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image of Harnessing Therapeutic Potential of Allicin Against Cancer: An Exploratory Review

Abstract

Background

The biological name of garlic is L., a familiar spice with various health benefits. These benefits are mainly attributable to the compound diversity of garlic, which includes saponins, polysaccharides, organic sulfides, and phenolic compounds. Allicin exhibits therapeutic activity such as antibacterial, anticancer, anti-inflammatory, immunomodulatory, anti-diabetic, and cardiovascular protection. This present study explores the anticancer potential of allicin, including cell line studies that examine its effects on various cancer types by analyzing the growth inhibition of cancer cells at different allicin concentrations.

Aim

This study aims to present a concise overview of allicin, update patent statistics, and provide detailed insights into its wide range of therapeutic benefits, with a particular emphasis on its anticancer properties.

Methods

A literature review has been conducted using reliable sources, including ClinicalTrials.gov, ScienceDirect, PubMed, Scopus, and other reputable foundations, to assess the true potential of allicin in cancer therapeutics.

Results

Allicin, a naturally occurring compound in garlic, represents a promising treatment approach for cancer due to its potent anticancer properties. Cell line studies have shown that various concentrations of allicin significantly inhibit cancer cell growth, underscoring its effectiveness against cancer types such as breast, pancreatic, liver, renal, osteosarcoma, gastric, colorectal, and stomach cancers. By effectively targeting cancer cells, allicin stands out as a potential therapeutic agent.

Conclusion

The primary goal of the review is to highlight the anticancer potential of allicin, along with an overview of clinical and patent studies.

