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Volume 24, Issue 16
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Introduction

Many bioactive phytochemicals have essential significance for handling various diseases and developing new drugs. The aim was to investigate the anti-tumor activity and the underlying mechanisms of pericarp extract (PPE) and pistachio kernel extract (PKE) alone and combined with cisplatin (CP) in the treatment of prostate cancer.

Methods

The effects of the PPE, PKE, and CP alone and PPE and PKE in combination with CP (PPE+CP and PKE+CP) on the proliferation of PC-3 cells were determined using the MTT assay. The fold changes of , expression against β-actin were determined by real-time technique. Data were analyzed by two-way ANOVA and repeated measure tests.

Results

These research results indicated that a greater anti-proliferative effect of the PPE and PKE was shown in combination with CP compared with treatments using the PPE and PKE or CP alone. The extracts and Cisplatin had good synergistic effects on the inhibition of the proliferation of PC-3 cells. The IC values of PKE+CP were 4.141, 2.140, and 0.884 ug/mL, and PPE+CP were 2.754, 2.061, and 0.753 ug/mL after 24 h, 48 h, and 72 h treatment, respectively. Also, this result presented that the mRNA expression of and increased, and decreased in PC-3 cells.

Conclusions

The finding of this research showed for the first time the anti-carcinogenesis effects of separately and in the combination of PPE, PKE, and CP on the PC-3 prostate cancer cells modulating some genes and that it may be nominated for the herbal anti-cancer medications.

© 2024 Bentham Science Publishers
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2024-10-01
2025-05-09

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/content/journals/acamc/10.2174/0118715206296649240625072637
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Pistacia vera and its Combination with Cisplatin: A Potential Anticancer Candidate by Modulating Apoptotic Genes
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 24, 1233 (2024); https://doi.org/10.2174/0118715206296649240625072637
/content/journals/acamc/10.2174/0118715206296649240625072637
/content/journals/acamc/10.2174/0118715206296649240625072637
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  • Article Type:     Research Article
Keyword(s): Cisplatin; gene expression; phytochemicals; pistacia; prostate anti-cancer; synergistic

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