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Volume 25, Issue 2
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Background

Ultra-short peptides are essential therapeutic agents due to their heightened selectivity and reduced toxicity. Scientific literature documents the utilization of dipeptides, tripeptides, and tetrapeptides as promising agents for combating cancer. We have created a range of tryptophan-based peptides derived from literature sources in order to assess their potential as anticancer drugs.

Methods

We present the results of our study on the antibacterial and anticancer effectiveness of 10 ultra-short peptides that were produced utilizing microwave-assisted solid phase peptide synthesis. The synthesized peptides underwent screening for antibacterial activity using the agar dilution method.

Results

HPLC, LC-MS, 1H NMR, and 13C NMR spectroscopy were used to analyze the synthesized peptides. In tests using the HeLa and MCF-7 cell lines, the synthesized peptides' anticancer efficacy was assessed. The study found that two peptides showed potential median inhibitory concentration (IC) values of 3.9±0.13 µM and 1.8±0.09 µM, respectively, and showed more activity than the reference medication doxorubicin.

Conclusion

The antibacterial activity of synthesized peptides and was found to be better than the other synthetic peptides. MIC value of roughly µg/mL for peptides , , and showed strong antifungal activity against . The synthesized peptides were also evaluated for their anticancer activity against HeLa and MCF-7 cell lines, and found that peptides and were more potent than other peptides against doxorubicin.

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2024-12-26

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/content/journals/acamc/10.2174/0118715206260662240613054521
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Exploring Tryptophan-based Short Peptides: Promising Candidate for Anticancer and Antimicrobial Therapies
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 25, 124 (2025); https://doi.org/10.2174/0118715206260662240613054521
/content/journals/acamc/10.2174/0118715206260662240613054521
/content/journals/acamc/10.2174/0118715206260662240613054521
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  • Article Type:     Research Article
Keyword(s): antibacterial; anticancer activity; antifungal; HeLa; MCF-7; peptides (tripeptides and tetrapeptides); Solid phase peptide synthesis

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