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2025-01-23
2025-03-26

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References

  1. Saharan R. Pal P. Sachdeva S. Kumar S. Singh R. Garlic the wonder adjuvant in medicinal field. Serb. J. Exp. Clin. Res. 2023 24 159 168
    [Google Scholar]
  2. Santhosha S.G. Jamuna P. Prabhavathi S.N. Bioactive components of garlic and their physiological role in health maintenance: A review. Food Biosci. 2013 3 59 74 10.1016/j.fbio.2013.07.001
    [Google Scholar]
  3. Reyes B.A.S. Dufourt E.C. Ross J. Warner M.J. Tanquilut N.C. Leung A.B. Selected phyto and marine bioactive compounds: alternatives for the treatment of type 2 diabetes. Stud. Nat. Prod. Chem. 2018 55 111 143 10.1016/B978‑0‑444‑64068‑0.00004‑8
    [Google Scholar]
  4. Salehi B. Zucca P. Orhan I.E. Azzini E. Adetunji C.O. Mohammed S.A. Banerjee S.K. Sharopov F. Rigano D. Sharifi-Rad J. Armstrong L. Martorell M. Sureda A. Martins N. Selamoğlu Z. Ahmad Z. Allicin and health: A comprehensive review. Trends Food Sci. Technol. 2019 86 502 516 10.1016/j.tifs.2019.03.003
    [Google Scholar]
  5. Qiu Z.E. Xu J.B. Chen L. Huang Z.X. Lei T.L. Huang Z.Y. Hou X.C. Yang H.L. Lin Q.H. Zhu Y.X. Zhao L. Zhou W.L. Zhang Y.L. Allicin facilitates airway surface liquid hydration by activation of CFTR. Front. Pharmacol. 2022 13 890284 10.3389/fphar.2022.890284 35784719
    [Google Scholar]
  6. Ding L. Wu J. Tang N. Tao L. Xu W. Lu Z. Zhang Y. Antifungal activity of an allicin derivative against penicillium expansum via induction of oxidative stress. J. Basic Microbiol. 2020 60 11-12 962 970 10.1002/jobm.202000267 33022788
    [Google Scholar]
  7. Bose S. Laha B. Banerjee S. Quantification of allicin by high performance liquid chromatography-ultraviolet analysis with effect of post-ultrasonic sound and microwave radiation on fresh garlic cloves. Pharmacogn. Mag. 2014 10 38 Suppl. 2 288 10.4103/0973‑1296.133279 24991105
    [Google Scholar]
  8. Diretto G. Rubio-Moraga A. Argandoña J. Castillo P. Gómez-Gómez L. Ahrazem O. Tissue-specific accumulation of sulfur compounds and saponins in different parts of garlic cloves from purple and white ecotypes. Molecules 2017 22 8 1359 10.3390/molecules22081359 28825644
    [Google Scholar]
  9. Szychowski K. Rybczyńska-Tkaczyk K. Gaweł-Bęben K. Świeca M. Karaś M. Jakubczyk A. Matysiak M. Binduga U. Gmiński J. Characterization of active compounds of different garlic (allium sativum l.) cultivars. Pol. J. Food Nutr. Sci. 2018 68 1 73 81 10.1515/pjfns‑2017‑0005
    [Google Scholar]
  10. Bindu J. Narendhirakannan R.T. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019 9 1 4 10.1007/s13205‑018‑1528‑0
    [Google Scholar]
  11. Borlinghaus J. Albrecht F. Gruhlke M. Nwachukwu I. Slusarenko A. Allicin: Chemistry and biological properties. Molecules 2014 19 8 12591 12618 10.3390/molecules190812591 25153873
    [Google Scholar]
  12. Huang H. Zheng F. Dong X. Wu F. Wu T. Li H. Allicin inhibits tubular epithelial-myofibroblast transdifferentiation under high glucose conditions in vitro. Exp. Ther. Med. 2017 13 1 254 262 10.3892/etm.2016.3913 28123498
    [Google Scholar]
  13. Gruhlke M. Nicco C. Batteux F. Slusarenko A. The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants 2016 6 1 1 10.3390/antiox6010001 28035949
    [Google Scholar]
  14. Bhaumik I. Pal K. Debnath U. Karmakar P. Jana K. Misra A.K. Natural product inspired allicin analogs as novel anti-cancer agents. Bioorg. Chem. 2019 86 259 272 10.1016/j.bioorg.2019.01.057 30731359
    [Google Scholar]
  15. Batiha G.E.S. Beshbishy A.A. Tayebwa D.S. Shaheen M.H. Yokoyama N. Igarashi I. Inhibitory effects of uncaria tomentosa bark, myrtus communis roots, origanum vulgare leaves and cuminum cyminum seeds extracts against the growth of babesia and theileria in vitro. Jpn. J. Vet. Parasitol. 2018 17 1 13
    [Google Scholar]
  16. Sobolewska D. Podolak I. Makowska-Wąs J. Allium ursinum: Botanical, phytochemical and pharmacological overview. Phytochem. Rev. 2015 14 1 81 97 10.1007/s11101‑013‑9334‑0 25774103
    [Google Scholar]
  17. Li L. Song Q. Zhang X. Yan Y. Wang X. Allicin alleviates diabetes mellitus by inhibiting the formation of advanced glycation end products. Molecules 2022 27 24 8793 10.3390/molecules27248793 36557926
    [Google Scholar]
  18. Arellano-Buendía A.S. Castañeda-Lara L.G. Loredo-Mendoza M.L. García-Arroyo F.E. Rojas-Morales P. Argüello-García R. Juárez-Rojas J.G. Tapia E. Pedraza-Chaverri J. Sánchez-Lozada L.G. Osorio-Alonso H. Effects of allicin on pathophysiological mechanisms during the progression of nephropathy associated to diabetes. Antioxidants 2020 9 11 1134 10.3390/antiox9111134 33203103
    [Google Scholar]
  19. Boonpeng S. Siripongvutikorn S. Sae-Wong C. Sutthirak P. The antioxidant and anti- cadmium toxicity properties of garlic extracts. Food Sci. Nutri. 2014 2 6 792 801 10.1002/fsn3.164 25493198
