, Berna B. Duman and Ali I. OktenBackground: Oxidative stress that leads to an imbalanced prooxidant/antioxidant status can be a critical factor affecting lung cancer etiopathology. The antioxidant system provides primary protection under oxidative stress. Objective: The purpose of the study was to investigate the serum antioxidant system status in brain metastatic and non-metastatic lung cancer patients with different cell types. Methods: In this prospect Read More
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Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole- Based Anticancer Agents as Potent Angiogenesis Inhibitors
Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines through various mechanisms. Objective: The goal of this work was to design and synthesize thiadiazole-based anticancer agents with anti-angiogenic activity. Methods: N-aryl-2-[ Read More
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1,3,4-Thiadiazolo (3,2-) Pyrimidine-6-Carbonitrile Scaffold as PARP1 Inhibitors
Background: 1,3,4-thiadiazolo pyrimidine is a lead molecule that is versatile for a wide variety of biological activities and in continuation of our interest in establishing some novel heterocyclic compounds for antitumor activity. Objective: The objective of the study was to synthesize a series of 5-amino-7-(substituted aldehyde)-2[(naphthalene- 2-yloxy)methyl] -[1,3,4]thiadiazolo-[3,2-α]-pyrimidine-6- carbonitrile derivatives and e Read More
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A Fluoro Derivative of Embelin, as Potent B-RAF Inhibitor in Melanoma
Authors: Arunkumar Babu, Shiny P. Laila and Annette FernandezBackground: Melanoma is one of the most common forms of skin cancer, and B-RAF is a mutated protein found in most melanomas. The important function of B-RAF is normal cell growth and survival. Most of the known B-RAF mutations are V600E mutations. Vemurafenib is the fluorine-based drug currently used for V600E mutations. However, this drug has side effects, therefore, more potent drugs with fewer side effects are r Read More
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An Advanced Computational Evaluation for the Most Biologically Active Enantiomers of Chiral Anti-Cancer Agents
Authors: Mohd Suhail and Imran AliBackground: Cancer is a very dangerous disease whose treatment can be improved by removing the factors that cause side effects if the drugs prescribed for cancer are chiral in nature. Objectives: A computational evaluation for the most biologically active enantiomeric form of chiral drugs attacking the DNA of the cell, was made for the first time, and compared with the experimental work done by others previously. Method Read More
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Hydrophobic and Hydrophilic Film-Forming Gels for the Controlled Delivery of Drugs with Different Levels of Hydrophobicity
Authors: Khanh T. Nguyen, Phuong H.L. Tran, Hai V. Ngo and Thao T.D. TranBackground: This study aimed to evaluate the effects of hydrophobic and hydrophilic Film-Forming Gels (FFGs) on the controlled delivery of drugs with different levels of hydrophobicity. Methods: This evaluation was carried out by employing zein and polyvinylpyrrolidone as hydrophobic and hydrophilic film-forming agents, respectively, in combination with hydroxypropyl methylcellulose functionalized as a hydrogel basement Read More
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Novel Anticancer Dimeric Naphthoquinones from Diospyros lotus having Anti- Tumor, Anti-Inflammatory and Multidrug Resistance Reversal Potential: In Vitro, In Vivo and In Silico Evidence
Background: Cancer being a genetically heterogeneous and complex disease and the available therapies are not very effective, rendering them the predominant cause of mortality across the world. The discovery of new anticancer drugs with higher efficacy and milder side effects is a great challenge for health professionals. Objective: The current study focused on the anticancer potential of two known dimeric napthoquione Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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