    [Google Scholar]
  20. Hayat S. Cheng Z. Ahmad H. Ali M. Chen X. Wang M. Garlic, from remedy to stimulant: Evaluation of antifungal potential reveals diversity in phytoalexin allicin content among garlic cultivars; allicin containing aqueous garlic extracts trigger antioxidants in cucumber. Front. Plant Sci. 2016 7 1235 10.3389/fpls.2016.01235 27610111
    [Google Scholar]
  21. Percival S.S. Aged garlic extract modifies human immunity. J. Nutr. 2016 146 2 433S 436S 10.3945/jn.115.210427 26764332
    [Google Scholar]
  22. Lee H.S. Lim W.C. Lee S.J. Lee S.H. Lee J.H. Cho H.Y. Antiobesity effect of garlic extract fermented by lactobacillus plantarum bl2 in diet-induced obese mice. J. Med. Food 2016 19 9 823 829 10.1089/jmf.2016.3674 27627701
    [Google Scholar]
  23. Seckiner I. Bayrak O. Can M. Mungan A.G. Mungan N.A. Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats. Int. Braz. J. Urol. 2014 40 4 562 567 10.1590/S1677‑5538.IBJU.2014.04.17 25251961
    [Google Scholar]
  24. Yun H.M. Ban J.O. Park K.R. Lee C.K. Jeong H.S. Han S.B. Hong J.T. Potential therapeutic effects of functionally active compounds isolated from garlic. Pharmacol. Ther. 2014 142 2 183 195 10.1016/j.pharmthera.2013.12.005 24333688
    [Google Scholar]
  25. Shang A. Cao S.Y. Xu X.Y. Gan R.Y. Tang G.Y. Corke H. Mavumengwana V. Li H.B. Bioactive compounds and biological functions of garlic (allium sativum l.). Foods 2019 8 7 246 10.3390/foods8070246 31284512
    [Google Scholar]
  26. Reynaldi R.A. Riza H. Luliana S. Docking study of allicin with sulfonylurea receptor 1, complex 1 and pparγ receptor on insulin resistance. Interaction 2018 7 14
    [Google Scholar]
  27. Poole L.B. The basics of thiols and cysteines in redox biology and chemistry. Free Radic. Biol. Med. 2015 80 148 157 10.1016/j.freeradbiomed.2014.11.013
    [Google Scholar]
  28. Ba L. Gao J. Chen Y. Qi H. Dong C. Pan H. Zhang Q. Shi P. Song C. Guan X. Cao Y. Sun H. Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of pi3k/akt/mtor and mapk/erk/mtor signaling pathways. Phytomedicine 2019 58 152765 10.1016/j.phymed.2018.11.025 31005720
    [Google Scholar]
  29. Zhou Y. Li X. Luo W. Zhu J. Zhao J. Wang M. Sang L. Chang B. Wang B. Allicin in digestive system cancer: From biological effects to clinical treatment. Front. Pharmacol. 2022 13 903259 10.3389/fphar.2022.903259 35770084
    [Google Scholar]
  30. Yang D. Lv Z. Zhang H. Liu B. Jiang H. Tan X. Lu J. Baiyun R. Zhang Z. Activation of the NRF2 signaling pathway involving klf9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats. Biol. Trace Elem. Res. 2017 176 1 192 200 10.1007/s12011‑016‑0821‑1 27561292
    [Google Scholar]
  31. Sarvizadeh M. Hasanpour O. Naderi Ghale-Noie Z. Mollazadeh S. Rezaei M. Pourghadamyari H. Masoud Khooy M. Aschner M. Khan H. Rezaei N. Shojaie L. Mirzaei H. Allicin and digestive system cancers: From chemical structure to its therapeutic opportunities. Front. Oncol. 2021 11 650256 10.3389/fonc.2021.650256 33987085
    [Google Scholar]
  32. Lawson L.D. Hunsaker S.M. Allicin bioavailability and bioequivalence from garlic supplements and garlic foods. Nutrients 2018 10 7 812 10.3390/nu10070812 29937536
    [Google Scholar]
  33. Strehlow B. Bakowsky U. Pinnapireddy S. Kusterer J. Mielke G. Keusgen M. A novel microparticulate formulation with allicin in situ synthesis. J. Pharm. Drug Deliv. Res. 2016 5 1 1 10.4172/2325‑9604.1000143
    [Google Scholar]
  34. Chhabria S.V. Akbarsha M.A. Li A.P. Kharkar P.S. Desai K.B. In situ allicin generation using targeted alliinase delivery for inhibition of MIA PACA-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression. Apoptosis 2015 20 10 1388 1409 10.1007/s10495‑015‑1159‑4 26286853
    [Google Scholar]
  35. Soumya R.S. Sherin S. Raghu K.G. Abraham A. Allicin functionalized locust bean gum nanoparticles for improved therapeutic efficacy: An in silico, in vitro and in vivo approach. Int. J. Biol. Macromol. 2018 109 740 747 10.1016/j.ijbiomac.2017.11.065 29155156
    [Google Scholar]
  36. Yoshimoto N. Saito K. S-alk(en)ylcysteine sulfoxides in the genus allium: Proposed biosynthesis, chemical conversion, and bioactivities. J. Exp. Bot. 2019 70 16 4123 4137 10.1093/jxb/erz243 31106832
    [Google Scholar]
  37. Thayumanavan P. Loganathan C. Iruthayaraj A. Poomani K. Nallaiyan S. S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency. Environ. Toxicol. Pharmacol. 2018 58 21 28 10.1016/j.etap.2017.12.006 29278860
    [Google Scholar]
  38. Nadeem M.S. Kazmi I. Ullah I. Muhammad K. Anwar F. Allicin, an antioxidant and neuroprotective agent, ameliorates cognitive impairment. Antioxidants 2021 11 1 87 10.3390/antiox11010087 35052591
    [Google Scholar]
  39. Zaini A.S. Putra N.R. Idham Z. Md Norodin N.S. Mohd Rasidek N.A. Che Yunus M.A. Mini review: Extraction of allicin from allium sativum using subcritical water extraction. IOP Conf. Series Mater. Sci. Eng. 2020 932 1 012023 10.1088/1757‑899X/932/1/012023
    [Google Scholar]
  40. Mathialagan R. Mansor N. Shamsuddin M.R. Uemura Y. Majeed Z. Optimisation of ultrasonic-assisted extraction (uae) of allicin from garlic (allium sativum l.). Chem. Eng. Trans. 2017 56 1747 1752
    [Google Scholar]
  41. Dhwani S. Pushparaj P. Gurumoorthi P. A review on different extraction and quantification methods of allicin from garlic. J. Xidian Univ 2021 15 183 196
    [Google Scholar]
  42. Li F. Li Q. Wu S. Tan Z. Salting-out extraction of allicin from garlic (allium sativum l.) based on ethanol/ammonium sulfate in laboratory and pilot scale. Food Chem. 2017 217 91 97 10.1016/j.foodchem.2016.08.092 27664612
    [Google Scholar]
  43. Williams D.M. Pant C.M. Process for the production of allicin. US7179632B2, 2007
  44. Biao J. Chen Z. Jinhua L. Siyuan C. Synthesis method for allicin derivative. CN103058903A, 2014
  45. Qingzhang W. Jie L. Lei Y.S. Preparation method for efficiently extracting allicin. CN103571627A, 2014
  46. Heng M.C.Y. Method for enhancing penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeability as carrier molecules. US20110301099A1, 2011
  47. Yu L. Method for producing high quality garlic powder. CN101194703B, 2011
  48. Jian C. Xinxia L. Junmin C. Xiaoming W. Process for extracting alliin from fresh garlic. CN1203057C, 2005
  49. Mirelman D. Wilchek M. Miron T. Rabinkov A. Sivaraman H. Garlic alliinase covalently bound to carrier for continuous production of allician. US6689588B1, 2004
  50. Aye R.D.D. Mueller B. Thienel C. Garlic extracts contg. alliinase - have improved therapeutic activity for treating hypertension, arteriosclerosis, diarrhoea, intestinal worms etc. DE4012884A1, 1991
  51. Bennett N. Ramsey E.D. Improvements in or relating to allium extracts. WO2014009759A2, 2014
  52. Arand A. Arand J.K. Garlic composition for foliar applications. US6511674B1, 2003
  53. Ruitian X. Method for processing, storing and transporting garlic. CN1720825A, 2007
  54. Mansor N. Herng H.J. Samsudin S.J. Sufian S. Uemura Y. Quantification and characterization of allicin in garlic extract. J. Med. Bioeng. 2016 5 1 24 27 10.12720/jomb.5.1.24‑27
    [Google Scholar]
  55. Sung H. Ferlay J. Siegel R.L. Laversanne M. Soerjomataram I. Jemal A. Bray F. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2021 71 3 209 249 10.3322/caac.21660 33538338
    [Google Scholar]
  56. Bray F. Ferlay J. Soerjomataram I. Siegel R.L. Torre L.A. Jemal A. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018 68 6 394 424 10.3322/caac.21492 30207593
    [Google Scholar]
  57. Smyth E.C. Lagergren J. Fitzgerald R.C. Lordick F. Shah M.A. Lagergren P. Cunningham D. Oesophageal cancer. Nat. Rev. Dis. Primers 2017 3 1 17048 10.1038/nrdp.2017.48 28748917
    [Google Scholar]
  58. Villanueva A. Hepatocellular carcinoma. N. Engl. J. Med. 2019 380 15 1450 1462 10.1056/NEJMra1713263 30970190
    [Google Scholar]
  59. Avgerinos K.I. Spyrou N. Mantzoros C.S. Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism 2019 92 121 135 10.1016/j.metabol.2018.11.001 30445141
    [Google Scholar]
  60. Paredes F. Williams H.C. San Martin A. Metabolic adaptation in hypoxia and cancer. Cancer Lett. 2021 502 133 142 10.1016/j.canlet.2020.12.020 33444690
    [Google Scholar]
  61. Kim H. Keum N. Giovannucci E.L. Fuchs C.S. Bao Y. Garlic intake and gastric cancer risk: Results from two large prospective us cohort studies. Int. J. Cancer 2018 143 5 1047 1053 10.1002/ijc.31396 29569711
    [Google Scholar]
  62. Zhou X. Qian H. Zhang D. Zeng L. Garlic intake and the risk of colorectal cancer. Medicine 2020 99 1 e18575 10.1097/MD.0000000000018575 31895803
    [Google Scholar]
  63. Zhang Q. Yang D. Allicin suppresses the migration and invasion in cervical cancer cells mainly by inhibiting NRF2. Exp. Ther. Med. 2019 17 3 1523 1528 30783417
    [Google Scholar]
  64. Müller A. Eller J. Albrecht F. Prochnow P. Kuhlmann K. Bandow J.E. Slusarenko A.J. Leichert L.I.O. Allicin induces thiol stress in bacteria through s-allylmercapto modification of protein cysteines. J. Biol. Chem. 2016 291 22 11477 11490 10.1074/jbc.M115.702308 27008862
    [Google Scholar]
  65. Tu G. Zhang Y.F. Wei W. Li L. Zhang Y. Yang J. Xing Y. Allicin attenuates h2o2-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species. Mol. Med. Rep. 2016 13 3 2320 2326 10.3892/mmr.2016.4797 26781848
    [Google Scholar]
  66. Catanzaro E. Canistro D. Pellicioni V. Vivarelli F. Fimognari C. Anticancer potential of allicin: A review. Pharmacol. Res. 2022 177 106118 10.1016/j.phrs.2022.106118 35134476
    [Google Scholar]
  67. Seeneevassen L. Bessède E. Mégraud F. Lehours P. Dubus P. Varon C. Gastric cancer: Advances in carcinogenesis research and new therapeutic strategies. Int. J. Mol. Sci. 2021 22 7 3418 10.3390/ijms22073418 33810350
    [Google Scholar]
  68. Luo R. Fang D. Hang H. Tang Z. The mechanism in gastric cancer chemoprevention by allicin. Anticancer. Agents Med. Chem. 2016 16 7 802 809 10.2174/1871520616666151111115443 26555611
    [Google Scholar]
  69. Pennathur A. Gibson M.K. Jobe B.A. Luketich J.D. Oesophageal carcinoma. Lancet 2013 381 9864 400 412 10.1016/S0140‑6736(12)60643‑6 23374478
    [Google Scholar]
  70. Gravitz L. Liver cancer. Nature 2014 516 7529 S1 10.1038/516S1a 25470192
    [Google Scholar]
  71. Razumilava N. Gores G.J. Cholangiocarcinoma. Lancet 2014 383 9935 2168 2179 10.1016/S0140‑6736(13)61903‑0 24581682
    [Google Scholar]
  72. Dekker E. Tanis P.J. Vleugels J.L.A. Kasi P.M. Wallace M.B. Colorectal cancer. Lancet 2019 394 10207 1467 1480 10.1016/S0140‑6736(19)32319‑0 31631858
    [Google Scholar]
  73. Mizrahi J.D. Surana R. Valle J.W. Shroff R.T. Pancreatic cancer. Lancet 2020 395 10242 2008 2020 10.1016/S0140‑6736(20)30974‑0 32593337
    [Google Scholar]
  74. Smyth E.C. Nilsson M. Grabsch H.I. van Grieken N.C.T. Lordick F. Gastric cancer. Lancet 2020 396 10251 635 648 10.1016/S0140‑6736(20)31288‑5 32861308
    [Google Scholar]
  75. Rachel Vasanthi A.H. Mansingh D. Dalpati N. Sali V. Alliin the precursor of allicin in garlic extract mitigates proliferation of gastric adenocarcinoma cells by modulating apoptosis. Pharmacogn. Mag. 2018 14 55 84 91 10.4103/pm.pm_342_17
    [Google Scholar]
  76. Zhang X. Zhu Y. Duan W. Feng C. He X. Allicin induces apoptosis of the mgc-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway. Mol. Med. Rep. 2015 11 4 2755 2760 10.3892/mmr.2014.3109 25523417
    [Google Scholar]
  77. Li C. Jing H. Ma G. Liang P. Allicin induces apoptosis through activation of both intrinsic and extrinsic pathways in glioma cells. Mol. Med. Rep. 2018 17 4 5976 5981 10.3892/mmr.2018.8552 29436625
    [Google Scholar]
  78. Peairs K.S. Choi Y. Stewart R.W. Sateia H.F. Screening for breast cancer. Semin. Oncol. 2017 44 1 60 72 10.1053/j.seminoncol.2017.02.004 28395765
    [Google Scholar]
  79. Kim K.H. Cho S.J. Kim B.O. Pyo S. Differential pro-apoptotic effect of allicin in oestrogen receptor-positive or -negative human breast cancer cells. J. Funct. Foods 2016 25 341 353 10.1016/j.jff.2016.06.019
    [Google Scholar]
  80. Mondal A. Banerjee S. Bose S. Mazumder S. Haber R.A. Farzaei M.H. Bishayee A. Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations. Pharmacol. Res. 2022 175 105837 10.1016/j.phrs.2021.105837 34450316
    [Google Scholar]
  81. Rosas-González V.C. Téllez-Bañuelos M.C. Hernández-Flores G. Bravo-Cuellar A. Aguilar-Lemarroy A. Jave-Suárez L.F. Haramati J. Solorzano-Ibarra F. Ortiz-Lazareno P.C. Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple- negative breast cancer: Caspase, ΔΨm, and pro-apoptotic gene involvement. Fundam. Clini. Pharmacol. 2020 34 2020 671 686
    [Google Scholar]
  82. Roseblade A. Ung A. Bebawy M. Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer. Acta Pharmacol. Sin. 2017 38 10 1353 1368 10.1038/aps.2016.170 28858299
    [Google Scholar]
  83. Anwanwan D. Singh S.K. Singh S. Saikam V. Singh R. Challenges in liver cancer and possible treatment approaches. Biochim. Biophys. Acta Rev. Cancer 2020 1873 1 188314 10.1016/j.bbcan.2019.188314 31682895
    [Google Scholar]
  84. Li X. Ramadori P. Pfister D. Seehawer M. Zender L. Heikenwalder M. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat. Rev. Cancer 2021 21 9 541 557 10.1038/s41568‑021‑00383‑9 34326518
    [Google Scholar]
  85. Chu Y.L. Ho C.T. Chung J.G. Rajasekaran R. Sheen L.Y. Allicin induces p53-mediated autophagy in hep g2 human liver cancer cells. J. Agric. Food Chem. 2012 60 34 8363 8371 10.1021/jf301298y 22860996
    [Google Scholar]
  86. Zou X. Liang J. Sun J. Hu X. Lei L. Wu D. Liu L. Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ros-mediated mitochondrial pathway. J. Pharmacol. Sci. 2016 131 4 233 240 10.1016/j.jphs.2016.04.017 27177453
    [Google Scholar]
  87. Li J. Ma X. Chakravarti D. Shalapour S. DePinho R.A. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 2021 35 11-12 787 820 10.1101/gad.348226.120 34074695
    [Google Scholar]
  88. Baidoun F. Elshiwy K. Elkeraie Y. Merjaneh Z. Khoudari G. Sarmini M.T. Gad M. Al-Husseini M. Saad A. Colorectal cancer epidemiology: Recent trends and impact on outcomes. Curr. Drug Targets 2021 22 9 998 1009 10.2174/18735592MTEx9NTk2y 33208072
    [Google Scholar]
  89. Schäfer G. Kaschula C. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anticancer. Agents Med. Chem. 2014 14 2 233 240 10.2174/18715206113136660370 24237225
    [Google Scholar]
  90. Huang W. Wu S. Xu S. Ma Y. Wang R. Jin S. Zhou S. Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of nf‐κb signaling pathway. J. Food Sci. 2020 85 6 1924 1931 10.1111/1750‑3841.15156 32418198
    [Google Scholar]
  91. Tao M. Gao L. Pan J. Wang X. Study on the inhibitory effect of allicin on human gastric cancer cell line sgc-7901 and its mechanism. Afr. J. Tradit. Complement. Altern. Med. 2013 11 1 176 179 10.4314/ajtcam.v11i1.28 24653574
    [Google Scholar]
  92. Chakraborty S. Balan M. Sabarwal A. Choueiri T.K. Pal S. Metabolic reprogramming in renal cancer: Events of a metabolic disease. Biochim. Biophys. Acta Rev. Cancer 2021 1876 1 188559 10.1016/j.bbcan.2021.188559 33965513
    [Google Scholar]
  93. Morris M.R. Latif F. The epigenetic landscape of renal cancer. Nat. Rev. Nephrol. 2017 13 1 47 60 10.1038/nrneph.2016.168 27890923
    [Google Scholar]
  94. Karumanchi S.A. Merchan J. Sukhatme V.P. Renal cancer: Molecular mechanisms and newer therapeutic options. Curr. Opin. Nephrol. Hypertens. 2002 11 1 37 42 10.1097/00041552‑200201000‑00006 11753085
    [Google Scholar]
  95. Song B. Shu Y. Cui T. Fu P. Allicin inhibits human renal clear cell carcinoma progression via suppressing hif pathway. Int. J. Clin. Exp. Med. 2015 8 11 20573 20580 26884975
    [Google Scholar]
  96. Li M. Ning J. Huang H. Jiang S. Zhuo D. Allicin protects against renal ischemia–reperfusion injury by attenuating oxidative stress and apoptosis. Int. Urol. Nephrol. 2022 54 7 1761 1768 10.1007/s11255‑021‑03014‑2 34825305
    [Google Scholar]
  97. Xu N. Han W. Yun G. Shi L. Allicin protects renal function, improves oxidative stress and lipid peroxidation in rats with chronic renal failure. Iran. J. Kidney Dis. 2023 17 3 135 140 37337797
    [Google Scholar]
  98. Chen C. Xie L. Ren T. Huang Y. Xu J. Guo W. Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs. Cancer Lett. 2021 500 1 10 10.1016/j.canlet.2020.12.024 33359211
    [Google Scholar]
  99. Shoaib Z. Fan T.M. Irudayaraj J.M.K. Osteosarcoma mechanobiology and therapeutic targets. Br. J. Pharmacol. 2022 179 2 201 217 10.1111/bph.15713 34679192
    [Google Scholar]
  100. Jafari F. Javdansirat S. Sanaie S. Naseri A. Shamekh A. Rostamzadeh D. Dolati S. Osteosarcoma: A comprehensive review of management and treatment strategies. Ann. Diagn. Pathol. 2020 49 151654 10.1016/j.anndiagpath.2020.151654 33130384
    [Google Scholar]
  101. Jiang W. Huang Y. Wang J.P. Yu X.Y. Zhang L.Y. The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo. Asian Pac. J. Cancer Prev. 2013 14 8 4615 4619 10.7314/APJCP.2013.14.8.4615 24083713
    [Google Scholar]
  102. Li X. Ni J. Tang Y. Wang X. Tang H. Li H. Zhang S. Shen X. Allicin inhibits mouse colorectal tumorigenesis through suppressing the activation of stat3 signaling pathway. Nat. Prod. Res. 2019 33 18 2722 2725 10.1080/14786419.2018.1465425 29683343
    [Google Scholar]
  103. Țigu A.B. Toma V.A. Moț A.C. Jurj A. Moldovan C.S. Fischer-Fodor E. Berindan-Neagoe I. Pârvu M. The synergistic antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells. Molecules 2020 25 8 1947 10.3390/molecules25081947 32331446
    [Google Scholar]
  104. Perez-Ortiz J.M. Galan-Moya E.M. de la Cruz-Morcillo M.A. Rodriguez J.F. Gracia I. Garcia M.T. Redondo-Calvo F.J. Cost effective use of a thiosulfinate-enriched allium sativum extract in combination with chemotherapy in colon cancer. Int. J. Mol. Sci. 2020 21 8 2766 10.3390/ijms21082766 32316312
    [Google Scholar]
  105. Chu Y.L. Ho C.T. Chung J.G. Raghu R. Lo Y.C. Sheen L.Y. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy. J. Agric. Food Chem. 2013 61 41 9839 9848 10.1021/jf403241s 24059278
    [Google Scholar]
  106. Chen H. Zhu B. Zhao L. Liu Y. Zhao F. Feng J. Jin Y. Sun J. Geng R. Wei Y. Allicin inhibits proliferation and invasion in vitro and in vivo via shp-1-mediated stat3 signaling in cholangiocarcinoma. Cell. Physiol. Biochem.: Int. J. Experi. Cell. Physiol. Biochem. Pharmacol. 2018 47 2018 641 653
    [Google Scholar]
  107. Wang C.J. Wang C. Han J. Wang Y.K. Tang L. Shen D.W. Zhao Y. Xu R.H. Zhang H. Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer. Mol. Biol. Rep. 2013 40 12 6579 6585 10.1007/s11033‑013‑2766‑1 24135803
    [Google Scholar]
  108. Hu Y. Chen L. Yi C. Yang F. Chen J. Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma mg-63 cells. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2012 32 4 581 585 10.1007/s11596‑012‑1000‑z 22886974
    [Google Scholar]
  109. Miron T. Rabinkov A. Wilchek M. Mirelman D. Volk T. Use of allicin as insect repellent and insecticide in agricultural crops. WO2003090537A2, 2003
  110. Bennett N.M. Josling P.D. Use of allicin as preservative, as disinfectant, as antimicrobial or as biocidal agent. US20090275667A1, 2009
  111. Jing W. Chengtao W. Yanping C. Baoguo S. Chitosan-immobilized allinase and method for preparing allantolin allicin. CN101696407B, 2011
  112. Yao Y. A natural allicin tablet and preparation method thereof. CA2729617A1, 2018
  113. Devisetty B.N. Shammo B. Linda A. Cinnamaldehyde-Allicin Formulations and Methods of Their Use. US20130059909A1, 2015
  114. Lianda L. Jian C. Yikui L. Wenjun X. Jinyan Z. Xinxia L. Application of allicin injection to prepare medicines treating myocardial infarction disease. CN104490857A, 2018
  115. Jianguo J. Qun L. Jinhua P. Allicin nano liposome and preparation method and application thereof. CN103263408A, 2013
  116. Aibo Tao Allicin multiple enteric piece and preparation method thereof. CN104523637B, 2017
  117. Holzhey M.D.I. Roth H.H.D. Hoepfner V. Use of an "Allicin-Urotropin" product for the area of internal treatment (oral, injections and continuous drip infusions) of humans and animals for fungal diseases. DE4024155C2, 1995
  118. WILDE Food additive comprising bio-active components of garlic. WO2017050314A1, 2017
  119. Rabinkov A. Miron T. Mirelman D. Wilchek M. Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases. US7445802B2, 2008
  120. Youchang M. Xiaomin M. Allicin cyclodextrin clathrate compound, formulation and its preparation method. CN1565430A, 2005
  121. Xingguo Q. Shenyu J. Yanhui Z. Ran D. Botian Method for testing content of garlic oil in composite garlic oil capsule. CN105319314A, 2017
  122. Jiang L. Lunxiang Q. Renhao H. Huilan M. The manufacture method of compound garlic feed additive (reinforced vitamin). CN1031791A, 1989
  123. Mirelman D. Rabinkov A. Galili G. Grafi G. Zhu X.Z. Wilchek M. Recombinant alliinase, its preparation and pharmaceutical compositions comprising it. WO1994008614A1, 1994
  124. Mirelman D. Abramski M. Chet I. Miron T. Rabinkov A. Wilchek M. Method for soil sterilization from pathogens. EP1357791A2, 2003
  125. Pandalis G.D. Heymann E. Use of wild garlic for the treatment or prophylaxis of hyperkeratosis. DE19628284C1, 1997
  126. Kim W. Poisonous insect antidote composition. WO2018008853A1, 2018
  127. Zhinian Z. Qiyue Z. Kuichang Z. Garlic juice beverage and preparation method thereof. CN103284244A, 2014
  128. Shangwen L. Fuhua W. Natural food preservative using bitter gourd as material and its production method. CN1839714A, 2009
  129. Kannar D. Odourless garlic supplement comprising an enteric coating and a deodorizing layer. US7425342B2, 2008
  130. Xingming W. Method for treating phthisis by inhaling atomized purple garlic liquid. CN103933309A, 2014
  131. Kausch A.P. Sellew P. Green garlic and methods of production. US7937889B2, 2011
  132. Hua C. Yongjun Z. Condenser for deep processing of garlic. CN201906481U, 2011
  133. TEJEIDA Method for preparing the benzalkonium chloride and diallyl disulphide oxide complex and use thereof as a biocide. WO2013147576A1, 2013
  134. Jianrong X. Yanbin Z. Garlic oil soft capsules and preparation method thereof. CN103404851A, 2015
  135. Jian C. Qiwu Z. A kind of alliin/alliinase binary release multi-layer tablet. CN101549151A, 2009
  136. Pandalis G. Kiesewetter H. Use of wild garlic for the therapy or prevention of blood circulation disturbances. WO1994005306A1, 1994
  137. Zhenghong Q. Hongyi Z. Preparation method of peeled black garlic. CN103156135A, 2013
  138. Jiang H. Xing Z. Wang Y. Zhang Z. Kumah Mintah B. Dabbour M. Li Y. He R. Huang L. Ma H. Preparation of allicin-whey protein isolate conjugates: Allicin extraction by water, conjugates’ ultrasound-assisted binding and its stability, solubility and emulsibility analysis. Ultrason. Sonochem. 2020 63 104981 10.1016/j.ultsonch.2020.104981 32000052
    [Google Scholar]
  139. Iobbi V. Parisi V. Lanteri A.P. Maggi N. Giacomini M. Drava G. Minuto G. Minuto A. Tommasi N.D. Bisio A. Nmr metabolite profiling for the characterization of vessalico garlic ecotype and bioactivity against xanthomonas campestris pv. campestris. Plants 2024 13 9 1170 10.3390/plants13091170 38732385
    [Google Scholar]
  140. Talib W.H. Baban M.M. Azzam A.O. Issa J.J. Ali A.Y. AlSuwais A.K. Allala S. AL Kury L.T. Allicin and cancer hallmarks. Molecules 2024 29 6 1320 10.3390/molecules29061320 38542956
    [Google Scholar]
  141. Li Y. Ma J. Cao Y. Yang D. Efficient removal of allicin from the stalk of allium fistulosum for dietary fiber production. NPJ Sci. Food 2024 8 1 32 10.1038/s41538‑024‑00275‑w 38877017
    [Google Scholar]
  142. Tang Y. Huang L. Sun X. Ren C. Liu T.W. Wu W. Zhang Z. Zhu W. Effects of allicin on growth performance, antioxidant profile, and microbiota compared to monensin of growing goats. Anim. Sci. J. 2024 95 1 e13917 10.1111/asj.13917 38323750
    [Google Scholar]
  143. Yifan M. Rui X. Yuan L. Feiyun J. Allicin inhibits the biological activities of cervical cancer cells by suppressing circeif4g2. Food Sci. Nutr. 2024 12 4 2523 2536 10.1002/fsn3.3935 38628206
    [Google Scholar]
  144. Sleiman C. Daou R.M. Al Hazzouri A. Hamdan Z. Ghadieh H.E. Harbieh B. Romani M. Garlic and hypertension: Efficacy, mechanism of action, and clinical implications. Nutrients 2024 16 17 2895 10.3390/nu16172895 39275211
    [Google Scholar]
  145. Lu M. Pan J. Hu Y. Ding L. Li Y. Cui X. Zhang M. Zhang Z. Li C. Advances in the study of vascular related protective effect of garlic (allium sativum) extract and compounds. J. Nutr. Biochem. 2024 124 109531 10.1016/j.jnutbio.2023.109531 37984733
    [Google Scholar]
  146. Liu X. Mu T. Sun H. Zhang M. Chen J. Optimisation of aqueous two-phase extraction of anthocyanins from purple sweet potatoes by response surface methodology. Food Chem. 2013 141 3 3034 3041 10.1016/j.foodchem.2013.05.119 23871056
    [Google Scholar]
  147. Krstić M. Teslić N. Bošković P. Obradović D. Zeković Z. Milić A. Pavlić B. Isolation of garlic bioactives by pressurized liquid and subcritical water extraction. Molecules 2023 28 1 369 10.3390/molecules28010369 36615563
    [Google Scholar]
  148. Guo Y. Experimental study on the optimization of extraction process of garlic oil and its antibacterial effects. Afr. J. Tradit. Complement. Altern. Med. 2014 11 2 411 414 10.4314/ajtcam.v11i2.27 25435627
    [Google Scholar]
  149. Shamshad S. Rizvi K.A. Shehnaz H. Jatoi S.A. Shahnaz L. Naqvi S.M.S. Qasim M. Zainab T. Haider A. Novel narc-g1 garlic: Comparative allicin quantification with morpho-biochemical & genetic profiling. Braz. J. Biol. 2024 84 e262697 10.1590/1519‑6984.262697 35976350
    [Google Scholar]
  150. Iberl B. Winkler G. Müller B. Knobloch K. Quantitative determination of allicin and alliin from garlic by hplc*. Planta Med. 1990 56 3 320 326 10.1055/s‑2006‑960969 17221429
    [Google Scholar]
  151. Gîtin L. Dinică R. Neagu C. Dumitrascu L. Sulfur compounds identification and quantification from allium spp. fresh leaves. J. Food Drug Anal. 2014 22 4 425 430 10.1016/j.jfda.2014.04.002 28911456
    [Google Scholar]
  152. Li G.X. Chen L. Hsiao Y. Mannan R. Zhang Y. Luo J. Petralia F. Cho H. Hosseini N. Leprevost F.V. Calinawan A. Li Y. Anand S. Dagar A. Geffen Y. Kumar-Sinha C. Chugh S. Le A. Ponce S. Guo S. Zhang C. Schnaubelt M. Al Deen N.N. Chen F. Caravan W. Houston A. Hopkins A. Newton C.J. Wang X. Polasky D.A. Haynes S. Yu F. Jing X. Chen S. Robles A.I. Mesri M. Thiagarajan M. An E. Getz G.A. Linehan W.M. Hostetter G. Jewell S.D. Chan D.W. Wang P. Omenn G.S. Mehra R. Ricketts C.J. Ding L. Chinnaiyan A.M. Cieslik M.P. Dhanasekaran S.M. Zhang H. Nesvizhskii A.I. Lazar A.J. Paulovich A.G. Antczak A. Green A. Ma’ayan A. Pruetz B. Zhang B. Reva B. Druker B.J. Goldthwaite C.A. Jr Birger C. Mani D.R. Chesla D. Fenyö D. Schadt E.E. Wilson G. Kołodziejczak I. John I. Hafron J. Vo J. Zaalishvili K. Ketchum K.A. Rodland K.D. Nyce K. Wiznerowicz M. Domagalski M.J. Anurag M. Borucki M. Gillette M.A. Birrer M.J. Edwards N.J. Vatanian N. VanderKolk P. McGarvey P.B. Dhir R. Thangudu R.R. Crispen R. Smith R.D. Payne S.H. Cottingham S. Cai S. Carr S.A. Liu T. Le T. Ma W. Zhang X. Lu Y. Shutack Y. Zhang Z. Comprehensive proteogenomic characterization of rare kidney tumors. Cell Rep. Med. 2024 5 5 101547 10.1016/j.xcrm.2024.101547 38703764
    [Google Scholar]
  153. Bala R. Madaan R. Chauhan S. Gupta M. Dubey A.K. Zahoor I. Brijesh H. Calina D. Sharifi-Rad J. Revitalizing allicin for cancer therapy: Advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy. Naunyn Schmiedebergs Arch. Pharmacol. 2024 397 2 703 724 10.1007/s00210‑023‑02675‑3 37615709
    [Google Scholar]
  154. Bhuker S. Kaur A. Rajauria K. Tuli H.S. Saini A.K. Saini R.V. Gupta M. Allicin: A promising modulator of apoptosis and survival signaling in cancer. Med. Oncol. 2024 41 9 210 10.1007/s12032‑024‑02459‑6 39060753
    [Google Scholar]
  155. Shi G. Li X. Wang W. Hou L. Yin L. Wang L. Allicin overcomes doxorubicin resistance of breast cancer cells by targeting the NRF2 pathway. Cell Biochem. Biophys. 2024 82 2 659 667 10.1007/s12013‑024‑01215‑x 38411783
    [Google Scholar]
/content/journals/acamc/10.2174/0118715206343978241223080625
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Harnessing Therapeutic Potential of Allicin Against Cancer: An Exploratory Review
Bentham Science Publishers ; https://doi.org/10.2174/0118715206343978241223080625
/content/journals/acamc/10.2174/0118715206343978241223080625
/content/journals/acamc/10.2174/0118715206343978241223080625
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  • Article Type:     Review Article
Keywords: patent ; extraction ; allicin ; Anticancer ; cell line ; apoptosis

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